Methionine/Cysteine restriction increases longetivity AND energy expenditure
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@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
Here's a highly interesting study focusing on to what degree selenium supplementation can replace methionine restriction. And the answer is: to a surprisingly large degree, but not completely.
MRs benefits on weight were completely repeated by selenium supplementation. They were almost immune to weight gain on high fat diet.
The mice fed selenium even had a little bit more lean mass, although were also bit longer.
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))))The authors hypothesize that all of this is downstream from IGF-1 reduction. They cite a bunch of studies showing IGF-1 reduction being critical to (some) MR benefits.
And selenium reduces IGF-1 to a similar degree as MR.FGF21 was not the same in both groups. Selenium had almost no effect on it in young male micr. This is why selenium only partially replicates MR. As discussed many times in this thread FGF21 is central to MR's benefits and I think the increase in klotho is downstream from it as well. So that is missing when taking selenium, hence why I don't think selenium supplementation will have as drastic of an effect on longevity as MR.
That was in younger male mice, in older female mice the effect on FGF21 was pretty drastic so there might be sex or age specific effect going on.The authors fed sodium selenite but also checked selenomethionine, which was quite a bit less effective for whatever reason. They checked different dosages so it probably wasn't that.
So if you want to replicate this study using sodium selenite is your best bet.
Unfortunately Brazil nuts contain mostly selenomethionine so that won't be perfect either .Body weight on selenomethionine
@DavidPS this might interest you.
Ever since I posted the above study, I've been wondering why selenomethionine was so much less effective than sodium selenite.
This study might give some answers.
Sodium selenite was able to reverse liver fibrosis in vivo via its metabolite hydrogen selenite, which degrades the excessive collagen in fibrotic tissue.
Sodium selenite yields more hydrogen selenite than selenomethionine. And its pathway towards hydrogen selenite is more straight forward.So maybe the impressive benefits of sodium selenite in terms of replicating MR are due to a metabolite?
Not sure, but worth a mention. And another won for sodium selenite.
The HED in the liver fibrosis study was around 1mg, 3 times per week for 4 weeks.
That's around 430mcg per day, which is pretty high. But I wouldn't be surprised if a lower dose over a longer time had a similar effect. -
@Mauritio what about selenoneine
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@eduardo-crispino Don't know what that is. Maybe if you ask me a more detailed question with some context and even a question mark at then end, I can give you a better answer.
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@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
@eduardo-crispino Don't know what that is. Maybe if you ask me a more detailed question with some context and even a question mark at then end, I can give you a better answer.
Why a question mark?
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@Mauritio weird how you write about health topics and you don't know what that form of selenium is? or weren't triggered to look it up out of interest from me posting it. your post I reply to compares two forms of selenium,, and ive posted a third form.
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@eduardo-crispino First you just through out a random question that you could've easily googled yourself. I would have answered that question if you even put in a tiny amount of effort in it.
Then I'm trying to help you to form better questions and if you would've taken that advice you probably would've gotten a better answer not just by me but when asking other questions in the future.Your reaction: zero accountability and somehow blaming me. Class act.
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@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
@eduardo-crispino First you just through out a random question that you could've easily googled yourself. I would have answered that question if you even put in a tiny amount of effort in it.
Then I'm trying to help you to form better questions and if you would've taken that advice you probably would've gotten a better answer not just by me but when asking other questions in the future.Your reaction: zero accountability and somehow blaming me. Class act.
Everything can be searched on Google or chatgpt and others. So the fact that it's Google searchable doesn't change a thing. There's no need to make any effort, you're talking about forms of selenium and their effect, the question asks what you think of a third form of selenium in this context, everything is clear in the question. A question mark is not necessary to observe that it's an interrogative sentence, and it wouldn't have made any difference, it's pathetic to suggest that adding a question mark would have influenced your answer.
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@Mauritio heh
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Great thread @Mauritio, I read through the whole thread - bravo to you and the others that contributed
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@Mauritio said in Methionine/Cysteine restriction increases longetivity AND energy expenditure:
Another interesting fun fact is that the high carb diet increased the concentration of palmitoleic acid by almost 150%. Its interesting that when the body makes new fat that it is a pro-metabolic MUFA. Palmitoelic acid is contained in macadamia nuts a lot.
"Diabetes induced a decrease of monounsaturated fatty acids and particularly palmitoleic acid in all studied tissues: liver,
aorta, plasma."
https://www.sciencedirect.com/science/article/abs/pii/095528639500026V -
On this website they offer a chart with methionine levels of all kinds of foods.
Apparently people in need of it, can also order methioniase.
Also lots of studies on methionine and cancer .
If someone wants to support real cancer research, thats the way to go.
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio - Thanks for the info and the chart. Here is the chart that I use; it is less precise but it gets the job done.
I revisited Dr. Peat's thoughts on lowering methionine. The approach that I like is to focus on dietary restrictions. Lower sulfur containing amino acids (methionine, cysteine) and higher amounts of gelatin/glycine.
Peatbot.com: To lower methionine intake, you can focus on dietary strategies that reduce the consumption of foods high in methionine. Methionine is an amino acid found in high-protein foods, particularly in muscle meats. Here are some approaches to consider:
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Reduce High-Protein Foods: Limit the intake of foods that are high in methionine, such as muscle meats. Instead, focus on consuming proteins that are lower in methionine.
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Incorporate Gelatin: Gelatin is a protein source that is free of the pro-aging amino acids like methionine. Including gelatin in your diet can help balance the intake of amino acids.
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Balance with Other Protein Sources: Consider consuming proteins from the whole animal, including connective tissues, which provide a more balanced amino acid profile compared to muscle meats alone.
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Increase Plant-Based Proteins: Plant-based proteins generally have lower methionine content compared to animal-based proteins. Incorporating more plant-based foods can help reduce methionine intake.
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Methionine Restriction: Actively restrict methionine intake by being mindful of the protein sources you choose, aiming for those with lower methionine content.
By following these strategies, you can effectively lower methionine intake, which has been associated with increased lifespan in some studies.
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Obesity is a fibroblast growth factor 21 (FGF21)-resistant state
https://pubmed.ncbi.nlm.nih.gov/20682689/
