Vitamin C (IV route) doubles survival time in advanced pancreatic cancer patients
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Linus Pauling is probably smiling while he is looking down upon us from above. High-dose vitamin C as treatment for cancer was one of the most controversial suggestions he was known for, and not only made him many enemies in the medical world, it also partially tarnished his reputation as a Nobel Prize laureate. He is also considered the father of so-called orthomolecular medicine, which is still derided by mainstream medicine as pseudo-scientific and false. Of course, as most of my readers know by now, whatever is labelled “controversial” by mainstream medicine often turns out to be true/right. Despite mocking vitamin C treatment for cancer, without much fanfare certain pharma companies have developed drugs based on vitamin C, with perhaps the most successful to date being the drug Apatone (a combination of vitamin C and vitamin K). Apatone has already been allowed by the FDA to be used on cancer patients including on people with advanced/terminal prostate cancer. So, it is becoming more and more obvious Dr. Linus was right, and just as importantly, the bioenergetic theory of cancer is also right. The study below on pancreatic cancer proposes that vitamin C works by generations hydrogen peroxide (H2O2), which works through the same cytotoxic mechanism as traditional chemotherapy. In other words, medicine reluctantly admits that vitamin C works, but counters any attacks against its approach by claiming that vitamin C is simply another form of cytotoxic chemotherapy. As such, it is used not as a primary treatment, but as an add-on therapy which just increases the potency of traditional chemotherapy. However, if one looks at the published studies on Apatone, a completely different mechanism is proposed – a bioenergetic one. Namely, when vitamin C is combined with an oxidizing agent – vitamin K (as in the drug formulation) or any other quinone-like molecule such as methylene blue, CoQ10, emodin, the tetracycline antibiotics, etc – it gets oxidized to something known as dehydroascorbic acid (DHAA), which itself is a powerful oxidizing agent. Since the vitamin C molecule is structurally very similar to sugar/glucose, it is preferentially uptaken by cancer cells through the same pathways as glucose (e.g. the GLUT proteins), as cancer cells are known to have much higher glucose affinity compared to non-cancer cells. In fact, it is this preferential uptake of glucose by cancer cells that is used both for cancer diagnosis (imaging with radioactive glucose) and has led medicine to keep claiming that cancer is “addicted” to sugar and that carbohydrate restriction, keto diets, fasting, etc should treat cancer. All such approaches have been tried, with disastrous results, as after a brief pause in growth, the cancer becomes highly aggressive and invariably lethal. The bioenergetic theory states that cancer cells uptake more glucose from the blood because they are functionally deficient in glucose. Namely, the glucose that enters cancer cells gets “wasted” by conversion into lactate, due to the cancer cells’ highly reductive state (e.g. low mitochondrial NAD+/NADH ratio) instead of being combusted through OXPHOS. So, the solution would be to provide more glucose, not less. Be that as it may, the Apatone approach is to use a molecule (vitamin C) that uses the same uptake/transport mechanisms as glucose, which results in its preferential accumulation inside cancer cells, and once inside the cancer cell this oxidized form of vitamin C (DHAA) corrects the reductive excess of cancer cells, and after some time they start to respire normally. In other words, Apatone works by converting “cancer” cells back into “normal” cells by gradually changing the redox state of such cells from high reduced to highly oxidized. Why the quotes? Well, it should be clear by now that there is no such thing as a “cancer” cell and a “normal” cells. There is only a continuous spectrum of metabolic health with “cancer” at one end and “health” at the other, with the cell moving back and forth along that spectrum, entirely based on its environmental influences (no mutations needed). However, in order for that process to work the reduced form of vitamin C, which is the one most commonly sold as a supplement, needs to be co-administered with an oxidizing agent (vitamin K, in the case of Apatone) so that DHAA is formed, as DHAA is the true therapeutic agent. Another option is to administer pre-formed DHAA, but that molecule is not very stable and quickly degrades or converts back into the reduced form. Unfortunately, the study below used high amounts of the reduced form of vitamin C (ascorbate) and as such drastically limited its therapeutic potential. While high doses of ascorbate will still raise DHAA formed inside the body, the effects are rather minute compared to administering either preformed DHAA or a combination of vitamin C and a quinone. One can see the vast difference that by comparing the effects of Apatone with the effects seen in the study below. Namely, Apatone as a daily oral dose of just 5g vitamin C (plus 50mg vitamin K) almost completely prevented mortality in patients with end-stage prostate cancer, while a massive 32g daily dose of vitamin C (and by IV route too) merely doubled survival time in patients with pancreatic cancer. Oh well, I guess it is a step in the right direction and it may be just Big Pharma’s nefarious way to slowly switch over to the metabolic treatment of cancer without admitting culpability along the way. Something similar is already happening with the SSRI industry. Now that is becoming painfully obvious that low serotonin is not the cause of depression and, in fact, high serotonin may be the cause, Big Pharma has started to release SSRI drugs that have substantial anti-serotonin effect at the receptor level. So, such drugs may very well work, but Big Pharma gets to publicly save its theory that SSRI drugs are good and so is serotonin, while implementing the exact opposite hypothesis pharmacologically. In 5-10 years, SSRI drugs will quietly get dropped as “obsolete” and nobody will even think of asking the question of why they were even used in the first place, and how many people were harmed/killed by them. It will be a “paradigm shift” as the good ol’ science philosopher Mr. Kuhn said, which is really just a euphemism for “the jig is up, time to find a new one”.
https://dx.doi.org/10.1016/j.redox.2024.103375
https://medicalxpress.com/news/2024-11-high-dose-iv-vitamin-chemotherapy.html
“…Results from a randomized, phase 2 clinical trial show that adding high-dose, intravenous (IV) vitamin C to chemotherapy doubles the overall survival of patients with late-stage metastatic pancreatic cancer from eight months to 16 months….The findings, published in Redox Biology, mark another success for high-dose, intravenous vitamin C, which has overcome many hurdles in the almost 20 years UI researchers have persevered to demonstrate its benefit for cancer patients. “We’ve had ups and downs, of course, but this is a culmination of a lot of people’s hard work,” says Cullen, who is also a member of UI Health Care Holden Comprehensive Cancer Center. “It’s really a positive thing for patients and for the University of Iowa….”Not only does it increase overall survival, but the patients seem to feel better with the treatment,” Cullen says. “They have fewer side effects, and appear to be able to tolerate more treatment, and we’ve seen that in other trials, too.”
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@haidut said in Vitamin C (IV route) doubles survival time in advanced pancreatic cancer patients:
While high doses of ascorbate will still raise DHAA formed inside the body, the effects are rather minute compared to administering either preformed DHAA or a combination of vitamin C and a quinone.
Interesting study. Thank you.
On RPF there is a thread that discusses the making of DHAA, with vitamin C and methylene blue. It's very simple to know when you have the mixture, for the methylene blue goes clear. If using K2 instead, is it just a matter of mixing the K2 with the vitamin C, or should we be looking for a proper reaction, like when the methylene blue goes clear?
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@Mossy in my opinion it's just better to take them separately. dha can irreversibly undergo hydrolysis in plain water and depending on how fast/slow digestion is maybe it starts to break down before it reaches target tissues. I think it makes more sense to let ascorbic acid and methylene blue meet in blood around target tissues and turn into dehyroascorbate and leucomethylene blue there so the dehydroascorbate can be taken up by tissues more immediately.
at most I suggest just mixing them right away and drinking, and not waiting for the solution to turn from blue to clear. -
@sneedful said in Vitamin C (IV route) doubles survival time in advanced pancreatic cancer patients:
@Mossy in my opinion it's just better to take them separately. dha can irreversibly undergo hydrolysis in plain water and depending on how fast/slow digestion is maybe it starts to break down before it reaches target tissues. I think it makes more sense to let ascorbic acid and methylene blue meet in blood around target tissues and turn into dehyroascorbate and leucomethylene blue there so the dehydroascorbate can be taken up by tissues more immediately.
at most I suggest just mixing them right away and drinking, and not waiting for the solution to turn from blue to clear.Thank you. You've answered a question I had asked on RPF, a few years back. I was curious if you could simply take both and let the reaction take place internally. You don't mention K2, but I'll assume the same.
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@Mossy same deal with k2 . I assume you mean mk4. k2 mk4 best absorbs with lots of fat anyways and im not sure eating a bunch of fat with methylene blue seems like an appetizing combination
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@sneedful said in Vitamin C (IV route) doubles survival time in advanced pancreatic cancer patients:
@Mossy same deal with k2 . I assume you mean mk4. k2 mk4 best absorbs with lots of fat anyways and im not sure eating a bunch of fat with methylene blue seems like an appetizing combination
Yes, K2, mk4. Thank you.
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@Mossy oh wait I said methylene blue fat thing that doesn't make sense cause u would be taking k2 mk4 instead. nvm. u get what I mean.
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btw @haidut afaik dhaa works via cancer cell death known as autoschizis. in your article you say dhaa corrects the reductive stress and makes cancer cells respire back to normal. maybe you’re also right too but i feel as if by leaving the cell killing part of it out it is missing part of the story. mayhaps dhaa both kills the deranged cells that are too deranged, and converts others back to normal respiration
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@haidut said in Vitamin C (IV route) doubles survival time in advanced pancreatic cancer patients:
The bioenergetic theory states that cancer cells uptake more glucose from the blood because they are functionally deficient in glucose. Namely, the glucose that enters cancer cells gets “wasted” by conversion into lactate, due to the cancer cells’ highly reductive state (e.g. low mitochondrial NAD+/NADH ratio) instead of being combusted through OXPHOS. So, the solution would be to provide more glucose, not less. Be that as it may, the Apatone approach is to use a molecule (vitamin C) that uses the same uptake/transport mechanisms as glucose, which results in its preferential accumulation inside cancer cells, and once inside the cancer cell this oxidized form of vitamin C (DHAA) corrects the reductive excess of cancer cells, and after some time they start to respire normally. In other words, Apatone works by converting “cancer” cells back into “normal” cells by gradually changing the redox state of such cells from high reduced to highly oxidized.
György, aerobic fermentation is redox neutral:
- Glucose + 2 NAD⁺ → 2 Pyruvate + 2 NADH
- 2 Pyruvate + 2 NADH → 2 Lactate + 2 NAD⁺
Combined:
- Glucose → 2 Lactate
How do you expect more glucose to solve the redox imbalance? It's the metabolic disinhibitions that do the trick, and controlled glucose exposure should be beneficial in the meantime.
Not shown above: about 1 ATP for every pyruvate or lactate formed. It's less than 1 because part of the glycolysis metabolites are diverted and lost.
But alternatively, it's possible to make use of the high flux to induce stress, leading to an overall helpful effect. Glucose must be paired with other compounds. Otherwise, you risk increasing the antioxidative capacity further.
We have the glucose treatment that Ray mentioned, but it was used along with oxygen therapy. Without an adjuvant, in addition to improve the antioxidative capacity, glucose abundance could even reinforce any inhibition of respiration. Straight from Herbie's publication:
Observations on the Carbohydrate Metabolism of Tumours
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@sneedful said in Vitamin C (IV route) doubles survival time in advanced pancreatic cancer patients:
@Mossy oh wait I said methylene blue fat thing that doesn't make sense cause u would be taking k2 mk4 instead. nvm. u get what I mean.
No worries.
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Insulin given in isolation may actually increase the competition for glucose and divert some of it away from cancer cells. If released in response to glucose, whether we get lipolysis under control or not, we would still have the issue of ongoing fermentation and the need for something to change the cell behavior:
Another factor to consider:
Inside the hypoxic tumour: reprogramming of the DDR and radioresistance
Additional information:
Defining normoxia, physoxia and hypoxia in tumours—implications for treatment response
"Despite the many studies on tumour hypoxia, there is considerable confusion in the use of the terms “normoxia” and “hypoxia”. Oxygenation measurements in normal tissues show that they exhibit distinct normal ranges, which vary between tissues (Table 1)."
"However, “normoxia” is almost universally used to describe the “normal” oxygen levels in tissue culture flasks, i.e. about 20–21% oxygen (160 mmHg). Although this is not exact, as it is dependent on altitude and added CO2, for most situations, 20% is a good approximation. Despite the widespread usage of “normoxia”, this is far from an accurate comparator for peripheral tissue oxygenation. Even in lung alveoli, the oxygen level is reduced to about 14.5% oxygen (110 mmHg) by the presence of water vapour and expired CO2.[13] It drops further in arterial blood and, by the time it reaches peripheral tissues, the median oxygen levels range from 3.4% to 6.8% with an average of about 6.1% (Table 2).[13]"
"In defining “pathological hypoxia”, there are no absolutes; however, the reality is that all tumours tend to have median tumour oxygen levels <2% and, within that estimation, individual measurements can vary from about 6% (very rarely) down to zero with a significantly marked skewing towards the lower end of this range; frequently, most values are well below 1.3% oxygen (10 mmHg), especially in the more hypoxic tumours."
Cells can maintain a surprisingly high rate of oxygen consumption in hypoxia:
Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival
- Potassium cyanide (KCN) inhibits Complex IV (where most oxygen is supposed to be metabolized).
"[..]mitochondrial respiration can function at oxygen levels as low as 0.5% (Chandel et al., 1996; Rumsey et al., 1990)." (Luengo, 2021)
Despite the respiratory resistance, some cancer cells are found in severe hypoxia. You want them to respire normally with more glucose, but how, if little oxygen is available? They conserve oxygen by adopting an economical program. If these cancer cells keep up with the glucose flux and metabolize it liberally, it quickly depletes their oxygen and leads to further disturbances.
We can't turn our zealotry to fructose either:
Fructose contributes to the Warburg effect for cancer growth
↳ Direct Spectrophotometric Determination of Serum Fructose in Pancreatic Cancer Patients
↳ Fructose induces transketolase flux to promote pancreatic cancer growth
"The enzyme TKT requires thiamine-derived mitochondrial NAD+ as a cofactor, and NAD synthesis can be disrupted with the thiamine analogue oxythiamine."
I forgot to list DHEA in Locketol:
Of interest, Heinz reported the following:
The Metabolism of Carcinoma Cells
"The carcinoma splits not only glucose to lactic acid, but also mannose, fructose and galactose, the velocity of the glycolysis being:
Toxin Relative speed Galactose 1 Fructose 2.5 Mannose 17 Glucose 18 Glucose is obviously attacked most rapidly and we might add the alpha-form of glucose as rapidly as the beta-form."
In comparison to abundance, glucose limitation is more supportive to increasing reliance on respiration and oxidative phosphorylation, because these are ways to maximize the efficiency in consuming a nutrient that can be depleted. Galactose is not metabolized fast enough to replace the mitochondrial yield. It's used in experiments when researchers want to make cells dependent on the mitochondrial metabolism.
Tumors can have regions with low levels of glucose, but pounding glucose in a state of metabolic derangement and hypoxia is more likely to intensify fermentation, and the typical structural abnormalities must follow.
These are not nutrient contraindications, more like anti-glorifications.
