Anabolic Sensitivity in Healthy, Lean, Older Men

DavidPS

Lean and healthy old men (~age 70) do not show anabolic resistance to resistance exercise and amino acids.

More evidence that much of aging is actually just letting yourself go and becoming overfat and insulin resistant.

Staying lean and fit fights aging

Anabolic Sensitivity in Healthy, Lean, Older Men Is Associated With Higher Expression of Amino Acid Sensors and mTORC1 Activators Compared to Young (2024)

LucH

@DavidPS said in Anabolic Sensitivity in Healthy, Lean, Older Men:

Staying lean and fit fights aging

Hi,
just to make a up, and contribute ...
Nothing to do with insulin insensitivity but as overfat, insulin insensitivity and inflammation are members of the same trilogy, we could add one more point: lack of potassium, preventing adequate cleansing. I explain (context needed):

Oxidized Cholesterol, Macrophages and Potassium
Potassium to dampen high tension and prevent AVC. Atherosclerosis begins with macrophage engulfment of oxidized LDL C-foam cells (process to clean / get rid of Ox-LDL.
=> 2 g K+ more makes a difference (3 g as middle take). So 3 + 2 = 5 000 mg.

Excerpt (translated)
Macrophages are cells that infiltrate tissues and have a cleaning role. They are notably responsible for purifying LDL cholesterol (the wrongly-called “bad” cholesterol). But when this cholesterol is oxidized, macrophages store it in the arterial walls and become the raw material for atherosclerotic plaque. They are then called “foam cells”. By preventing macrophages to adhere to arterial walls, potassium could slow down cardiovascular disease.
Translated from the book “Potassium: Mode d’Emploi”. Dr. Philippe VEROLI.
Chapitre 5 – Prévenir et Traiter les maladies Cardio-Vasculaires.
Sources and References

The role of macrophage ion channels in the progression of atherosclerosis
&3. Ion channels in macrophages
https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2023.1225178/full
Potassium channels are crucial regulators of macrophage membrane potential and ion homeostasis.
Human macrophages contain a stretch-sensitive potassium channel that is activated by adherence and cytokines
https://pubmed.ncbi.nlm.nih.gov/8558596/
We have identified an outwardly rectifying K+ channel that appeared to be involved in cytokine and adherence-mediated macrophage activation, and in the maintenance of cytoskeletal integrity and cell shape.
Inverse relationship between potassium intake and coronary artery disease in the cholesterol-fed rabbit
American Journal of Hypertension, 1999, https://doi.org/10.1016/S0895-7061(99)00039-4
Atherosclerosis begins with macrophage engulfment of oxidized LDL C-foam cells (process to clean / get rid of Ox-LDL.
Researchgate (access denied with VPN)