Random, interesting studies
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"In vitro, 5-HT inhibits rat prostate branching through down-regulation of androgen receptor (AR). "
"...Tph1 knockout mice present higher prostate mass and up-regulation of AR when compared to wild-type,..."
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@Mauritio said in Random, interesting studies:
It seems to come down to age as well.
Here it gets interesting: if you're under 65 and eating a high protein diet, that is strongly associated with death, cancer and diabetes . Over 65 it seems to be protective !"...aged 50–65 reporting high protein intake had a 75% increase in overall mortality and a 4-fold increase in cancer and diabetes mortality..."
https://pmc.ncbi.nlm.nih.gov/articles/PMC3988Another pointer in this direction.
Young mice experienced a 17% decrease in life span when methionine was increased, for old mice it didn't change anything.
So maybe there is an age related effect of protein on the body.
If that's true (and that's still a big if), then im starting to wonder how good Rays low protein phase was shortly before his death, given his advanced age."The lifespan of old mice was unchanged by feeding 0.05M methionine. Young mice, however, experienced a 16.9% decrease in their average lifespan and a decreased maximum lifespan when given supplemental methionine. "
https://www.sciencedirect.com/science/article/abs/pii/0531556584900494I have previously speculated that the mechanism might have to do with the immune system, since a low protein diet can lower thymus weight and that is possibly worse than additional protein in old age .
It could also have to do with heavy metals since amino acids have heavy metal cheating properties and heavy metals tend to accumulate in old age.
https://www.sciencedirect.com/science/article/abs/pii/S2210271X25000076#:~:text=Introduction,4]%2C [5]. -
Thyroid Hormone-Induced Expression of the Hepatic Scaffold Proteins Sestrin2, β-Klotho, and FRS2α in Relation to FGF21-AMPK Signaling
https://pubmed.ncbi.nlm.nih.gov/28895643/ -
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@lobotomize-me said in Random, interesting studies:
Sodium butyrate increases seratonin
: Peripheral (gut) serotonin: In vitro and in vivo studies show that butyrate stimulates tryptophan hydroxylase‑1 (TPH1), the rate‑limiting enzyme for serotonin synthesis in intestinal enterochromaffin cells. Low concentrations of sodium butyrate (0.5–1 mM) increased TPH1 mRNA expression in human EC cells by 2.5–3.5‑fold; high concentrations (>2 mM) suppressed TPH1. A review notes that butyrate in the gut lumen can activate a zinc‑finger transcription factor (ZBP‑89) and stimulate serotonin production in enterochromaffin cells.
Central (brain) serotonin: In mice exposed to chronic unpredictable stress, sodium butyrate treatment alleviated depression‑like behaviours and increased brain serotonin (5‑HT) concentration and brain‑derived neurotrophic factor (BDNF) levels. A gene‑expression study in rats showed that sodium‑butyrate‑induced HDAC inhibition downregulated the 5‑HT₂A receptor in the brain and another study reported up‑regulation of 5‑HT₁A receptor mRNA when sodium butyrate was combined with estrogen therapy (data from behavioural tests) – suggesting receptor‑level modulation rather than direct synthesis of serotonin
SB prevented behavioural deficit made by CUMS
by raising seratonin and BDNF
https://pubmed.ncbi.nlm.nih.gov/26957230/Increase seratonin under stress:
https://pubmed.ncbi.nlm.nih.gov/18817816/https://pmc.ncbi.nlm.nih.gov/articles/PMC4396604/
"When mice were treated with antibiotics to deplete gut microbiota, serotonin levels dropped significantly.
Recolonization of the microbiota or administration of SCFAs restored normal 5-HT levels in the colon"
This means sodium butyrate could be the pathway, gut bacteria use to trigger serotonin production
️https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2022.1035538/full
