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Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?

Literature Review
holy basil tulsi testosterone thyroid
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  • M
    Mauritio
    last edited by Feb 9, 2025, 8:41 PM

    There might be a few MAO-B inhibitors in basil.
    https://pubmed.ncbi.nlm.nih.gov/32883197/

    Dare to think.

    My X:
    x.com/Metabolicmonstr

    1 Reply Last reply Reply Quote 0
    • C
      cs3000
      last edited by cs3000 Feb 10, 2025, 2:30 PM Feb 10, 2025, 1:23 PM

      O. basilicium water extract fully restored glucose & insulin measures in diabetes model
      https://scialert.net/fulltext/?doi=pjbs.2020.1010.1017
      increases glucose uptake by cells
      c89a6be9-7c4b-4678-a198-652feab2748f-image.png

      & increased sleep duration on a sedative more than diazapam , decreased time taken to fall asleep a couple minutes by itself (through GABA) so maybe best timing is PM https://pmc.ncbi.nlm.nih.gov/articles/PMC5020426/#sec162951
      extract with both water & ethanol solubles had greatest effect (potential for gaba rebound though)

      "world," as a source of new perceptions
      more https://substack.com/@cs3001

      "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

      1 Reply Last reply Reply Quote 0
      • M
        Mauritio
        last edited by Mauritio Feb 10, 2025, 9:18 PM Feb 10, 2025, 9:09 PM

        Another reason to favor O. Basilicum !
        Yeah it does have a glucose lowering effect. There's a few studies on basil as a diabetes treatment . I notice the hypoglycemic effect.

        Interesting in that dosage it actually caused sleep issues for me . Although that was O. Sanctum and not O. Basilicum as in this study.

        In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
        https://pubmed.ncbi.nlm.nih.gov/36750371/

        Although in this study it showed no effect on sleep.
        https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        C 1 Reply Last reply Feb 11, 2025, 10:19 AM Reply Quote 0
        • M
          Mauritio
          last edited by Feb 10, 2025, 9:29 PM

          "The biochemical parameters of hepatic function, renal function, glucose, triglyceride, and cholesterol level were significantly reduced in the treatment groups compared with the control group (p < 0.05)"

          https://pubmed.ncbi.nlm.nih.gov/39555564/#&gid=article-figures&pid=figure-1-uid-0

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          1 Reply Last reply Reply Quote 0
          • C
            cs3000 @Mauritio
            last edited by cs3000 Feb 11, 2025, 10:26 AM Feb 11, 2025, 10:19 AM

            @Mauritio
            looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

            In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
            https://pubmed.ncbi.nlm.nih.gov/36750371/
            Although in this study it showed no effect on sleep.
            https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

            so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

            "world," as a source of new perceptions
            more https://substack.com/@cs3001

            "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

            M 1 Reply Last reply Feb 12, 2025, 4:20 PM Reply Quote 0
            • H
              Hearthfire
              last edited by Feb 11, 2025, 11:34 AM

              I've grown basil the last few years, it's amazing in stir fry. I got almost addicted to it, I wonder if my body was craving the effects it was having without me consciously noticing 🤔

              I know what I'm definitely growing again this year 😁
              I'll probably do italian basil and holy basil to test out both.

              M 1 Reply Last reply Feb 12, 2025, 4:21 PM Reply Quote 0
              • M
                Mauritio @cs3000
                last edited by Feb 12, 2025, 4:20 PM

                @cs3000 said in Holy Basil: Phyto-TESTOSTERONE, Progesterone and thyro-mimetic ?:

                @Mauritio
                looks best trying close to sleep / or before last meal with carbs with the glucose effect, if theyre similar here maybe it wore off and caused lower gaba activity through the night? if dosed high the rebound could hit excessively looks potent

                In this study O .basilicum extract had sleep benefits in menopausal women. Dosage: 250mg extract.
                https://pubmed.ncbi.nlm.nih.gov/36750371/
                Although in this study it showed no effect on sleep.
                https://pmc.ncbi.nlm.nih.gov/articles/PMC11795059/

                so shows 1g of dry plant powder is too low for effects. i have effective dose of dried leaves powder at 2.5g - 7.5g

                Even the microdose (30mg) caused waking up to early for me. It felt like hypoglycemia, woke up with a pounding heart.

                But maybe you're onto something with the GABA theory. GABA rebound is real.

                I obtained dried powder of both basils and will continue experimenting.

                Dare to think.

                My X:
                x.com/Metabolicmonstr

                1 Reply Last reply Reply Quote 0
                • M
                  Mauritio @Hearthfire
                  last edited by Feb 12, 2025, 4:21 PM

                  @Hearthfire nice they used fresh basil in some studies so that's probably the best way to go!

                  Dare to think.

                  My X:
                  x.com/Metabolicmonstr

                  W 1 Reply Last reply Feb 13, 2025, 5:33 PM Reply Quote 0
                  • W
                    wester130 @Mauritio
                    last edited by Feb 13, 2025, 5:33 PM

                    could the alcohol tincture be used topically?

                    1 Reply Last reply Reply Quote 0
                    • M
                      Mauritio
                      last edited by Mar 2, 2025, 11:38 AM

                      Yesterday I did 1g of basil (O. Basilicum)powder.

                      I took it in the morning and it had a strong relaxing /anti cortisol effect on me.
                      Muscles looked very full and less water retention as well.
                      During the afternoon I became a bit irritable and serotonergic ,but not sure if related at all. Might be due to gut issues from the day before.
                      I also felt quite confident and masculine. Totally recommend. Will try again .

                      And the best part was it didn't mess with my sleep like in my previous experiments with holy basil.
                      It was a bit harder to fall asleep but I didn't wake up early.
                      Maybe that was because it was basil and not holy basil this time, but maybe it was me taking it so early that the GABA rebound was over when i went to sleep.
                      I also took some limonene in the evening which increases GABA so maybe that flatened the GABA issues.

                      Today I woke up weighing 500g less and muscles looking Big and full . I had no morning wood today which is unusual . But some androgenic substances do that to me.

                      I still want to try 500mg and 25mg to see how that feels in comparison.

                      Dare to think.

                      My X:
                      x.com/Metabolicmonstr

                      H 1 Reply Last reply Mar 2, 2025, 4:57 PM Reply Quote 0
                      • H
                        Hearthfire @Mauritio
                        last edited by Mar 2, 2025, 4:57 PM

                        @Mauritio Interesting. Keep us posted.

                        I gotta order a bunch of seeds soon. I'm gonna grow a ton of it to experiment with and put in stir fry.

                        1 Reply Last reply Reply Quote 0
                        • L
                          lobotomize-me
                          last edited by Mar 17, 2025, 3:40 PM

                          Just bought 4 basil plants and whenever i eat couple g of basil my voice drops extremely low, never seen such crazy effects in my life.

                          M 1 Reply Last reply Mar 17, 2025, 6:24 PM Reply Quote 0
                          • M
                            Mauritio @lobotomize-me
                            last edited by Mar 17, 2025, 6:24 PM

                            @lobotomize-me nice any other androgenic effects?

                            Dare to think.

                            My X:
                            x.com/Metabolicmonstr

                            L 1 Reply Last reply Mar 17, 2025, 10:56 PM Reply Quote 0
                            • L
                              lobotomize-me @Mauritio
                              last edited by lobotomize-me Mar 17, 2025, 10:59 PM Mar 17, 2025, 10:56 PM

                              @Mauritio I had a game on the first day I took basil. You can read more about my experience in my other post. Although the game started off badly, on the way there I was super confident, joking with friends, feeling what i can describe as a extremly dht dominant state, and I truly felt like a "ruler" instead of a sheep.

                              The confidence seemed to fade during warm up, I wasn't unconfident, just silent and passive mentally. Even if I made a mistake, I didn't care too much what i felt could be described as a seratonin dominant state , putting my head down (I'm still trying to understand why this happens). When the game began, I fell into an extremely seratongenic state where everything just happened around me. I lost the ball multiple times and performed poorly(with hindsight i can remember me thinking as if i am in a cage trying to survive), so I asked my coach to substitute me off.

                              I talked with him and requested to be put back in after a few minutes he complied. Seeing my team struggle on the field made me angry and motivated. I told my coach I was ready, he put me back in, and then I dominated the other team.

                              At that moment, I genuinely felt like a ruler I can't fully describe it, but it felt incredible. I played amazingly, felt highly confident, had a high drive, commanded my team with helpful feedback, and overcame mistakes quickly. I'm not sure if basil had anything to do with this, but this was my full experience after taking sweet basil(High confidence/DHT dominance, although when faced with physical and mental pressure, suffered from a serotonergic state).

                              (Hope you can also help me figure out how to replicate the experience I had the second time I was substituted in and help me avoid entering the sheepish state of mind)

                              M 1 Reply Last reply Mar 18, 2025, 9:27 AM Reply Quote 0
                              • M
                                Mauritio @lobotomize-me
                                last edited by Mar 18, 2025, 9:27 AM

                                @lobotomize-me Interesting. Hard to say.
                                I wouldnt take it right before a game tbh. Its too anti-cortisol. The serotonergic state you describe could simply be that : no energy due to lack of cortisol. That can make you pretty fatigued when T3 isnt there to pick you up.

                                Maybe try the night before the game.

                                Dare to think.

                                My X:
                                x.com/Metabolicmonstr

                                L 1 Reply Last reply Mar 19, 2025, 1:40 PM Reply Quote 0
                                • L
                                  Luke
                                  last edited by Mar 18, 2025, 11:01 AM

                                  After reading the reports in this thread I bought a box with some dried basil powder, the one you can find in every grocery store among the spices. I'm not sure if it's as potent as fresh basil or concentrated powder, but I notice that I'm more relaxed and less stressed afterwards. I just take about a teaspoon and chew on it for two or three minutes before I swallow it (I find the taste quite pleasant and could imagine that the ingredients are good for the teeth, although that's speculation). Basil definitely peaked my interest.

                                  I also bought the tulsi extract from Sunday Naturals that @Mauritio mentioned in this thread. The results are more mixed. The first day I took an entire capsule around noon and didn't notice much. Felt stressed beforehand and felt stressed afterwards. With smaller doses it gives me a relaxing effect. I wonder why the tea gives me better results. Maybe it's just the dose and the dose of a full capsule is just too high. Last Sunday I made a camomile tea and poured the content of a tulsi capsule into the cup as well. I slept pretty well that night (by my standards). There seems to be something about tea that agrees more with me than a concentrated powder. Maybe I was an Englishman in a former life.

                                  War is when a government tells the people who is the enemy. Revolution is when the people work it out for themselves.

                                  1 Reply Last reply Reply Quote 0
                                  • L
                                    lobotomize-me @Mauritio
                                    last edited by Mar 19, 2025, 1:40 PM

                                    @Mauritio but wouldnt me being/feeling as if i am a sheep in a cage indicate that i have too much cortisol/stress?

                                    Plus i just realised the active compound in basil is rosmarinic acid which i saw you mentikned in another thread is Immunosuppressive

                                    M 1 Reply Last reply Mar 19, 2025, 3:40 PM Reply Quote 0
                                    • M
                                      Mauritio @lobotomize-me
                                      last edited by Mar 19, 2025, 3:40 PM

                                      @lobotomize-me yeah it would . But maybe it's from something else.

                                      Why is rosmarinic acid the main active component ?

                                      Dare to think.

                                      My X:
                                      x.com/Metabolicmonstr

                                      L 2 Replies Last reply Mar 21, 2025, 1:56 PM Reply Quote 0
                                      • KvirionK
                                        Kvirion
                                        last edited by Mar 20, 2025, 10:18 PM

                                        Just a field report...
                                        I tried Holy Basil today. I didn't notice much effect.
                                        Probably, some anti-inflammatory (maybe TSH lowering one?) and a bit cortisol/adrenaline lowering one, but since I have my cortisol pretty under control this wasn't any significant change.
                                        No change in body temperature or libido.

                                        A little learning is a dangerous thing ;
                                        Drink deep, or taste not the Pierian spring :
                                        There shallow draughts intoxicate the brain,
                                        And drinking largely sobers us again.
                                        ~Alexander Pope, An Essay on Criticism

                                        M 1 Reply Last reply Mar 21, 2025, 11:12 AM Reply Quote 0
                                        • M
                                          Mauritio @Kvirion
                                          last edited by Mar 21, 2025, 11:12 AM

                                          @Kvirion thanks for sharing. Maybe sweet basil will work better.

                                          Dare to think.

                                          My X:
                                          x.com/Metabolicmonstr

                                          KvirionK 1 Reply Last reply Mar 21, 2025, 12:12 PM Reply Quote 0
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