Pro Metabolic Substances Tier List
-
@LetTheRedeemed it’s not even the plateau, it’s just I had so much weight and to lose and only trialed it for half a year. I wasn’t even weighing my self and was eating high salt & protein diet slowing down things even more. I think it might of blunted dopamine that’s the only side effect I MAY of noticed
-
@alfredoolivas ok cool. thanks for sharing
-
Semigultide is not "pro-metabolic" by any stretch of the matter. If anything, it's the complete opposite. I can guarantee Peat would be against them as they slow gastric emptying. Not saying that don't have a place in weight loss
-
@risingfire you know, I’m just throwing out a confounder here so if there’s any counter data I welcome it.
As I began fixing my extremely outta wack hormonal profile, my bile dumps and frequent loose-stool movements, solidified and became harder to pass, and now thyroid/pro-metabolic stuff like cascara sagrada make that fast and painless, sometimes wipeless poos. Now, when I have a stress event, I may have loose bowel movements day of, and slow solid movements the next day. Basically, this looks like i’ve finally cracked the serotonin dominance that was maintaining gut motility, and now must improve the pro-thyroid parasympathetic system for gut motility.
Could this be what’s happening with the semiglutide reaction?
-
@LetTheRedeemed I'm not entirely sure. I took reta and noticed some interesting effects. My digestion was better but I was eating wayyyy less. Had wipeless poos but I felt off and my testosterone dropped big time. When I finally got off it, I paid the piper. And it was serious. I gained way more back than I lost. I believe it had to do with the stress effect of the glucagon action portion.
Are you still taking ozempic it or did you get off?
-
@alfredoolivas Why would anyone touch GLP's when we already have clenbuterol and the ECA stack that can be recreated with OTC ingredients?
In time there is life but no knowledge; outside time there is knowledge but no life
-
@jamezb46 Are you kidding?
-
@risingfire I never took ozempic (or anything more than bromo, cypro, and thyroid) as I understood it, semaglutide lowers glucagon and sensitizes cells to insulin glucose dependent insulin secretion, which is in fact antagonistic to glucagon, this much is very peaty. I didn’t know the details, so I googled it:
semaglutide:
In pancreatic β-cells, this signaling cascade also enhances glucose-dependent insulin secretion and sensitivity of peripheral tissues to insulin. Simultaneously, semaglutide suppresses glucagon secretion by pancreatic α-cells, contributing to improved glycemic control.Retatrutide does a few things:
Stimulate GIP… Glucose-Dependent Insulinotropic Polypeptide (formerly Gastric Inhibitory Polypeptide)
Retatrutide is referred to as a "triple-G" agonist, it works by mimicking three hormones: GLP-1, GIP, and glucagon.
Increased GIP associated with obesity activates the GIP receptor expressed by the hypothalamus, which in turn stimulates the cAMP-EPAC-RAP1 signaling cascade. Activation of the pathway results in the induction of SOCS3 and reduces neural leptin and insulin actions.Semaglutide lowers glucagon, increases insulin. This should not lower metabolism, but increase it.
retatrutide Raises glucagon and GIP, which lowers the hummer hormone and stimulates glucagon whilst suppressing insulin. This would truly slow metabolism.
-
@jamezb46 read my comment to risingfire and see what you think. Good to know about clenbuterol. Ray was a fan of epinephrine/noradrenaline for weight loss, and believed it’s reported negative effects were confused adrenaline as adrenaline rarely rises without noradrenaline too. Mild workouts that increase the heart rate without hyperventilation for instance, raise noradrenaline.
I’m interested in earning if there are any complications with clenbuterol
-
@alfredoolivas I wonder if long term use of a glp with intermittent use of bromo or caber could help…
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Register Login