Brother is having month-long psychotic episode after "Peating"
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Classic serotonin syndrome. Can be caused by drug-interactions between anti-histamines and any number of the things he's been taking.
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@NangaParbat How are you so sure it was serotonin syndrome and not psychosis, schizophrenia being triggered by the THC and research chemicals that alter neurochemicals in the brain?
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@Sugar I mean that serotonin syndrome was the cause of the psychosis. Anti-histamines can cause hallucinations in themselves in large doses. The symptoms of psychosis are closely tied to serotonin. But as you may know cyproheptadine is a standard treatment for ss, but in the case where the ss follows from an overdose of anti-histamines, this must of course not be the line of treatment. Nicotine is another problematic compound in this context, which is best avoided.
Good luck!
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@brotherwentcrazy I would recommend stopping all supplements yeah, but I don't think just stopping them will be enough to get him out of it. Once you get this kind of nervous stress reaction in you, that's how you'll be responding from now on unless you change it, it's just the imprint he has in him.
If I were in his shoes I would drink 2Ls of 1% milk a day (it lowers PTH), take vitamin D and take progest-e (instead of progestene, it genuinely makes all the difference). Orally is fine but if you applied progest-e topically onto the veins of his arms, it should bring relief.
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@brotherwentcrazy I'm so sorry for your brother's dire state and I hope he recovers quickly. I lost my brother to schizophrenia 15 years ago. He was 56. He had mercury amalgam fillings placed when he was a child. I did too. Mercury toxicity sets a person up to be thiamine deficient. It also causes selenium deficiency.
Safe removal of the amalgam fillings is paramount.Another thing that can exacerbate thiamine deficiency is polyunsaturated fats; another thing is the popular empty calorie western civilization diet, especially consuming fast food that is cooked with polyunsaturated fats.
Some thoughts:
It seems that many people that decide to jump into "Peaty" things and rely on second hand information rather than reading Ray Peat's articles can get into trouble. If your brother was consuming higher amounts of sugar and high sugar foods (like starch, fruit juices, etc.) and drinking coffee too, he could have exacerbated a latent thiamine deficiency. Thiamine deficiency can cause psychotic breaks by causing oxygen/cellular energy deficiency in the brain. If the doctors consider the possibility of thiamine deficiency contributing to your brother's problem, they could give him thiamine hcl by injection, which is the common way physicians administer it. An injection would have positive results quickly and would shed some light on what the problem is.I've seen that other posters are suggesting the problem could be from serotonin overload; I'd like to add that thiamine is required to clear serotonin from the brain.
Suggested reading:
https://www.hormonesmatter.com/serotonin-syndrome-thiamine-connection/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459027/
https://www.psychologytoday.com/us/blog/evolutionary-psychiatry/201204/nutritional-brain-bomb-thiamine-deficiency
https://www.degruyter.com/document/doi/10.1515/jbcpp-2018-0075/html?lang=en -
@eric So what? Schizophrenia still has biochemical causes, it doesn't just spring out of nowhere. There is no clock inside of a baby counting down until it's time for schizophrenia.
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i have a friend diagnosed with schizophrenia who hasnt had any psychotic episodes since changing his diet a few years ago. taking all those supplements with any nutritional deficiencies would probably be catastrophic for most people even if it was just chronically irritating his intestines and lowering his blood sugar. just taking the tyronene without enough carbs could cause something like this.
i wouldn't discourage him from the path he is on, he just tried to take a shortcut with bulgarian research chemicals, i have done the same thing. he will probably realize at some point he needs to focuses on the basics (diet, blood sugar, gut, thyroid) and be patient.
definitely should not smoke weed or drink if he has a tendency towards psychosis.
your brother can recover from this though, 24 is young. my "schizophrenic" friend has really interesting perspectives on life and is one of my favorite people to talk to.
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Sorry to hear that. Combine THC and Metergolin is definitly not something you want to do. Or even THC + Cyproheptadine. Playing with hormones and GABA and Dopamin agonist is not something to take like a game especially after 3 months of "peating". I would consider first stopping everything, and then start to only work in increasing metabolism step by step and not try to combine all these tools when you don't know what you are taking. These products are supposed to be for research only and if someone use them for himself he must know what he is using, why, when in which dosage.
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What was his diet?
Did he have a lot of energy drinks and if so which ones?
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It’s def the mix of all those things at once. I’d recommend looking into Maurice Cotterell’s work. We’re approaching solar maximum and that can really induce some unpleasant changes if the body isn’t capable of adapting and diet and environment aren’t supportive.
In online esoteric circles it’s talked about as spoantaneous kundalini. Itzhak Bentov studied it and explained about it in his book Stalking the Wild Pendulum. Physio-kundalini syndrome.
People experiencing this are stuck between different levels of reality and their nervous system isn’t capable of filtering out things and translating it into helpful information.
Bentov and other great minds learned to balance it.
Julian Jaynes is also an excellent read on schizophrenia and brain hemisphere cooperation. Iain McGilchrist for a more contemporary cultural context. -
Sorry to hear this has happened. I know from watching friends and family members who have gone through this that it is very difficult for all involved.
THC by itself may have caused this. It is responsible for more trips to the psych ward than any other drug by a wide margin. THC gummies are notorious for improper labeling. We don't know if he was having the equivalent of a "beer after work" or if he was on a major bender. Him being in his early-to-mid 20s with a history of drug use (family history of mental illness?) makes him a statistic when it comes to schizophrenia diagnoses.
The less bad news is that it sounds from your post like your brother's experimentation with his serotonin status pushed him over the edge. This means he can likely recover fully given a proper recovery protocol. To any Bulgarians-in-waiting, you need to be a Level 5 Peater before your stack gets that big.
Practically speaking, has your brother been diagnosed as schizophrenic or with anything in particular? This impacts what public or hospital resources might be available to you/him. Healthcare "practitioners" can't help you through the bureaucracy. If a social worker is involved, he or she is a great person to ask about what you can do as a family. I mention this because the emotional strain on family relationships is severe in cases like this and because your brother will one day soon be off of whatever wild meds they have him on now and coming off of those is hard. The trick right now may be to find him treatment/ a place to stay until he can get medical assistance, since he has no income.
