A combination of vitamin B1/B3/B7 and aspirin, has curative effects on human mantle-cell lymphoma
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Do you have details on why such specific dosages of aspirin and these vitamins is what works? Seems like there is potential for some fascinating interactions at play.
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Good job Georgi!
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@Vineland I'm wondering this as well, specifically the reasoning behind such a high dose of biotin.
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@haidut Sounds promising? Do you think things like Lactoferrin or IP6 can help?
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Really happy to see Georgi already here
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@haidut hello
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@haidut are there any plans to increase the sample size going forward? what would it cost to run a trial on say, 50 mice?
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P pilky pinned this topic on
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Question is wether there is a difference between different forms of B1
TTFD is pretty potent, but generallys we need less of it because absorption
Is there any specific reason for Thiamine HCL over TTFD or benfothiamine?
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@ElijahKrings Elliot from EONutrition has many good videos explaining the differences on his youtube channel
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@Dakota there was an older study on the old forum where b1 and b7 together restored glucose oxidation. Im assuming its pure Warburg effect
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@haidut Groundbreaking work! Were going to look back at this study to "where it all began"...hopefully.
Im wondering if the addition of biotin (and maybe aspirin) was the deciding factor? IIRC your earlier studies had less of an anti-tumor effect and did not include biotin.
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@RePeat Looks like there have been some related studies posted about the topic, thanks m8.
https://raypeatforum.com/community/threads/using-vitamins-biotin-for-improving-glucose-control.5862/
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System unpinned this topic on
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@haidut I hope you stick around. I see you started posting on RPF again after being unbanned. Which is fine, but I think we all see the writing on the wall for that place.
Good work on the study.
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There are studies on each of these vitamins for cancer or other serious diseases, so I based the dosing on that, but also tried a few experiments with lower and higher doses and this is the dose for the vitamins that worked best. The aspirin dose is also based on an animal study with cancer, I think it was liver cancer, and the animals were fully cured.
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I answered the dosage question in a previous comment/response. The biotin dose may look large, but it is actually lower than the doses currently tried in human studies for multiple sclerosis or Huntington disease (300mg daily). In fact, I tried a higher dose biotin with the same cancer line and the results were not better, but actually slightly worse. So, it is all based on prior studies published by others, current clinical trials, and also my own experiments with lower/higher doses until I find out what works best for each vitamin.
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The 6g+ Ray mentioned was when aspirin it used by itself. However, the combination of the B vitamins, in those doses, has a number of effects that are strongly anti-cancer and would allow for lower aspirin dose to be used. Vitamin B1 is a PDH activator, and also carbonic anhydrase inhibitor, both of which have been shown to be therapeutic in cancer. Niacinamide raises NAD+/NADH ratio, is anti-inflammatory, and inhibits excessive fatty acid oxidation, both of which have been shown to help with cancer. It is also a PARP-1 and CD38 inhibitor and those pathways are already used to treat cancer. Finally, biotin has been shown to raise CO2 levels, bypass any blockage in PDH and improve mitochondrial function, which is why a high-dose biotin (300mg) is currently in human trials for multiple sclerosis, huntington disease, and I diabetes all of which share many commonalities with cancer.
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IP5 has impressive reports, including complete reversal or metastatic/terminal melanoma in a human patient.
https://pubmed.ncbi.nlm.nih.gov/30615010/But if the protocol works, there is no need to add another ingredient. Occam's rule and all that. Though it is nice to have a list of alternatives to try if the effect is not strong enough in some people.
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Yes, it will be tried again with 3 groups of 5 mice each - one control, one "standard of care" treatment, and one with the vitamins/aspirin. The initial studies are all small to keep costs low and to discover what MAY work. There is no need to do 50 mice, in animal studies 5 mice per group is enough and if the second study also shows complete cure while the control and standard group all die, then it is hard to argue it is an anomaly, especially if it is a repeated occurrence/result. Also, I will try a few other cancer types and different species (hamster, rats, etc) and if it works there too, then it is pretty clear the mechanism is very broad/systemic and not tumor-dependent and not species-dependent, in which case it becomes almost irrefutable that whatever mechanism this works through is very systemic and also that cancer is NOT a genetic disease.
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I already did a prior experiment with the same tumor line but the B1 used was prosultiamine instead of thiamine Hcl. The results were identical with the thiamin Hcl experiment. So, I decided to use thiamine Hcl going forward precisely because it is so cheap and widely available and it is legally almost impossible to ban. Prosultiamine can easily ve declared a drug and pulled off the market. It has already happened in several Asian countries with other B1 analogs such as sulbutiamine.
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Yep, one of the reasons why I included both. There are studies for each individually regarding glucose oxidation and CO2 levels, and there is also a study showing synergistic effects when combined.
