7-keto DHEA
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Is it Peaty and/or worthwhile?
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@Nomanarch For women yes not so much for men
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@jamezb46 why? I don’t think it has any impact on sex hormones. Apparently increases metabolic rate, used for weight loss.
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Because it is a weak androgen. Men have about 10-20 times more androgenic signaling at baseline than do women so any additional androgens in women will have a huge difference for them.
For example, 500 mcg of testosterone every day will have noticable effects on women but not on men.
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Post in thread 'Ray Peat Email Advice Depository'
https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-358649_ Do you think the addition of keto groups to hormones can make them negative and why? I remember that in the past you told me you wouldn't use them.
_ Yes, I think large doses of any modified progesterone could be harmful to the brain.
_ Thanks for the answers, that helps.
Is there something inherent to the addition of a keto group from a biochemical standpoint that would make bio-identical keto varieties of any steroid harmful? [...]
Or did you see specific studies on keto progesterone which raised concerns?
cleardot.gif_ It’s that progesterone has extensive functions that are essential for survival in good health, and something which closely resembles its structure is likely to interfere in those processes. It could take years for irreversible and disastrous effects to be noticed.
cleardot.gif
_ Thanks.
You mentioned big doses would cause that, any idea what may be dangerous territory? So far I've only heard about 11 k progesterone and 6 k progesterone.
What about 11 k dht, would that be any different?_ I think there’s too little information to judge the risks confidently; I would want at least some good long term animal studies before I tried one of them.
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Post in thread 'Ray Peat Email Advice Depository'
https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-285682Wagner: "Hey , I'd like to know what do you think about 11-keto-dht, does the addition of the ketone group makes it more toxic? Half life is longer which sounds like a good idea, it is naturally present in the body and a strong androgen. By the way there is this paper ( Feed-forward control of prostate growth: dihydrotestosterone induces expression of its own biosynthetic enzyme), on how dht stimulates its own synthesis.."
Ray: "I think it’s risky to supplement hormonally active intermediates in steroid metabolism, since it can have widespread unexpected effects.
W: "Ok thanks, I thought dht and 11-keto-dht were end point steroids (Hans selye work on combining upstream and end point steroids is interesting) , does that mean you would not supplement with androsterone either?"
R: "I think I might use DHT, but not androsterone or the ketos."
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Post in thread 'Ray Peat Email Advice Depository'
https://lowtoxinforum.com/threads/ray-peat-email-advice-depository.1035/post-655036Q: Mr Peat what do you think about androsterone and 11 KETO dht
A: Not sufficient research to know of safety. -
@16characterstwas thank you very much
