Vit E and Vit K
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Word to the wise, vitamin E can antagonize the clotting action of Vitamin K. If you’re going to take aspirin I’d stay away from Vitamin E.
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@EagleTwoRomeo yeah they both thin the blood. Aspirin and vitamin e that is.
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Useful links on liposoluble vitamins
*) Vitamin A, D, E & K - How Much and What Type of Fat Do You Need to Absorb These Fat Soluble Vitamins?
http://suppversity.blogspot.be/2014/05/vitamin-d-e-k-how-much-and-what-type-of.html*) Taking high dose vitamin K
“High dose of vitamin K could prevent us from using osteocalcin.” Chris Masterjohn.
doi: 10.1186/1475-2891-13-85
=> Menaquinone-4 supplementation at 600 μg/day or more is likely to be important in terms of vitamin K requirements for bone health (range 600 – 1500 mcg K2 MK4).*) Effective minimum dose of dietary MK-7 to affect carboxylated osteocalcin/undercarboxylated osteocalcin ratio in blood.
https://www.jstage.jst.go.jp/article/jnsv/61/6/61_471/_pdf
The present study demonstrated that ≥ 100 mcg K2 MK7 in addition to ordinary meals could improve osteocalcin y-carboxylation status.
Comment:
Of course, taking 15 mg K2 (15 000 mcg) when 2 x 1 mg MK4 could do the job, is kindly different.
Aspirin is ok when taking HD K1 (coagulation not desired).
Info on absorption, target and dosage of vitamin K (and links from Chris Masterjohn and Kate Rheaume-blue) (in French, with English links)
https://mirzoune-ciboulette.forumactif.org/t1704-vit-k-mk4-vs-mk7-update-02-2020#21497*) Excess quinones overburden the detox pathway Cyp450
Too much quinone is not advised. Same family as tocopherols (Vit E), menaquinones (Vit K2), PQQ or Co-enzyme Q-10 (Q10).
Note: No problem with 2 mg K2 MK4 (2 000 mg), taken separately (at a different meal), but if you combine several supplements, you’d better get informed which molecules could interfere with the detox pathway Cyp450.
Cyp450 detox pathway: https://www.geneticlifehacks.com/liver-detox-genes/
Same subject, in French, but with personal comments:
Voie de détoxification & CYp450
http://mirzoune-ciboulette.forumactif.org/t1609-voie-de-detoxification-cyp450#19224*) 2 x 400 UI mix toco is enough!
- I never take Vit A supplement at the same time as the other lipovitamins. Nor vit D with K at the same meal since we need a lot of fat to absorb Vit K (35 gr lipid is optimal: 14 – 25 – 35 g fat are thresholds impacting the degree of absorption. I target minimum 25 g fat).
- Vitamin E and K share similar transporters/metabolizing enzymes. When high dose Vitamin E is given it may block the transporters/enzymes that are needed to integrate Vitamin K into the appropriate tissues.
Moreover high dose Vit E, K, Q10 and polyphenols leaves quinones but our liver has a limited capacity to deal with. - Vitamin E decreases extra-hepatic menaquinone-4 concentrations in rats fed menadione (K3) or phylloquinone (K1)
http://www.ncbi.nlm.nih.gov/pubmed/22707266
*) Interaction
Synergy effect with vitamin E
“Vitamin C regenerates vitamin E and vitamin E protects β-carotene, helped in this by polyphenols. In the event of β-carotene supplementation, vitamin C regenerates vitamin E and β-carotene, and β-carotene seems to protect vitamin E without really explaining this phenomenon "(1)
Savings effect
Vitamin E is not just a vitamin. Vitamin C makes it possible to recycle oxidized vitamin E and thus prolong its lifespan. The same goes with glutathione which is thus saved for other more useful functions (detox). Glutathion is our antioxidant master. Vitamin E protects against the deleterious effects of polyunsaturated fatty acids when the latter are in excess. And it is quickly done!- John Libbey Eurotext - Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions. Auteur : Claude Louis Léger.
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Vitamin E and Vitamin K both play critical but opposing roles in blood clotting—Vitamin K promotes clotting, while high doses of Vitamin E can inhibit it by interfering with Vitamin K's metabolism and transport. If you're taking aspirin (a blood thinner), combining it with high-dose Vitamin E can increase the risk of bleeding. A safer approach is to moderate Vitamin E intake, avoid taking it at the same time as Vitamin K, and ensure adequate healthy fat intake to aid absorption of fat-soluble vitamins. Always consult a healthcare professional before combining supplements with medications.
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@LucH said in Vit E and Vit K:
*) Taking high dose vitamin K
“High dose of vitamin K could prevent us from using osteocalcin.” Chris Masterjohn.
doi: 10.1186/1475-2891-13-85
=> Menaquinone-4 supplementation at 600 μg/day or more is likely to be important in terms of vitamin K requirements for bone health (range 600 – 1500 mcg K2 MK4).game changing stuff
