Dealing with Fatigue

Ismail

@mostlylurking thank you ever so much, this is extremely helpful and beneficial!

How did you know your glutathione levels were low?

@mostlylurking thank you ever so much, this is extremely helpful and beneficial!

How did you know your glutathione levels were low?

Blood testing. My glutathione level was low for many years due to high oxidative stress caused by mercury toxicity from childhood mercury amalgam fillings.

After 6 months of taking high dose thiamine hcl my glutathione level tested in the normal range. Glutathione is very important and notoriously difficult to normalize if deficient.

I did try taking TTFD but one capsule gave me a bad headache that lasted 36 hours. Elliot Overton has an article about the glutathione issue associated with negative reactions to TTFD. He advised in a video that thiamine hcl would improve glutathione status. He was right about that.

see here: https://www.hormonesmatter.com/paradoxical-reactions-with-ttfd-the-glutathione-connection/

Loulou

@mostlylurking: hi, don't you recycle time to time. For example, me, I don't like to be dependent on supplements and tend to prefer a food source like liver for the b vitamins, oysters (, copper, irons and minerals), if I eat meat, I add eggshells powder for more calcium on my coffee, and I do take thyroid (cynoplus and cynomel) if I feel symptoms during my luteal phase (2 weeks before my periods).
I think I will try to do one week of b vitamins (b1 hcl, B2, B3, b5, biotin and b6) to recharge my batteries once every 3 months.

May I know why you don't recycle and take it all year long?

@Loulou said in Dealing with Fatigue:

@mostlylurking: hi, don't you recycle time to time. For example, me, I don't like to be dependent on supplements and tend to prefer a food source like liver for the b vitamins, oysters (, copper, irons and minerals), if I eat meat, I add eggshells powder for more calcium on my coffee, and I do take thyroid (cynoplus and cynomel) if I feel symptoms during my luteal phase (2 weeks before my periods).
I think I will try to do one week of b vitamins (b1 hcl, B2, B3, b5, biotin and b6) to recharge my batteries once every 3 months.

Suit yourself.

May I know why you don't recycle and take it all year long?

I've been in poor health for decades; I'm 74. I've studied Ray Peat's written work and have been following his advice intensively for 10 years. But I was still unwell because I've got heavy metal poisoning (mercury from childhood amalgam fillings). I finally found something that actually works (high dose thiamine hcl). I see no reason to stop taking it; thiamine hcl is considered a "safe" supplement. If I forget to take it for a day, I become constipated and incontinent because my autonomic nervous system doesn't work like it should without the high dose thiamine + magnesium. I prefer being able to function and to feel good enough to go outside and dig in my garden.

The only prescription drug that I take is 135mgs of NP Thyroid by Acella, a desiccated thyroid product that actually works.

Spend a little time and watch Dr. Costantini's patients' before and after treatment videos here. Information about Dr. Costantini is here.

Here is a short interview of one of Dr. Costantini's patients; maybe this will help explain why I keep taking high dose thiamine hcl. Although I never got the official diagnosis of Parkinson's Disease, I was very sick with all the symptoms of Wernicke's Encephalopathy and had developed a tremor in my right hand (no more).

Loulou

@mostlylurking aw, I am sorry for all your health issues. I must say that I am quite lucky after a few health woes that my health is in a good place now. But I am much younger than you, and I have been peating for a few years now which has helped tremendously.

I am glad you have found something that is working for you. Ok, I will watch a few of Dr Constantini's videos. Thank you for the links.

I intend to watch Chris masterJohn as well. Apparently he is quite peaty as well.

@Loulou said in Dealing with Fatigue:

@mostlylurking aw, I am sorry for all your health issues. I must say that I am quite lucky after a few health woes that my health is in a good place now. But I am much younger than you, and I have been peating for a few years now which has helped tremendously.

I am glad you have found something that is working for you. Ok, I will watch a few of Dr Constantini's videos. Thank you for the links.

I intend to watch Chris masterJohn as well. Apparently he is quite peaty as well.

Peat did speak favorably of Chris Masterjohn. I think exploring other people's work can be very helpful. Discernment is a critical life skill. I've found Elliot Overton's work very helpful, also Dr. Derrick Lonsdale, also Dr. Chandler Marrs. Articles by these people are available at hormonesmatter.com . When in doubt I tend to rely on Ray's ideas, especially regarding thyroid and hormones.

Ismail

@mostlylurking thank you, yes I’ve seen Elliot’s video on the same topic - think it’s called paradoxical reactions or something similar. I’ve also bought the book which Elliot refers to and how he got into thiamine etc. (The one by Dr Lonsdale and Chandler Marrs), never had the chance to read it though.

I think I’m gonna try and experiment with the HCL version and see how I get on.

@Ismail said in Dealing with Fatigue:

@mostlylurking thank you, yes I’ve seen Elliot’s video on the same topic - think it’s called paradoxical reactions or something similar. I’ve also bought the book which Elliot refers to and how he got into thiamine etc. (The one by Dr Lonsdale and Chandler Marrs), never had the chance to read it though.

I think I’m gonna try and experiment with the HCL version and see how I get on.

Dr. Costantini's website might be of interest to you as he always used thiamine hcl for his patients. Lots of good info there. His research papers are hiding under "Blog Posts" I wound up following his Therapy dosage amounts for oral thiamine hcl.

I just did a quick search and found this: https://www.researchgate.net/scientific-contributions/Antonio-Costantini-2004482521

Ismail

@mostlylurking will def check it out, thank you as always, much appreciated Have ordered some HCL version of thiamine, meant to arrive today.

@Ismail said in Dealing with Fatigue:

@mostlylurking will def check it out, thank you as always, much appreciated Have ordered some HCL version of thiamine, meant to arrive today.

Good deal! Continue researching thiamine, especially about things that deplete it/interfere with it such as: sugar, high carbs, coffee, black tea, sulfites, foods containing thiaminases. see here: https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/thiaminase

Lots of prescription drugs, including antibiotics, block thiamine function. Mine got blocked by Bactrim antibiotic. Things did not go back to normal after stopping the antibiotic and I got into real trouble; it took months to recover via high dose thiamine hcl.