Just found out I have reactive hypoglycemia. What now?

[yerrag]

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

Mercury evidently also distinguishes itself by causing selenium deficiency. Selenium is very important for health; it is needed to convert T4 into the active T3 (search for Selenium in the article); if you cannot convert T4 to T3, you are in big trouble.

I'm a believer. Once I noticed my cats got hyperthyroid. They both in a short time became thin from plump, from heavy eaters to hardly. They each had two lumps on their throat. I had cats die before but didn't notice this connection. I had slowly developed the habit of observing over the years, and had already read a lot of Peat's ideas, and gave each of them selenium which I had bought for myself. I am normothyroid, but I bought selenium in case something would go wrong with my intakes of iodine, which Ray was extremely cautious about. Overnight, the cats recovered.

[yerrag]

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

reason why I'm so pro thiamine is because it actually helped me. My chiropractor said to me, "you know you're messing with your electrical system, right?" And I did intuitively know that. There were shorts in my current (the power force that runs through all of us); taking high dose thiamine hcl restored my energy flow.

Please watch the before and after videos of Dr. Costantini's patients to visually see and better understand what I'm talking about. Maurizio's section includes an interview (with English subtitles!) which is very short and very informative. But watch Maurizio's Before video first. The Bruno series is very good and includes an interview with his wife. These are real people who were given their lives back via high dose thiamine hcl, by injection, but Dr. Costantini provided information about thiamine hcl oral dosage, which is what I follow

Say no more. I began a 1-week trial of 1500mg thiamine HCl last night. It isn't a big leap for me now as I've used 1000mg before and a headache I was having (I rarely have headaches and this stood out) quickly went away. At the time of my headache, my breath rate at 26 per minute meant my blood was very acidic, and I suspect my metabolism had turned glycolytic, and I had plenty of lactic acid in my blood with little space to spare for CO2. I was breathing in carbogen but it was having no effect as the high breathing rate was expelling the CO2 in carbogen I was breathing in. Thiamine, as I understand it, would convert lactic acid eventually to glucose in the liver thru the Cori cycle, I believe. And that is what I think happened. For on the same day, my headache was relieved as my breath rate went down to 16.

With more CO2 in my blood, my platelets could carry CO2, and serotonin to the CO2, and serotonin would be deactivated in my lungs, and there would little serotonin free to get into my brain. Not making this up, but this is the benefit from reading first hand Rayçs books and newsletters.

Thank you very much for taking the time to share with me the links. I'm sure they will be very helpful. Especially the ones on Parkinson's.

[A Former User]

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

you able to turn off the thinking or has it become circular?

I sleep. I take time off. It refreshes my mind. When stumped, I give up thinking and the next day I often have a solution. I am also self-aware that my thinking process does not become circular. I doubt in how I explain things that you would find evidence of circular thinking, but if you catch any, I would welcome pointing that out to me.

All very good! Your brain's working well. I suffered from circular thinking for many years. So did my brother; he showed me the condition of his mouth when he was 55; he still had all the amalgam fillings he got as a child. He was desperate to get the circular tick tick tick to turn off. I didn't know how to help him (this was 15 years ago). He committed suicide a few months later.

Intellectual pursuits where differences occur are a normal part of learning from each other, and even more common are where it leads to talking down to one another. It's not productive as I experience with @CO3. But that comes with the territory. At that point I would fold and wish such people a good life as everything is a waste after that.

If people always agreed, nobody would ever learn anything.

Trying to understand where the other person is coming from via an online chat can be difficult at times. Everybody isn't always playing with the same deck.

I'm not at all saying this to you and don't infer you are, as evidently you're not. And I'm not intending to patronize either when I say your dogged sharing of the benefits of using thiamine is admirable to a fault. Your insistence lets the hardened of heart open to the idea you espouse and that opens up a solution to be considered. But when one is so insistent that it is his way or the highway, and resorts to insults and to ad hominems, I know the best thing to do is to ignore him.

Sorry if I've been driving some to the brink.

I closely followed Ray Peat's written work for 5 years and some of my health issues did get a lot better, but what I was doing I think sabotaged me too. 5 years is a long time. Then, in 2020, I got really sick; I was borderline thiamine deficient even though I was taking 200mg/day of thiamine hcl (took it with OJ - oops). And then I took some Bactrim antibiotic (for a UTI) which nearly killed me because it blocked my thiamine function. Long story short, I tried some thiamine hcl with water and experienced massive improvement in 45 minutes. It made me a believer in what Elliot Overton, Dr. Lonsdale, Dr. Chandler Marrs, and Dr. Costantini were proselytizing about.

I hope we can agree that optimizing oxidative metabolism so that the body has enough energy to function properly and maintain repairs is key to health. Ray Peat's work is oriented in that direction. Because I read Peat's articles (multiple times) I caught some little things. One is that good thyroid function plus a good diet (devoid of PUFA) will result in good oxidative metabolism, assuming something else isn't blocking it.

One of those things that can block oxidative metabolism is thiamine deficiency. I know this isn't the case for everybody, but I also realize that some of the Peaty things that people do will lower their thiamine supply including: eating sugar/carbs; drinking coffee; avoiding nuts, seeds, grains, pork. A list for dietary sources for thiamine reads like a Ray Peat avoidance list.

I had a few email exchanges with Ray Peat. I remember him telling me in 2020 that if you've got heavy metal poisoning, all bets are off. This exchange occurred during the time I was trying not to die from the Bactrim debacle and my gut was just a mess and Peat was advising me to take thiamine hcl and magnesium to heal my gut. Ray was right about what I needed to take; I just needed a lot more of it than he suggested. But then, I have heavy metal poisoning, so all bets are off.

[A Former User]

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

Mercury evidently also distinguishes itself by causing selenium deficiency. Selenium is very important for health; it is needed to convert T4 into the active T3 (search for Selenium in the article); if you cannot convert T4 to T3, you are in big trouble.

I'm a believer. Once I noticed my cats got hyperthyroid. They both in a short time became thin from plump, from heavy eaters to hardly. They each had two lumps on their throat. I had cats die before but didn't notice this connection. I had slowly developed the habit of observing over the years, and had already read a lot of Peat's ideas, and gave each of them selenium which I had bought for myself. I am normothyroid, but I bought selenium in case something would go wrong with my intakes of iodine, which Ray was extremely cautious about. Overnight, the cats recovered.

Hah!! That's a wonderful story! I had cats for many many years; they're wonderful animals. The choices for cat food in the grocery store is just awful. Too much A, too much ash, too much pufa.

I've been taking selenium since last summer. I got blood work done late September and both of my doctors remarked on how much healthier I'd become.

Can you point me to reliable information about iodine? And what's the deal with getting selenium for your iodine intake?

[A Former User]

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

reason why I'm so pro thiamine is because it actually helped me. My chiropractor said to me, "you know you're messing with your electrical system, right?" And I did intuitively know that. There were shorts in my current (the power force that runs through all of us); taking high dose thiamine hcl restored my energy flow.

Please watch the before and after videos of Dr. Costantini's patients to visually see and better understand what I'm talking about. Maurizio's section includes an interview (with English subtitles!) which is very short and very informative. But watch Maurizio's Before video first. The Bruno series is very good and includes an interview with his wife. These are real people who were given their lives back via high dose thiamine hcl, by injection, but Dr. Costantini provided information about thiamine hcl oral dosage, which is what I follow

Say no more. I began a 1-week trial of 1500mg thiamine HCl last night. It isn't a big leap for me now as I've used 1000mg before and a headache I was having (I rarely have headaches and this stood out) quickly went away. At the time of my headache, my breath rate at 26 per minute meant my blood was very acidic, and I suspect my metabolism had turned glycolytic, and I had plenty of lactic acid in my blood with little space to spare for CO2. I was breathing in carbogen but it was having no effect as the high breathing rate was expelling the CO2 in carbogen I was breathing in. Thiamine, as I understand it, would convert lactic acid eventually to glucose in the liver thru the Cori cycle, I believe. And that is what I think happened. For on the same day, my headache was relieved as my breath rate went down to 16.

Good deal!!

a few links for your consideration:
Why does High-Dose Thiamine Relieve Fatigue in Individuals with Diverse Conditions? — Hypotheses Grounded in Thiamine’s Role as a Carbonic Anhydrase Inhibitor
also:
Letter: future studies of high-dose thiamine should consider whether its effects on fatigue are related to the inhibition of carbonic anhydrase isoenzymes

When cellular respiration is working well, the end product from burning glucose for fuel is carbon dioxide. That can't happen without thiamine. If the process is derailed (like in a thiamine deficiency), the end product is lactic acid.

With more CO2 in my blood, my platelets could carry CO2, and serotonin to the CO2, and serotonin would be deactivated in my lungs, and there would little serotonin free to get into my brain. Not making this up, but this is the benefit from reading first hand Rayçs books and newsletters.

Did you know that thiamine is needed to remove/resolve serotonin in the brain?

Effect of thiamine deficiency on brain serotonin turnover
also
Alterations in Serotonin Parameters in Brain of Thiamine-Deficient Rats Are Evident Prior to the Appearance of Neurological Symptoms

I suffer a slight degree of OCD about this brain/thiamine/serotonin topic, sorry. I was subjected to 3 years of Prozac then 9 years of high dose 5-htp prescribed by imbecile doctors before I found Ray Peat.

Thank you very much for taking the time to share with me the links. I'm sure they will be very helpful. Especially the ones on Parkinson's.

I'm so glad to have someone who is interested to share this stuff with!

[yerrag]

@mostlylurking I have a better term now for what I call Parkinson's, it is gait ataxia, and it is related to b1 deficiency, under the condition of dry beri beri. I have this symptom only when I was better, and prior to getting hospitalized, I had a lot of symptoms of wet beriberi, including heart failure.

https://samarpanphysioclinic.com/ataxic-gait/

I'm keeping this short, but the long and short of this is that I was actually experiencing both forms of beriberi. Somehow I didn't have enough thiamine, even though all this time I was taking 250mg of thiamine along with b3 and b6. Perhaps it was because I has been urinating a lot for so many years, and though I was fine having no beriberi, what pushed me over the edge was when last year I created a perfect storm unknowingly that affected my lungs causing acute bronchitis and while not dully healed I began my lead detox with Emeramide and the healing crisis that came about put my lungs in further stress.

It seemed to me I am paying a big price for ignoring you all the way back in RPF.

[A Former User]

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking I have a better term now for what I call Parkinson's, it is gait ataxia, and it is related to b1 deficiency, under the condition of dry beri beri. I have this symptom only when I was better, and prior to getting hospitalized, I had a lot of symptoms of wet beriberi, including heart failure.

https://samarpanphysioclinic.com/ataxic-gait/

I'm keeping this short, but the long and short of this is that I was actually experiencing both forms of beriberi. Somehow I didn't have enough thiamine, even though all this time I was taking 250mg of thiamine along with b3 and b6. Perhaps it was because I has been urinating a lot for so many years, and though I was fine having no beriberi, what pushed me over the edge was when last year I created a perfect storm unknowingly that affected my lungs causing acute bronchitis and while not dully healed I began my lead detox with Emeramide and the healing crisis that came about put my lungs in further stress.

Eureka! Yes, I think perhaps you've nailed it. The last straw was the assault on your lungs. You know, there's a high incidence of thiamine deficiency in the intensive care units of hospitals because the stress of surgery (or just being very sick) can cause thiamine deficiency. There's a reason that there's banana bags in hospital emergency rooms.

I'm very hopeful that you will be able to fully recover. Or at least achieve tremendous improvement.

from the link you provided:
"What is Ataxic Gait? A common feature of ataxic gait is the inability to walk straight ahead, as well as lateral veering, poor balance, a wider base of support, irregular arm movements, and lack of repeatability. These signs frequently reflect the way a person walks after drinking."

I had ataxic gait fall of 2020; I kept bouncing off the walls. I also developed a tremor in my right hand. But these resolved via high dose thiamine hcl. When I got so sick, I was taking thiamine hcl, 100mg, 2Xday, but I took it with orange juice (oops). Many of the patient Before Treatment videos show people having a hard time walking, so the Ataxic Gait seems to be a tell tale sign.

It seemed to me I am paying a big price for ignoring you all the way back in RPF.

But you're looking at some of the info I provided now and now you can take control of the situation and recover.

Dr. Costantini's FAQs were very helpful to me. You may find them helpful too. His research papers are hiding under Blog Posts on his site. His Therapy section provides good info including oral thiamine hcl dosage amounts.

It seems that all of the thiamine experts that I have relied on are clinicians; they all have had hands on experience treating actual patients rather than only being off in some laboratory working with test tubes and computers. There's tons of good research you can find on line about thiamine, but expensive double blind studies are scarce because no one can patent thiamine.

Elliot Overton counsels clients in nutrition. He has a lot of good videos about thiamine.

Dr. Chandler Marrs treats patients at her clinic.

Dr. Derrick Lonsdale was a pediatrician at the Cleveland Clinic. He's retired now, is over 100 years old, takes TTFD daily, and still responds to questions in the Comments (below the articles) at hormonesmatter.com.

Dr. Costantini (died 2020), treated thousands of Parkinson's Disease patients successfully in Italy with thiamine hcl.

Ray Peat mentioned thiamine multiple times in his articles and interviews. He also referred to it as "B1".

[yerrag]

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

banana bags

you mean for thiamine iv infusion?

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I'm very hopeful that you will be able to fully recover. Or at least achieve tremendous improvement.

I am very confident of this as well.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I had ataxic gait fall of 2020; I kept bouncing off the walls. I also developed a tremor in my right hand. But these resolved via high dose thiamine hcl. When I got so sick, I was taking thiamine hcl, 100mg, 2Xday, but I took it with orange juice (oops). Many of the patient Before Treatment videos show people having a hard time walking, so the Ataxic Gait seems to be a tell tale sign.

I just learned of the term "gait ataxia" or "ataxic gait.." Is this your first time to hear the term as well? Seems like had I know of this term earlier, I would not refer to it as "a symptoms of parkinson's" or "myasthenia gravis." As it would be easier to see it associated with beriberi and to vitamin b1 deficiency.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

It seems that all of the thiamine experts that I have relied on are clinicians; they all have had hands on experience treating actual patients rather than only being off in some laboratory working with test tubes and computers. There's tons of good research you can find on line about thiamine, but expensive double blind studies are scarce because no one can patent thiamine.

Very true! This is where the practitioners of "evidence-based" scientism lord it over clinicians all the time. Sad that a majority worship at the temple of scientism. The irony is that the more "educated" one is the more he relies less on other measures of evidence that includes observation and perceiving and thinking. And rely on curated google searches and wikipedia as their research.

Why we are in this forum is to sidestep that illusion, yet many people here still trust google as the final arbiter.

I'm just as glad as you are that we used this forum to confirm each other's experiencing gait ataxia and if I can confirm megadosing b1 is effective, it strengthens our "clinician" equivalent approach to the other "evidence-based' approach. If this forum can do more of this kind of discovery, it would become far more helpful and useful than other forums.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

Elliot Overton counsels clients in nutrition. He has a lot of good videos about thiamine.

Dr. Chandler Marrs treats patients at her clinic.

Dr. Derrick Lonsdale was a pediatrician at the Cleveland Clinic. He's retired now, is over 100 years old, takes TTFD daily, and still responds to questions in the Comments (below the articles) at hormonesmatter.com.

Dr. Costantini (died 2020), treated thousands of Parkinson's Disease patients successfully in Italy with thiamine hcl.

I have to find more time to view/read those links you shared earlier. Thanks a lot!

[yerrag]

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

Hah!! That's a wonderful story! I had cats for many many years; they're wonderful animals. The choices for cat food in the grocery store is just awful. Too much A, too much ash, too much pufa.

I've been taking selenium since last summer. I got blood work done late September and both of my doctors remarked on how much healthier I'd become.

Can you point me to reliable information about iodine? And what's the deal with getting selenium for your iodine intake?

After a few misfires in attempting to provide my cats with food that isn't processed nor pelletized that is so carb heavy, which isn't really suitable, I settled on buying fresh fish in the wet market that is served cooked (without the heavily thyroid-laced head) and sprinkled with supplementation that has their essential protein taurine, among other supplements.. I add shredded coconut meat for its coconut oil content. For dessert they have some scraps of meat from the dinner table I share with them, as well as vegetables I eat, mostly cooked green leaves with coconut milk, or served with a crustacean sauce (which is copper rich. I give them some milk for treats as well. After experiencing a heavy death rate before (unfortunately from my ignorance), my cats are now showing signs of "living long and prospering." The oldest is now 8 years old so I have a lot of time left to see if he can reach 30 years of age and perhaps outlive me.

Selenium acts like an antioxidant in the form of a component of glutathione peroxidase, where its job is to reduce the excess production of hydrogen peroxide used to make T4 in the thyroid and liver and other organs. With a deficiency in selenium, the hydrogen peroxide excess would lead to an excess of T4 as well as tissue destruction. That is how I remember it, although I would rather than you check if my summation is correct here:

https://chrismasterjohnphd.substack.com/p/the-antioxidant-system

CMJ covers a lot here. I am not sure which of the videos cover it, as it has been a long time since I last viewed them.

[yerrag]

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

All very good! Your brain's working well. I suffered from circular thinking for many years. So did my brother; he showed me the condition of his mouth when he was 55; he still had all the amalgam fillings he got as a child. He was desperate to get the circular tick tick tick to turn off. I didn't know how to help him (this was 15 years ago). He committed suicide a few months later.

I'm sorry to see him go that way. Unknown as a casualty of mainstream quack destistry. The ADA, ironically, was born with the seed of mercury amalgamation, and so is tied intimately to mercury and all the while it has denied its toxicity. The dentists against the use of mercury lost out to the ADA because the mercury way was the less painful way, and the effects of mercury do not result in immediate death or sickness, so it was able to hide under the radar.

My dad, come to think of it, was diseased with circular thinking. We was also paranoid, and suffered from both an inferiority complex and a persecution complex. Growing up, it would take forever to have a reasonable argument with him. He would also bring up the past time and again, unrelated as it is to the subject at hand. His influence, unfortunately, was transmitted to most of my sisters, who would have the habit of talking in circles that I eventually avoid having anything to do with them when ever we have to get together and discuss anything. They are pathologically unable to stick to the agenda. But having been subjected to this, I am well aware of it and have long ago vowed, even when I was just ten, not to be like that.

Later on, I felt sorry for my dad instead, as his mind was polluted by mercury, as he had a lot of mercury fillings. I made it a priority to have my mercury fillings in 11 teeth removed. It cost a lot, but thankfully I took advantage of my company's generous health insurance plan to rid myself of it.

[A Former User]

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

banana bags

you mean for thiamine iv infusion?

Yes. There's a good article at that link.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I'm very hopeful that you will be able to fully recover. Or at least achieve tremendous improvement.

I am very confident of this as well.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I had ataxic gait fall of 2020; I kept bouncing off the walls. I also developed a tremor in my right hand. But these resolved via high dose thiamine hcl. When I got so sick, I was taking thiamine hcl, 100mg, 2Xday, but I took it with orange juice (oops). Many of the patient Before Treatment videos show people having a hard time walking, so the Ataxic Gait seems to be a tell tale sign.

I just learned of the term "gait ataxia" or "ataxic gait.." Is this your first time to hear the term as well? Seems like had I know of this term earlier, I would not refer to it as "a symptoms of parkinson's" or "myasthenia gravis." As it would be easier to see it associated with beriberi and to vitamin b1 deficiency.

I learned about "ataxic gait" in 2020 when it was happening to me. Dr. Chandler Marrs has a video where she talks about the deterioration of her mother's health; maybe that's what made me really understand it.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

It seems that all of the thiamine experts that I have relied on are clinicians; they all have had hands on experience treating actual patients rather than only being off in some laboratory working with test tubes and computers. There's tons of good research you can find on line about thiamine, but expensive double blind studies are scarce because no one can patent thiamine.

Very true! This is where the practitioners of "evidence-based" scientism lord it over clinicians all the time. Sad that a majority worship at the temple of scientism. The irony is that the more "educated" one is the more he relies less on other measures of evidence that includes observation and perceiving and thinking. And rely on curated google searches and wikipedia as their research.

I hate Wikipedia; at best it's the consensus of the brainwashed.

The problem with "evidence based" scientism is that the ones in control (medical industrial complex + "science" post Project Paperclip) demand empirical double blind human studies for the "gold standard" of proof. The only entities that can afford to do that type of study are the pharmaceutical companies for things that they can patent to make big bucks on. The system is broken.

Why we are in this forum is to sidestep that illusion, yet many people here still trust google as the final arbiter.

Searching for good studies online is time consuming; the ones they want you to find are at the top; the better ones are buried further down. Using "quotation marks" around key words can shorten the search.

I'm just as glad as you are that we used this forum to confirm each other's experiencing gait ataxia and if I can confirm megadosing b1 is effective, it strengthens our "clinician" equivalent approach to the other "evidence-based' approach. If this forum can do more of this kind of discovery, it would become far more helpful and useful than other forums.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

Elliot Overton counsels clients in nutrition. He has a lot of good videos about thiamine.

Dr. Chandler Marrs treats patients at her clinic.

Dr. Derrick Lonsdale was a pediatrician at the Cleveland Clinic. He's retired now, is over 100 years old, takes TTFD daily, and still responds to questions in the Comments (below the articles) at hormonesmatter.com.

Dr. Costantini (died 2020), treated thousands of Parkinson's Disease patients successfully in Italy with thiamine hcl.

I have to find more time to view/read those links you shared earlier. Thanks a lot!

You're welcome.

There's an enormous amount of information on line about thiamine. It seems modern science cannot keep it hidden so well. For example, if you try to search for Thiamine and Cancer, the first studies that show are the ones about oncologists saying thiamine can cancel out the effect of their chemotherapy drugs so thiamine's bad. But further down the screen, you will find helpful research that includes info about low dose thiamine being carcinogenic but high dose thiamine is anti-carcinogenic. There's also a broad range between the low dose and the high dose that is neither carcinogenic nor anti-carcinogenic.

[pittybitty]

Thiamine supplementation is working well. I have a lot more energy and don't suffer from hypoglycemia anymore. Things keep getting better over time and I am making massive strides in both the gym and on my personal projects. Mood has become more stable as well. Stopped drinking coffee because it no longer seems necessary.

I was skeptical about the dosages at first, but it seems like 2g/day is really appropriate for me. It seems like ludicrous large dose compared to what is used by the body so I wonder how the numbers, absorption rate, etc., add up.

I stopped taking the Niaciamide, it causes me nose congestion and thus bad sleep, which might have been the reason for the emotional confusion at the beginning.

Before what I ate barely had an impact on my energy levels as I just was low energy most of the time. Now I feel hungry a lot more and I notice how much I eat has a big impact on whether I am low or high energy. In a way I feel like I need to relearn my intuition about when to eat what, before the signals were just too noisy to really make any sense.

Thiamine deficiency seems to explain a lot of the energy related issues I had in my life, following roughly this outline:

• Depressed state for 6 months, stop eating carbs because they no longer provide energy.
• Thiamine levels recovered, "Rediscover" carbs, feel great for like a week.
• Low but acceptable thiamine levels for 1-2 months where I can eat "normal" meals and feel mostly okay.
• Thiamine levels are depleted and the cycle restarts.

Many thanks to you @mostlylurking, your suggestion really seems to have resolved the large bane of my youth. I hope I can make the best out of this gift.

So it seems like naturally through nutrition I only get about 1/6th of the thiamine surplus that would be needed for a healthy sugar metabolism.

Occasionally there were also moments were I would get frustrated and over-rely on stress hormones to compensate for the lack of energy, ending up burning out in the process.

I probably had to deal with Thiamine deficiency since I was 7-8 (meaning for like the last 22 years). Back then I changed from a quite energetic extroverted kid to a anxious and depressed introvert. That said I have no idea what could have triggered that, according to my mother there was no change in what food we ate. Heavy metal poisoning like you gals where talking about seems very unlikely. A kind of fungal poisoning might have been possible (my mother has a poverty mindset and thus was very stingy with heating), but also seems improbable, I don't even know if that could cause that kind of symptoms.

Since there is no particular environmental causes I can point to I am considering if it could be genetic, my father has started to have some tremors in his hands, which I understand can be a symptom of a thiamine deficiency, he also isn't the most energetic guy.

Third option, but that might be pure wishful thinking, is just a predisposition to activities that use up a lot of Thiamine, meaning I just need a lot more than the average guy.

[A Former User]

@API-Beast said in Just found out I have reactive hypoglycemia. What now?:

Thiamine supplementation is working well. I have a lot more energy and don't suffer from hypoglycemia anymore. Things keep getting better over time and I am making massive strides in both the gym and on my personal projects. Mood has become more stable as well. Stopped drinking coffee because it no longer seems necessary.

I take it you are using thiamine hcl, 2 grams/day? I don't drink coffee anymore either. It blocks thiamine function (somehow). It's great you are seeing noticeable improvements!

I was skeptical about the dosages at first, but it seems like 2g/day is really appropriate for me. It seems like ludicrous large dose compared to what is used by the body so I wonder how the numbers, absorption rate, etc., add up.

I stopped taking the Niaciamide, it causes me nose congestion and thus bad sleep, which might have been the reason for the emotional confusion at the beginning.

Niacinamide is one of the supplements that Elliot Overton advises to take when high dosing thiamine. I take 100mg of niacinamide 4Xday. Elliot also recommends taking some riboflavin; I also take 100mg of riboflavin, 4Xday. Magnesium is very important because high dose thiamine will use up more magnesium. I take 3100mg of magnesium glycinate/day, divided into two doses; this equals to 400mg of magnesium.

Before what I ate barely had an impact on my energy levels as I just was low energy most of the time. Now I feel hungry a lot more and I notice how much I eat has a big impact on whether I am low or high energy. In a way I feel like I need to relearn my intuition about when to eat what, before the signals were just too noisy to really make any sense.

It is helpful to eat a diet rich in nutrients, including enough protein. Dr. Costantini's FAQs include practical advice.

Thiamine deficiency seems to explain a lot of the energy related issues I had in my life, following roughly this outline:

• Depressed state for 6 months, stop eating carbs because they no longer provide energy.
• Thiamine levels recovered, "Rediscover" carbs, feel great for like a week.
• Low but acceptable thiamine levels for 1-2 months where I can eat "normal" meals and feel mostly okay.
• Thiamine levels are depleted and the cycle restarts.

It is important to have your carb/sugars intake in balance with your available thiamine and your body's needs. Some people simply need more thiamine than others. Elliot Overton's video here explains.

Many thanks to you @mostlylurking, your suggestion really seems to have resolved the large bane of my youth. I hope I can make the best out of this gift.

I think it would be helpful to you to learn more about thiamine so you better understand what's happening and how thiamine is helping you.

Elliot Overton's videos about thiamine are very good.
I also found Dr. Lonsdale's articles very helpful.

So it seems like naturally through nutrition I only get about 1/6th of the thiamine surplus that would be needed for a healthy sugar metabolism.

You lost me.

I think what is important is for your thiamine availability to be in sync with your carbohydrate intake. If you consume too many carbs it will result in a thiamine deficiency and can cause problems. If you are a person who needs more thiamine than average, this will change the equation. Some people need higher doses of thiamine than others. There's a lot of variability.

Occasionally there were also moments were I would get frustrated and over-rely on stress hormones to compensate for the lack of energy, ending up burning out in the process.

Stress depletes thiamine; thiamine is needed to deal with oxidative stress. Information on stress and thiamine:
https://www.sciencedirect.com/science/article/abs/pii/S0197018613000120
https://www.sciencedirect.com/science/article/abs/pii/S0197018601001206?via%3Dihub

I probably had to deal with Thiamine deficiency since I was 7-8 (meaning for like the last 22 years). Back then I changed from a quite energetic extroverted kid to a anxious and depressed introvert. That said I have no idea what could have triggered that, according to my mother there was no change in what food we ate. Heavy metal poisoning like you gals where talking about seems very unlikely. A kind of fungal poisoning might have been possible (my mother has a poverty mindset and thus was very stingy with heating), but also seems improbable, I don't even know if that could cause that kind of symptoms.

Sources for mercury poisoning

Since there is no particular environmental causes I can point to I am considering if it could be genetic, my father has started to have some tremors in his hands, which I understand can be a symptom of a thiamine deficiency, he also isn't the most energetic guy.

Dr. Costantini treated thousands of Parkinson's Disease patients successfully with high dose thiamine. If the hand tremors are treated quickly enough, high dose thiamine can resolve them, but not always.

Dr. Costantini's patients' before and after treatment videos

Third option, but that might be pure wishful thinking, is just a predisposition to activities that use up a lot of Thiamine, meaning I just need a lot more than the average guy.

Yes, that's a possibility.

[pittybitty]

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I take it you are using thiamine hcl, 2 grams/day? I don't drink coffee anymore either. It blocks thiamine function (somehow). It's great you are seeing noticeable improvements!

Yes, exactly.

So it seems like naturally through nutrition I only get about 1/6th of the thiamine surplus that would be needed for a healthy sugar metabolism.

You lost me.

I just mean that it takes about 6 months of very low carb eating to build up enough Thiamine reserves to sustain about 1 month of mixed, normal eating. A ratio of 1/6. Just adjusting carbs to thiamine levels is not feasible as that just results in said long depressive period.

By surplus I mean whatever ingested amount is above what is required daily to sustain the basic function, without eating any extra carbs beyond that, but the math isn't super important.

I think what is important is for your thiamine availability to be in sync with your carbohydrate intake. If you consume too many carbs it will result in a thiamine deficiency and can cause problems. If you are a person who needs more thiamine than average, this will change the equation. Some people need higher doses of thiamine than others. There's a lot of variability.

Occasionally there were also moments were I would get frustrated and over-rely on stress hormones to compensate for the lack of energy, ending up burning out in the process.

Stress depletes thiamine; thiamine is needed to deal with oxidative stress. Information on stress and thiamine:

Yes I read that from your conversations with yerrag. Those stressful periods were quite unpleasant and ineffective.

[A Former User]

@API-Beast said in Just found out I have reactive hypoglycemia. What now?:

I just mean that it takes about 6 months of very low carb eating to build up enough Thiamine reserves to sustain about 1 month of mixed, normal eating. A ratio of 1/6. Just adjusting carbs to thiamine levels is not feasible as that just results in said long depressive period.

By surplus I mean whatever ingested amount is above what is required daily to sustain the basic function, without eating any extra carbs beyond that, but the math isn't super important.

I'm sorry but what you are saying doesn't make sense.
https://www.healthline.com/nutrition/thiamine-deficiency-symptoms#basics
"Like the other B vitamins, thiamine is water-soluble. That means that it dissolves in water and isn’t stored in your body, so you need to consume it on a regular basis. In fact, your body can only store around 20 days’ worth of thiamine at any given time (2Trusted Source)."

[yerrag]

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

banana bags

you mean for thiamine iv infusion?

Yes. There's a good article at that link.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I'm very hopeful that you will be able to fully recover. Or at least achieve tremendous improvement.

I am very confident of this as well.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I had ataxic gait fall of 2020; I kept bouncing off the walls. I also developed a tremor in my right hand. But these resolved via high dose thiamine hcl. When I got so sick, I was taking thiamine hcl, 100mg, 2Xday, but I took it with orange juice (oops). Many of the patient Before Treatment videos show people having a hard time walking, so the Ataxic Gait seems to be a tell tale sign.

I just learned of the term "gait ataxia" or "ataxic gait.." Is this your first time to hear the term as well? Seems like had I know of this term earlier, I would not refer to it as "a symptoms of parkinson's" or "myasthenia gravis." As it would be easier to see it associated with beriberi and to vitamin b1 deficiency.

I learned about "ataxic gait" in 2020 when it was happening to me. Dr. Chandler Marrs has a video where she talks about the deterioration of her mother's health; maybe that's what made me really understand it.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

It seems that all of the thiamine experts that I have relied on are clinicians; they all have had hands on experience treating actual patients rather than only being off in some laboratory working with test tubes and computers. There's tons of good research you can find on line about thiamine, but expensive double blind studies are scarce because no one can patent thiamine.

Very true! This is where the practitioners of "evidence-based" scientism lord it over clinicians all the time. Sad that a majority worship at the temple of scientism. The irony is that the more "educated" one is the more he relies less on other measures of evidence that includes observation and perceiving and thinking. And rely on curated google searches and wikipedia as their research.

I hate Wikipedia; at best it's the consensus of the brainwashed.

The problem with "evidence based" scientism is that the ones in control (medical industrial complex + "science" post Project Paperclip) demand empirical double blind human studies for the "gold standard" of proof. The only entities that can afford to do that type of study are the pharmaceutical companies for things that they can patent to make big bucks on. The system is broken.

Why we are in this forum is to sidestep that illusion, yet many people here still trust google as the final arbiter.

Searching for good studies online is time consuming; the ones they want you to find are at the top; the better ones are buried further down. Using "quotation marks" around key words can shorten the search.

I'm just as glad as you are that we used this forum to confirm each other's experiencing gait ataxia and if I can confirm megadosing b1 is effective, it strengthens our "clinician" equivalent approach to the other "evidence-based' approach. If this forum can do more of this kind of discovery, it would become far more helpful and useful than other forums.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

Elliot Overton counsels clients in nutrition. He has a lot of good videos about thiamine.

Dr. Chandler Marrs treats patients at her clinic.

Dr. Derrick Lonsdale was a pediatrician at the Cleveland Clinic. He's retired now, is over 100 years old, takes TTFD daily, and still responds to questions in the Comments (below the articles) at hormonesmatter.com.

Dr. Costantini (died 2020), treated thousands of Parkinson's Disease patients successfully in Italy with thiamine hcl.

I have to find more time to view/read those links you shared earlier. Thanks a lot!

You're welcome.

There's an enormous amount of information on line about thiamine. It seems modern science cannot keep it hidden so well. For example, if you try to search for Thiamine and Cancer, the first studies that show are the ones about oncologists saying thiamine can cancel out the effect of their chemotherapy drugs so thiamine's bad. But further down the screen, you will find helpful research that includes info about low dose thiamine being carcinogenic but high dose thiamine is anti-carcinogenic. There's also a broad range between the low dose and the high dose that is neither carcinogenic nor anti-carcinogenic.

What serendipity, CMJ has an article on hi-dose supplementation on what to look out for in implementing hi-dose b1 supplementation. It's free for a day on substack. I wonder what's the best way to save it for my use. Perhaps print to PDF;

https://open.substack.com/pub/chrismasterjohnphd/p/thiamin-supplements-not-for-everyone?utm_campaign=post&utm_medium=email

BTW, On the third day of 1500mg b1, I saw my overnight O²Ring chart go from a score of 7.5 to 9.3, indicating lower frequency in spO2 drops, and lower levels of drops in magnitude, which had been ongoing as far back as 3 years ago, when I began tracking it.

I also saw my ECG's QRS curve increase in height signifying strong electrical voltage restored in pumping my heart, which I track to ascertain how much free my lungs was free from liquid (pleural effusion). My QTc value , a proxy marker for testing for hypothyroidism Ray has talked about, has improved from 440 msec to 385, pushing me towards hyper to normo-thyroid territory.

Still waiting for my gait ataxia to disappear.

[pittybitty]

@mostlylurking oh okay, then I need to find a different explanation for the waning levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659035/ says it's stored for up to 18 days which is obviously a much smaller time period than I described.

[A Former User]

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

banana bags

you mean for thiamine iv infusion?

Yes. There's a good article at that link.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I'm very hopeful that you will be able to fully recover. Or at least achieve tremendous improvement.

I am very confident of this as well.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I had ataxic gait fall of 2020; I kept bouncing off the walls. I also developed a tremor in my right hand. But these resolved via high dose thiamine hcl. When I got so sick, I was taking thiamine hcl, 100mg, 2Xday, but I took it with orange juice (oops). Many of the patient Before Treatment videos show people having a hard time walking, so the Ataxic Gait seems to be a tell tale sign.

I just learned of the term "gait ataxia" or "ataxic gait.." Is this your first time to hear the term as well? Seems like had I know of this term earlier, I would not refer to it as "a symptoms of parkinson's" or "myasthenia gravis." As it would be easier to see it associated with beriberi and to vitamin b1 deficiency.

I learned about "ataxic gait" in 2020 when it was happening to me. Dr. Chandler Marrs has a video where she talks about the deterioration of her mother's health; maybe that's what made me really understand it.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

It seems that all of the thiamine experts that I have relied on are clinicians; they all have had hands on experience treating actual patients rather than only being off in some laboratory working with test tubes and computers. There's tons of good research you can find on line about thiamine, but expensive double blind studies are scarce because no one can patent thiamine.

Very true! This is where the practitioners of "evidence-based" scientism lord it over clinicians all the time. Sad that a majority worship at the temple of scientism. The irony is that the more "educated" one is the more he relies less on other measures of evidence that includes observation and perceiving and thinking. And rely on curated google searches and wikipedia as their research.

I hate Wikipedia; at best it's the consensus of the brainwashed.

The problem with "evidence based" scientism is that the ones in control (medical industrial complex + "science" post Project Paperclip) demand empirical double blind human studies for the "gold standard" of proof. The only entities that can afford to do that type of study are the pharmaceutical companies for things that they can patent to make big bucks on. The system is broken.

Why we are in this forum is to sidestep that illusion, yet many people here still trust google as the final arbiter.

Searching for good studies online is time consuming; the ones they want you to find are at the top; the better ones are buried further down. Using "quotation marks" around key words can shorten the search.

I'm just as glad as you are that we used this forum to confirm each other's experiencing gait ataxia and if I can confirm megadosing b1 is effective, it strengthens our "clinician" equivalent approach to the other "evidence-based' approach. If this forum can do more of this kind of discovery, it would become far more helpful and useful than other forums.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

Elliot Overton counsels clients in nutrition. He has a lot of good videos about thiamine.

Dr. Chandler Marrs treats patients at her clinic.

Dr. Derrick Lonsdale was a pediatrician at the Cleveland Clinic. He's retired now, is over 100 years old, takes TTFD daily, and still responds to questions in the Comments (below the articles) at hormonesmatter.com.

Dr. Costantini (died 2020), treated thousands of Parkinson's Disease patients successfully in Italy with thiamine hcl.

I have to find more time to view/read those links you shared earlier. Thanks a lot!

You're welcome.

There's an enormous amount of information on line about thiamine. It seems modern science cannot keep it hidden so well. For example, if you try to search for Thiamine and Cancer, the first studies that show are the ones about oncologists saying thiamine can cancel out the effect of their chemotherapy drugs so thiamine's bad. But further down the screen, you will find helpful research that includes info about low dose thiamine being carcinogenic but high dose thiamine is anti-carcinogenic. There's also a broad range between the low dose and the high dose that is neither carcinogenic nor anti-carcinogenic.

What serendipity, CMJ has an article on hi-dose supplementation on what to look out for in implementing hi-dose b1 supplementation. It's free for a day on substack. I wonder what's the best way to save it for my use. Perhaps print to PDF;

I went over to CMJ's site and read his article. There's quite a bit in it that made me scratch my head in wonder/confusion.

It seems to me that CMJ is confusing reactions to TTFD as being reactions to thiamine in general, which is simply not the case. For example, CMJ says in the article:

"Excessive thiamine supplementation would not be expected to directly interfere with the absorption of other nutrients, but it could puts stress on four metabolic pathways that either creates an imbalance with other nutrients or worsens a genetic impairment, and it probably generates sulfite within the human body. Sulfite is toxic, accelerates glutamate excitation of and damage to nerves, can degranulate mast cells and cause pseudo-allergies, and the process of generating and detoxifying sulfite puts stress on the requirements for coenzyme Q10, glutathione, molybdenum, and copper."

Right off the bat, I glommed onto "puts stress on the requirements for...gluathione.... TTFD uses glutathione, whereas thiamine hcl does not. In fact, by massively reducing my level of oxidative stress, taking high dose thiamine hcl allowed my low glutathione level to rise to the "normal" range which was proven via blood testing. My glutathione level had been in the ditch for decades.

Also, I've been intensely sensitive to sulfites for many years; I have not had any negative reaction to thiamine hcl. It is my understanding that thiamine hcl includes a sulfur component that mercury is attracted to. "Sulfur" does not equal "sulfite"; your body needs sulfur.

Distinction Between Sulfide and Sulfite There's a short video included about sulfites.

It makes sense that if you improve your body's function in a meaningful way, whether it's by thyroid supplementation or by thiamine supplementation, other nutrients/vitamins/minerals will get used more and possibly result in new deficiencies. Please note that it is known that high dosing thiamine will cause the body to use up more magnesium and potassium and will probably cause the body to need more niacin and riboflavin. I take 3100mg magnesium glycinate (=400mg magnesium) per day, 100mg niacinamide, 4Xday, and 100mg riboflavin, 4Xday; I rely on drinking orange juice for my potassium. I also experienced a problem with my electrolyte balance after high dosing thiamine hcl for several weeks; I recovered when I increased my salt intake.

https://open.substack.com/pub/chrismasterjohnphd/p/thiamin-supplements-not-for-everyone?utm_campaign=post&utm_medium=email

BTW, On the third day of 1500mg b1, I saw my overnight O²Ring chart go from a score of 7.5 to 9.3, indicating lower frequency in spO2 drops, and lower levels of drops in magnitude, which had been ongoing as far back as 3 years ago, when I began tracking it.

That's a good thing, right?

I also saw my ECG's QRS curve increase in height signifying strong electrical voltage restored in pumping my heart, which I track to ascertain how much free my lungs was free from liquid (pleural effusion). My QTc value , a proxy marker for testing for hypothyroidism Ray has talked about, has improved from 440 msec to 385, pushing me towards hyper to normo-thyroid territory.

The stronger electrical voltage restoring your heart's ability to pump is good news, yes?

I also experienced improvement in my thyroid function when I began high dosing thiamine hcl. The thyroid, like every other part of the body, needs thiamine to make ATP so it can do its job. I got into a little trouble with my T3 getting out of range on the high side so my endocrinologist lowered my prescription desiccated thyroid medication. He explained to me that I had become "hyperthyroid" and hyperthyroidism causes thiamine deficiency. I recovered quickly and my thyroid med and my thiamine hcl supplementation are working well together now.

Still waiting for my gait ataxia to disappear.

Everybody is different. Different symptoms will take longer to resolve than others. I experienced noticeable improvements over a period of 6 months. Then noticeable improvements leveled off/stabilized.

[A Former User]

@API-Beast said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking oh okay, then I need to find a different explanation for the waning levels.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3659035/ says it's stored for up to 18 days which is obviously a much smaller time period than I described.

Which "waning levels"? Are you noticing the return of symptoms while still supplementing with a consistent amount of thiamine? Or is your thiamine supplementation not consistent?

[A Former User]

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

@yerrag said in Just found out I have reactive hypoglycemia. What now?:

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

banana bags

you mean for thiamine iv infusion?

Yes. There's a good article at that link.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I'm very hopeful that you will be able to fully recover. Or at least achieve tremendous improvement.

I am very confident of this as well.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

I had ataxic gait fall of 2020; I kept bouncing off the walls. I also developed a tremor in my right hand. But these resolved via high dose thiamine hcl. When I got so sick, I was taking thiamine hcl, 100mg, 2Xday, but I took it with orange juice (oops). Many of the patient Before Treatment videos show people having a hard time walking, so the Ataxic Gait seems to be a tell tale sign.

I just learned of the term "gait ataxia" or "ataxic gait.." Is this your first time to hear the term as well? Seems like had I know of this term earlier, I would not refer to it as "a symptoms of parkinson's" or "myasthenia gravis." As it would be easier to see it associated with beriberi and to vitamin b1 deficiency.

I learned about "ataxic gait" in 2020 when it was happening to me. Dr. Chandler Marrs has a video where she talks about the deterioration of her mother's health; maybe that's what made me really understand it.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

It seems that all of the thiamine experts that I have relied on are clinicians; they all have had hands on experience treating actual patients rather than only being off in some laboratory working with test tubes and computers. There's tons of good research you can find on line about thiamine, but expensive double blind studies are scarce because no one can patent thiamine.

Very true! This is where the practitioners of "evidence-based" scientism lord it over clinicians all the time. Sad that a majority worship at the temple of scientism. The irony is that the more "educated" one is the more he relies less on other measures of evidence that includes observation and perceiving and thinking. And rely on curated google searches and wikipedia as their research.

I hate Wikipedia; at best it's the consensus of the brainwashed.

The problem with "evidence based" scientism is that the ones in control (medical industrial complex + "science" post Project Paperclip) demand empirical double blind human studies for the "gold standard" of proof. The only entities that can afford to do that type of study are the pharmaceutical companies for things that they can patent to make big bucks on. The system is broken.

Why we are in this forum is to sidestep that illusion, yet many people here still trust google as the final arbiter.

Searching for good studies online is time consuming; the ones they want you to find are at the top; the better ones are buried further down. Using "quotation marks" around key words can shorten the search.

I'm just as glad as you are that we used this forum to confirm each other's experiencing gait ataxia and if I can confirm megadosing b1 is effective, it strengthens our "clinician" equivalent approach to the other "evidence-based' approach. If this forum can do more of this kind of discovery, it would become far more helpful and useful than other forums.

@mostlylurking said in Just found out I have reactive hypoglycemia. What now?:

Elliot Overton counsels clients in nutrition. He has a lot of good videos about thiamine.

Dr. Chandler Marrs treats patients at her clinic.

Dr. Derrick Lonsdale was a pediatrician at the Cleveland Clinic. He's retired now, is over 100 years old, takes TTFD daily, and still responds to questions in the Comments (below the articles) at hormonesmatter.com.

Dr. Costantini (died 2020), treated thousands of Parkinson's Disease patients successfully in Italy with thiamine hcl.

I have to find more time to view/read those links you shared earlier. Thanks a lot!

You're welcome.

There's an enormous amount of information on line about thiamine. It seems modern science cannot keep it hidden so well. For example, if you try to search for Thiamine and Cancer, the first studies that show are the ones about oncologists saying thiamine can cancel out the effect of their chemotherapy drugs so thiamine's bad. But further down the screen, you will find helpful research that includes info about low dose thiamine being carcinogenic but high dose thiamine is anti-carcinogenic. There's also a broad range between the low dose and the high dose that is neither carcinogenic nor anti-carcinogenic.

What serendipity, CMJ has an article on hi-dose supplementation on what to look out for in implementing hi-dose b1 supplementation. It's free for a day on substack. I wonder what's the best way to save it for my use. Perhaps print to PDF;

https://open.substack.com/pub/chrismasterjohnphd/p/thiamin-supplements-not-for-everyone?utm_campaign=post&utm_medium=email

BTW, On the third day of 1500mg b1, I saw my overnight O²Ring chart go from a score of 7.5 to 9.3, indicating lower frequency in spO2 drops, and lower levels of drops in magnitude, which had been ongoing as far back as 3 years ago, when I began tracking it.

I also saw my ECG's QRS curve increase in height signifying strong electrical voltage restored in pumping my heart, which I track to ascertain how much free my lungs was free from liquid (pleural effusion). My QTc value , a proxy marker for testing for hypothyroidism Ray has talked about, has improved from 440 msec to 385, pushing me towards hyper to normo-thyroid territory.

Still waiting for my gait ataxia to disappear.

More about the CMJ's article about thiamine:
He writes:
"Dr. Derrick Lonsdale writes in the book he authored with Chandler Marrs, Thiamine Deficiency Disease, Dysautonomia, and High-Calorie Malnutrition that every case he saw of a “paradoxical” reaction to thiamin was self-resolving, with benefit arising after the initial hump of difficulty. My experience from a different and broader context suggests that there are many people who get adverse reactions that do not end until thiamin supplementation is stopped rather than these self-resolving paradoxical reactions."

Please note that "paradoxical reactions" to thiamine discussed by Dr. Lonsdale are specifically about TTFD thiamine. In contrast, Dr. Costantini, who used thiamine hcl exclusively for treating his patients said that there should be NO negative reactions to taking thiamine hcl. He did say that rarely a patient would experience a negative reaction to it; his solution was to stop the thiamine for a week, then invite the patient to resume the treatment at half the dose.

Dr. Costantini's Therapy info

Please note that TTFD thiamine is a synthetic newer version of thiamine that does have some advantages. It is easily absorbed in the gut so the size of the dose is much smaller than the oral dose needed for thiamine hcl. TTFD is also supposed to "get into the cell" much easier than thiamine hcl which may be an advantage for some people with genetic variations that make thiamine absorption on the cellular level less effective/blocked. TTFD doesn't have the "transport" issues that thiamine hcl might have for some people? Lonsdale, Marrs, and Overton know a lot more about TTFD than I do and all three seem to prefer recommending TTFD. Elliot Overton is affiliated with the company that makes Thiamax TTFD. He has stated that if you find a type of thiamine that works well for you that you should stick with that type.