is it fine that cyproheptadine and ondanestron increase serotonin in certain brain areas?
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ive been having frequent nasuea symptoms particularly spurring at morning/exercise. usually wake up dehydrated too dry mouth and yellow piss, white coating on tongue i can brush it ll off but it comes next day. i only brush ince a day in morning.
ive been prescribed ondanestron, but i could ask doc to consider cyproheptadine as well? are there implications taking this long term? like if i come off i could get nasuea returning even worse?
i have very low appetite as well, sometimes eat just 1 meal a day at night another reason desiring cypro
where i got this question from after chatgpt:
ondansetron can indirectly increase serotonin levels in certain parts of the brain by blocking the serotonin 5-HT3 receptors. Serotonin (5-HT) is a neurotransmitter involved in various physiological processes, including mood regulation, nausea and vomiting, appetite, and sleep.When serotonin is released into the synaptic cleft (the gap between nerve cells), it activates various serotonin receptors on the postsynaptic neuron. One subtype of serotonin receptor is the 5-HT3 receptor, which is located in the central nervous system, particularly in the area postrema of the brainstem. Activation of these receptors can trigger nausea and vomiting.
Ondansetron is a selective antagonist of the serotonin 5-HT3 receptors. By blocking these receptors, ondansetron prevents the actions of serotonin on these receptors, thereby reducing nausea and vomiting. This blockade indirectly increases serotonin levels in certain regions of the brain by preventing its removal from the synapse and subsequent reuptake. However, it's important to note that ondansetron's primary action is to block 5-HT3 receptors rather than directly increasing serotonin release.
So, while ondansetron can indirectly affect serotonin levels in the brain, its mechanism of action is distinct from that of medications like SSRIs, which directly increase serotonin levels by inhibiting its reuptake.
cyproheptadine is known to increase serotonin levels in the brain. Cyproheptadine is a first-generation antihistamine that also possesses antiserotonergic properties. One of its mechanisms of action is to block serotonin receptors, particularly the 5-HT2A receptor subtype. By blocking these receptors, cyproheptadine prevents the actions of serotonin at these sites.
However, the precise mechanism by which cyproheptadine increases serotonin levels is not fully understood. It's possible that by blocking serotonin receptors, cyproheptadine may indirectly lead to increased serotonin release in certain brain regions. Additionally, cyproheptadine may also inhibit the reuptake of serotonin, further contributing to elevated serotonin levels.
Cyproheptadine is sometimes used off-label in the treatment of conditions associated with serotonin deficiency or dysregulation, such as serotonin syndrome, certain types of headaches, and appetite stimulation in underweight individuals. However, its use for these purposes is not as common as other medications that directly modulate serotonin levels, such as selective serotonin reuptake inhibitors (SSRIs).
As with any medication, it's important to use cyproheptadine under the guidance of a healthcare professional to ensure safe and effective treatment. Additionally, potential side effects and drug interactions should be carefully considered before starting cyproheptadine therapy.
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the nausea is probablbly form looking at the mirror
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@peatyourmeat keep copintg The MOUSE mogs.
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@thyroidchor27 you are right, i was thinking of @Ecstatic_Hamster
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A more effective and elegant way to lower serotonin is through the endocannabinoid system.
There is a retrograde process where endocannabinoids suppress serotonin for reals.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766225/
In the present study, using whole-cell recording from DR 5-HT neurons, we examined the effects of eCBs on glutamatergic synapses in the DR.
We found that the eCB anandamide decreased the amplitude of evoked excitatory postsynaptic currents (eEPSCs). This effect was blocked by CB1 receptor antagonist N-(piperidin-1-yl)-5-(4-iodophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM 251) and mimicked by (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate (WIN 55,212-2), a CB1 receptor agonist.
The inhibition of eEPSC amplitude was associated with an increase in the paired-pulse ratio and coefficient of variance. Activation of CB1 receptors also reduced the frequency, but not the amplitude, of miniature excitatory postsynaptic currents, indicating that eCBs inhibit glutamate release in the DR. I
n addition, we found that depolarization of DR 5-HT neurons induced a transient inhibition of the amplitude of eEPSCs, termed depolarization-induced suppression of excitation (DSE).
The induction of DSE required an increase in postsynaptic intracellular calcium and was due to a decrease in glutamate release. Furthermore, pharmacological studies showed that blockade of CB1 receptors with AM 251 abolished the DSE. In contrast, activation of CB1 receptors with WIN 55,212-2 mimicked and occluded the DSE, indicating that depolarization of DR 5-HT neurons triggers eCB release, which in turn mediates the DSE. Together, these results indicate that eCBs play a role in modulating glutamatergic synaptic transmission to DR 5-HT neurons
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@Ecstatic_Hamster said in is it fine that cyproheptadine and ondanestron increase serotonin in certain brain areas?:
anandamide
Hey Ecstatic, do you have a source for anandamide?
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@BronzeAgePater cannabis
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@Ecstatic_Hamster whats the best CBD to THC ratio and is it ideal when you dont notiecably get high (So that the CBD is outweighing the THC in the body ie)
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@Ecstatic_Hamster thanks
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@thyroidchor27 depends on how you take it and the type.
If you put potent THC into cocoa butter and use it rectally you won't get high even with huge amounts of THC.
Raw THCA is the THC precursor that is not heated up and it doesn't make you high either.
CBD can stop the psychoactive properties of THC to a great degree also, maybe a high amount of CBD and relatively small amounts of THC.
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@Ecstatic_Hamster thank you for response. im too low iq to comprehend it tho ngl, so i just smoke cannabis?
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@Ecstatic_Hamster I read somewhere that cannabis increases AA and 2AG by inhibiting their breakdown. This would be counterproductive ?
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@thyroidchor27 why woudl that be counter productive exactly?
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@Ecstatic_Hamster https://www.researchgate.net/publication/274260637_Elevation_of_Plasma_2-Arachidonoylglycerol_Levels_in_Alzheimer's_Disease_Patients_as_a_Potential_Protective_Mechanism_against_Neurodegenerative_Decline
Haven’t gone deep but it seems it rises as a preventative mechanism for further damage but I’m not convinced. It’s maybe an inferior backup like adrenals when thyroid goes? Need to do more research. Know any good book on the cannabinoid sys and how cannabis influences it?
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@thyroidchor27 said in is it fine that cyproheptadine and ondanestron increase serotonin in certain brain areas?:
@Ecstatic_Hamster https://www.researchgate.net/publication/274260637_Elevation_of_Plasma_2-Arachidonoylglycerol_Levels_in_Alzheimer's_Disease_Patients_as_a_Potential_Protective_Mechanism_against_Neurodegenerative_Decline
Haven’t gone deep but it seems it rises as a preventative mechanism for further damage but I’m not convinced. It’s maybe an inferior backup like adrenals when thyroid goes? Need to do more research. Know any good book on the cannabinoid sys and how cannabis influences it?
I don't know of any good book on it. Dr. Michael Moskowitz' book is good but it's maybe 6 years old.
There seems to be evidence that CBD can increase neurogenesis.
I think these pathways are incredibly powerful. I think Georgi told me he feels that CBD or THC may lower serotonin independently through the HT1 receptor, which suppresses serotonin.
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@Ecstatic_Hamster Is a 2:1 cbd to thc ratio oil good if taken in just the right amount that a perceptible THC induced dysfunction in thinking isnt noticed?
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@thyroidchor27 probably. Some ratios of 10:1 or 30:1 CBD:THC may even be better for most health issues.
