Idealabs Supplements Review
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@alfredoolivas yeah, well, Wikipedia might be fake news here
https://lowtoxinforum.com/threads/the-anti-cortisol-mechanism-of-progesterone.14590/
"...Cortisol binds both the glucocorticoid receptor and the mineralo corticoid receptor; progesterone binds both the progesterone receptor and the glucocorticoid receptor, for which it is an antagonist."
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@engineer If it were anti cortisol, we would see reductions in amino transferases such as ALT, AALP and GGT. They don't and may even increase it.
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@alfredoolivas so is Haidut's referenced study bogus?
another one:
https://www.lowtoxinforum.com/threads/the-anabolic-effects-of-progesterone.16381/
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@engineer It certainly isn't 85% as anabolic as methyltestosterone. Perhaps rodents convert progesterone into androgens via the backdoor pathway more than human
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@alfredoolivas does this have implications for 6-keto? If so, are there any other good GR antagonists comparable in safety to prog/6kprog?
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@engineer most steroids are really shitty at blocking the GR. Even trenbolone is a poor functional antagonist. Androgens exhibit their anti glucocorticoid effects by blocking the transport of the GR receptor to the nucleous.
Methyltrenbolone has the highest affinity iirc. It has such a long half life that it will constantly block it's receptor against the nanogram amounts of cortisol being produced every second.
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@alfredoolivas the big problem with all the trenbolone family members is the nasty secondary effects
https://lowtoxinforum.com/threads/trenbolone-experiences-log.37957
It sounds so good to have that much cortisol blocking but it otherwise isn't Peaty
Or is methyl tren different?
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@alfredoolivas hold on, since DHT is highly androgenic, doesnt that mean it would be anabolic as well? 11-keto is more resistant to metabolism so maybe it has a significant effect here? It appears as though 12 drops per day of 11-keto-DHT would cost the same as 25 drops of 6-keto-p4.
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Meldonium is wayyyyy better than pyrucet
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@heyman said in Idealabs Supplements Review:
Meldonium is wayyyyy better than pyrucet
what has Ray Peat said about it?
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@engineer It gets deactivated in muscle tissue. Even methylated DHT, mestanalone, which is resistant to metabolism, was classed as androgenic and not very anabolic
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@alfredoolivas now, even though it isn't directly anabolic, could it assist in achieving that goal by lowering cortisol and prolactin?
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@engineer I think prolactin is anabolic, if i remember correctly. It probably lowers cortisol via reduced AcTH
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@alfredoolivas cite some studies
I can't find anything saying prolactin is positive in anything but thymus regeneration and dopamine suppression/serotonin production
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@engineer I just knows it rises along with growth hormone
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@engineer Hypoprolactenmia, which can be achieved easily via caber use etc, is really bad though.
