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    Idealabs Supplements Review

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    • alfredoolivasA Offline
      alfredoolivas @engineer
      last edited by

      @engineer If it were anti cortisol, we would see reductions in amino transferases such as ALT, AALP and GGT. They don't and may even increase it.

      engineerE 1 Reply Last reply Reply Quote 0
      • engineerE Offline
        engineer @alfredoolivas
        last edited by engineer

        @alfredoolivas so is Haidut's referenced study bogus?

        another one:

        https://www.lowtoxinforum.com/threads/the-anabolic-effects-of-progesterone.16381/

        alfredoolivasA 1 Reply Last reply Reply Quote 0
        • alfredoolivasA Offline
          alfredoolivas @engineer
          last edited by

          @engineer It certainly isn't 85% as anabolic as methyltestosterone. Perhaps rodents convert progesterone into androgens via the backdoor pathway more than human

          engineerE 1 Reply Last reply Reply Quote 0
          • engineerE Offline
            engineer @alfredoolivas
            last edited by

            @alfredoolivas does this have implications for 6-keto? If so, are there any other good GR antagonists comparable in safety to prog/6kprog?

            alfredoolivasA 1 Reply Last reply Reply Quote 1
            • alfredoolivasA Offline
              alfredoolivas @engineer
              last edited by alfredoolivas

              @engineer most steroids are really shitty at blocking the GR. Even trenbolone is a poor functional antagonist. Androgens exhibit their anti glucocorticoid effects by blocking the transport of the GR receptor to the nucleous.

              Methyltrenbolone has the highest affinity iirc. It has such a long half life that it will constantly block it's receptor against the nanogram amounts of cortisol being produced every second.

              engineerE 2 Replies Last reply Reply Quote 2
              • engineerE Offline
                engineer @alfredoolivas
                last edited by engineer

                @alfredoolivas the big problem with all the trenbolone family members is the nasty secondary effects

                https://lowtoxinforum.com/threads/trenbolone-experiences-log.37957

                It sounds so good to have that much cortisol blocking but it otherwise isn't Peaty

                Or is methyl tren different?

                alfredoolivasA 1 Reply Last reply Reply Quote 0
                • engineerE Offline
                  engineer @alfredoolivas
                  last edited by engineer

                  @alfredoolivas hold on, since DHT is highly androgenic, doesnt that mean it would be anabolic as well? 11-keto is more resistant to metabolism so maybe it has a significant effect here? It appears as though 12 drops per day of 11-keto-DHT would cost the same as 25 drops of 6-keto-p4.

                  1 Reply Last reply Reply Quote 0
                  • H Offline
                    heyman
                    last edited by

                    Meldonium is wayyyyy better than pyrucet

                    engineerE 1 Reply Last reply Reply Quote 0
                    • engineerE Offline
                      engineer @heyman
                      last edited by

                      @heyman said in Idealabs Supplements Review:

                      Meldonium is wayyyyy better than pyrucet

                      what has Ray Peat said about it?

                      H 1 Reply Last reply Reply Quote 0
                      • alfredoolivasA Offline
                        alfredoolivas @engineer
                        last edited by

                        @engineer It gets deactivated in muscle tissue. Even methylated DHT, mestanalone, which is resistant to metabolism, was classed as androgenic and not very anabolic

                        engineerE 1 Reply Last reply Reply Quote 0
                        • engineerE Offline
                          engineer @alfredoolivas
                          last edited by

                          @alfredoolivas now, even though it isn't directly anabolic, could it assist in achieving that goal by lowering cortisol and prolactin?

                          https://lowtoxinforum.com/threads/11-keto-dht-adrenosterone-derivative-for-lab-r-d-use.11922/post-164238

                          alfredoolivasA 1 Reply Last reply Reply Quote 0
                          • alfredoolivasA Offline
                            alfredoolivas @engineer
                            last edited by

                            @engineer I think prolactin is anabolic, if i remember correctly. It probably lowers cortisol via reduced AcTH

                            engineerE 1 Reply Last reply Reply Quote 0
                            • engineerE Offline
                              engineer @alfredoolivas
                              last edited by engineer

                              @alfredoolivas cite some studies

                              I can't find anything saying prolactin is positive in anything but thymus regeneration and dopamine suppression/serotonin production

                              https://www.lowtoxinforum.com/threads/prolactin-is-a-good-biomarker-for-serotonin-estrogen-activity.3594/

                              https://x.com/BerbarianWizard/status/2009547543697383455

                              alfredoolivasA 2 Replies Last reply Reply Quote 0
                              • alfredoolivasA Offline
                                alfredoolivas @engineer
                                last edited by

                                @engineer I just knows it rises along with growth hormone

                                1 Reply Last reply Reply Quote 0
                                • alfredoolivasA Offline
                                  alfredoolivas @engineer
                                  last edited by

                                  @engineer Hypoprolactenmia, which can be achieved easily via caber use etc, is really bad though.

                                  1 Reply Last reply Reply Quote 0
                                  • D Offline
                                    DKJoeAgain
                                    last edited by DKJoeAgain

                                    You have been using all of these supplements within the space of 6 weeks? How are you able to accurately differentiate their effects? Not jabbing but could you detail your regimen?

                                    Could you also describe the feeling of sugar burn and carb burn as well please? I took pyrucet for around 2 months and didn't 'feel' much of anything though I did notice effects on body composition etc...

                                    engineerE 1 Reply Last reply Reply Quote 0
                                    • H Offline
                                      heyman @engineer
                                      last edited by

                                      @engineer https://raypeat.com/articles/articles/unsuitablefats.shtml

                                      1 Reply Last reply Reply Quote 0
                                      • engineerE Offline
                                        engineer @DKJoeAgain
                                        last edited by

                                        @DKJoeAgain now that I think about it, it has been more like 2 months, but even so I tend to respond quickly to supplements. Usually, the way I've done it is I add on something, wait several days to feel what the effects are, and assess. The effects seem to plateau after that so that's how I've been able to assess them.

                                        For the pyrucet, the carb burn effect isn't really something you feel but rather something you observe. So although I might have felt a little warmer in the midsection (due to faster digestion of things like orange juice) the end result is that I feel hungrier and hypoglycemic much earlier than if I had not taken the pyrucet. It was shocking how much earlier it was at first but now I've gotten used to it. And you can tell the carbs were burned, because you feel no more bloating than without the pyrucet with the same amount of carbs.

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