Lifespan-Extending Endogenous Metabolites

[DavidPS]

The article below discusses the state of the science for several of the lifespan-extending contenders, including:

• Taurine
• Betaine
• α-Ketoglutarate
• Oxaloacetate
• Hydrogen Sulfide
• Myo-Inositol
• NAD+
• Methionine
• Branched Chain Amino Acids
• Trehalose
• Spermidine
• Lipid-Related Metabolites

Lifespan-Extending Endogenous Metabolites (2025)

[Mauritio]

Interestingly a lot of the benefits of dietary/protein restriction seem to be due to an endogenous increase inH2S synthesis.

https://www.cell.com/fulltext/S0092-8674(14)01525-6?fbclid=IwAR3SjzdrM-ISKhbiY6e2kDEu3eJJAUZgCSkEPZEu59LyOEAR_0PNNcTNs9c

It seems to have some beneficial effects for the ETC.

"H2S can stimulate mitochondrial respiration at sites downstream of common PMD-defective subunits, augmenting energy production, mitochondrial function and reducing cell death. "
https://www.sciencedirect.com/science/article/pii/S1043661824001245

[DavidPS]

@Mauritio said in Lifespan-Extending Endogenous Metabolites:

Interestingly a lot of the benefits of dietary/protein restriction seem to be due to an endogenous increase inH2S synthesis.

I am wondering if the endogenous increase is a compensatory mechanism for the lower protein.

Impact of diet on hydrogen sulfide production: implications for gut health (2023)