D-chiro inhibits aromatase,ups androgens and dhea,mimics insulin,raises glucose oxidation
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Increased Androgens: A pilot study on male volunteers (1 g/day for 1 month) found that DCI administration was associated with a +23.4% increase in testosterone and a +13.8% increase in dehydroepiandrosterone (DHEA).
Reduced Estrogens: In the same study, DCI significantly reduced estrone levels (-85.0%) and reduced estradiol levels (-14.4%).Androgen Precursors: In addition to DHEA, other androgen precursors like epiandrosterone also increased (+39%).
Aromatase Inhibition: DCI is believed to act as an aromatase down-modulator (inhibitor), reducing the conversion of androgens (like testosterone) into estrogens (like estradiol and estrone).
D-chiro-inositol (DCI) acts to mimic insulin and also stimulate PDHP (pyruvate dehydrogenase phosphatase), which in turn dephosphorylates and activates PDH (pyruvate dehydrogenase).
Acute Post-Meal Reduction: Clinical studies have shown that DCI, often in combination with myo-inositol, can acutely reduce the insulin spike that typically follows glucose or carb intake.
Improved Sensitivity: By enhancing the activation of the insulin receptor pathway (specifically IRS2 and GLUT4), DCI allows the insulin already present in your system to work more effectively.
Sparing Effect: Because DCI mimics certain insulin actions—like promoting glucose uptake into muscle and fat—it can have an insulin-sparing effect, meaning the body achieves the same blood sugar control with lower systemic insulin levels.taking D-chiro-inositol (DCI) or similar mimetics with carbohydrates can reduce the body's overall need for insulin by improving how cells process glucose.