Melatonin reverses warburg effect
-
Melatonin acts as a potent anti-Warburg agent in cancer cells by inhibiting aerobic glycolysis, reducing lactate production, and reversing the metabolic shift towards oxidative phosphorylation (OXPHOS). It suppresses tumor growth by re-routing pyruvate into the mitochondria, inhibiting key enzymes like pyruvate dehydrogenase kinase (PDK), and promoting apoptosis in various cancer cell lines.
Key Aspects of Melatonin's Impact on the Warburg Effect:
Inhibition of Aerobic Glycolysis: Melatonin reduces the rapid consumption of glucose and lactate production (the hallmarks of the Warburg effect) in cancer cells.
Reversing Metabolic Shift: It suppresses the Warburg effect by forcing pyruvate to enter the mitochondria for conversion into acetyl-CoA, rather than being converted into lactic acid in the cytoplasm.
Molecular Targets: Melatonin downregulates key metabolic pathways, including the pentose phosphate pathway, and inhibits HIF-1
, a transcription factor that drives glycolysis.By forcing cancer cells to return to a more normal metabolic state, melatonin reduces their survival and proliferation, making it a promising candidate for adjuvant therapy in cancer treatment.
Melatonin redirects pyruvate from lactate production in the cytosol to mitochondrial acetyl-CoA formation, reversing aerobic glycolysis in cancer cells like hepatocellular carcinoma (HuH 7.5) and ovarian cancer (SKOV-3). This reduces glucose uptake, lactate dehydrogenase activity, and cell proliferation while enhancing oxidative phosphorylation. In Ewing sarcoma models, it inhibits HIF-1α-driven glycolysis, sparing non-Warburg cells.
Melatonin lowers elevated lactate-to-pyruvate ratios in stress-induced muscle atrophy by curbing oxidative stress and boosting Na+/K+ ATPase activity. It boosts lactate-to-pyruvate interconversion and cuts lactate output in cancer lines, independent of MT1 receptors in some cases.These shifts support metabolic health beyond oncology, like in retinal ischemia.Just a few studies
https://pmc.ncbi.nlm.nih.gov/articles/PMC7828708/https://pubmed.ncbi.nlm.nih.gov/36863486/
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0135420
This could be a strong reason behind why having an optimal circadian rythm lowers cancer risk
-
When a family member went for radiation after cancer, I made up a topical with melatonin as the star ingredient.
The doctor was flabbergasted because she had not a trace of burns or redness in that area. He had never seen anyone get irradiated without some skin redness or burns.
Edited to add: I realize this has nothing to do (maybe) with the Warburg effect and melatonin…or does it…?
-
@Ecstatic_Hamster what other ingredients did you add?
-
@alfredoolivas cannabis, full spectrum oil, and lanolin.
-
Di Bella method is very successful in many difficult cancers
It usues somatostatin and melatonin.http://www.metododibella.org/it/Archivio-Newsletter.html
https://www.metododibellaevidenzescientifiche.com/2022/05/03/mdb001-di-bella-et-al-2018/
Il sinergismo di somatostatina, melatonina, retinoidi, vitamin E, D3, C, inibitori prolattinici ed estrogenici, microdosi metronomiche di ciclofosfamide, ha incrementato sopravvivenza, risposte obiettive, performance status, in 297 casi di carcinomi del seno – The Synergism of Somatostatin, Melatonin, Vitamins Prolactin and Estrogen Inhibitors Increased Survival, Objective Response and Performance Status In 297 Cases of Breast Cancer
