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    The anti-cortisol mechanism of trenbolone

    Scheduled Pinned Locked Moved Literature Review
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    • alfredoolivasA Offline
      alfredoolivas
      last edited by alfredoolivas

      82597122-f42d-4f60-81c5-e09c84883472-image.png

      Increases conversion of tryptophan into kynurenine pathway. Possibly reducing serotonin. Decreased catabolism too
      http://pubmed.ncbi.nlm.nih.gov/40858/

      HED: 0.13mg/kg TBA a day.

      alfredoolivasA 2 Replies Last reply Reply Quote 1
      • alfredoolivasA Offline
        alfredoolivas @alfredoolivas
        last edited by

        5904665a-1a48-4a5b-adb7-59dcac88d37d-image.png

        Methyl Tren increases fertility of females.
        https://pubmed.ncbi.nlm.nih.gov/528432/#:~:text=DOI%3A-,10.2527/jas1979.493729x,-No abstract available

        1 Reply Last reply Reply Quote 1
        • alfredoolivasA Offline
          alfredoolivas @alfredoolivas
          last edited by

          0.13mg/kg TBA a day was more effective than 2.5mg/kg TBA in supressing TAT.

          alfredoolivasA 1 Reply Last reply Reply Quote 1
          • alfredoolivasA Offline
            alfredoolivas @alfredoolivas
            last edited by

            "in France, the average weight for seniors tends to be around 66-67 kg"

            For these people, 7mg a day of tren would supress TAT by 30%. This is what Parabolan would deliver shortly after the first injection

            sunsunsunS 1 Reply Last reply Reply Quote 0
            • sunsunsunS Offline
              sunsunsun @alfredoolivas
              last edited by

              interdasting

              1 Reply Last reply Reply Quote 1
              • alfredoolivasA Offline
                alfredoolivas @engineer
                last edited by alfredoolivas

                @engineer bodybuilders are now starting to realise how powerful it is in low doses. Vigorous Steve was the one that put me onto this a year ago. It’s 8x more anabolic than testosterone, so of course they will abuse it and inject more.

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                • alfredoolivasA Offline
                  alfredoolivas
                  last edited by alfredoolivas

                  Lowers prolactin and GH as well as insulin the most.
                  1ae745f2-bb35-47f2-aa6e-1d30b0a78d53-image.png
                  https://www.cambridge.org/core/journals/animal-science/article/abs/effect-of-trenbolone-on-acetate-growth-blood-hormones-and-metabolites-and-nitrogen-balance-of-beef-heifers/8B3677C602A7E26F05252173EBBD474C

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                  • alfredoolivasA Offline
                    alfredoolivas
                    last edited by alfredoolivas

                    4c8871c5-287b-48c8-9a06-aa54ad7e0a1f-image.png

                    It decreases faty acid synthase, ACC in liver, adipose and muscle and LIPOLYSIS IN ADIPOSE TISSUE. It increases lipolysis in the liver and muscle, but allows adipose tissue to not release FFA into the blood!
                    10.1055/s-2007-1018919

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                    • alfredoolivasA Offline
                      alfredoolivas
                      last edited by

                      Seems to make turkeys with weak legs more excitable, indicating it increases intracellular calcium
                      cfec36a0-9054-4353-aac0-d92faa12e3bc-image.png

                      10.1080/00071688108447879

                      alfredoolivasA 1 Reply Last reply Reply Quote 0
                      • alfredoolivasA Offline
                        alfredoolivas @alfredoolivas
                        last edited by

                        " the anabolic action of TP and TBA, especially in female rats, may be mediated through an antagonistic effect to the catabolic effects of oestrogens and glucocorticoids."
                        https://www.semanticscholar.org/paper/Effect-of-sex%2C-testosterone-propionate-and-acetate-Santidrián-Thompson/64ece3bf3a3cd424d83611cfad2d54f94912c41c

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                        • alfredoolivasA Offline
                          alfredoolivas
                          last edited by alfredoolivas

                          decreases FFA " Plasma triglyceride concentrations in all
                          implanted groups fell markedly by week 5 and remained well
                          below control values until slaughter. The concentration of
                          plasma non-esterified fatty acids decreased by approximately
                          50% in all four treatment groups
                          "

                          b6eb3ab6-0ebb-40ad-b7a7-ed03abace780-image.png

                          f4366e4a-b08a-4a61-95b5-1ff3cedf07b4-image.png

                          Low doses of tren & E2 had lower cholesterol.

                          https://pubmed.ncbi.nlm.nih.gov/7152469/

                          1 Reply Last reply Reply Quote 0
                          • alfredoolivasA Offline
                            alfredoolivas
                            last edited by

                            "TB A also had no effect on either the digestibility or metabolizability of the energy in the diet, or on the total energy retained by the two experimental groups...there were significant differences in the way this energy was partitioned for growth between treated and control animals. "

                            It doesn't cause fat loss via increasing metabolism?

                            https://www.researchgate.net/publication/231925431_The_effect_of_trenbolone_acetate_on_growth_rate_and_carcass_composition_of_young_female_rabbits

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                            • alfredoolivasA Offline
                              alfredoolivas
                              last edited by

                              " Trenbolone, however, did not demonstrate any genotoxic effect in the assays performed."
                              https://pubmed.ncbi.nlm.nih.gov/3090982/

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                              • alfredoolivasA Offline
                                alfredoolivas
                                last edited by alfredoolivas

                                a2097a76-0e88-4866-88ac-9d05c7ba9277-image.png
                                Decreases fat cell size

                                adef3e8f-aea9-457c-9d38-217b5e58d4a8-image.png
                                Decreases FAS and increases G6PD and other genes involved with NADPH formation

                                https://pubmed.ncbi.nlm.nih.gov/3583947/

                                200mg TBA implant given once every 56 days with a 60 day withdrawal period.

                                I am not going to even estimate the amount of tren built up and released lol

                                But that is 3.57mg TBA (2.85mg elemental weight) every day given to Heifers, with a 60 day withdrawal period.
                                9dd8310f-fc83-4fff-94fd-8a5140cc2e82-image.png

                                French were giving 5mg a day to 65kg humans XDXD.
                                Bro if 2.85mg of trenbolone can do this to a HEIFER after 60 days of no tren then imagine what 5mg does to a human @engineer

                                alfredoolivasA 1 Reply Last reply Reply Quote 0
                                • alfredoolivasA Offline
                                  alfredoolivas @alfredoolivas
                                  last edited by

                                  I think tren only cycles may be good, because OVX with tren was often more effective than tren by itself.

                                  Lowering endogenous sex steroids like progesterone, estradiol and test WITH tren can be even more anti-lipolitc.

                                  bee75c2e-c1dc-4265-a5b3-6727cd26da85-image.png

                                  alfredoolivasA 1 Reply Last reply Reply Quote 0
                                  • alfredoolivasA Offline
                                    alfredoolivas @alfredoolivas
                                    last edited by

                                    @sunsunsun my inuition may be correct😉 😉

                                    @sunsunsun said in moggy chicken log:

                                    @alfredoolivas but why u think androstane avoidance is le good

                                    @alfredoolivas said in moggy chicken log:

                                    @sunsunsun intuition😉

                                    sunsunsunS 1 Reply Last reply Reply Quote 0
                                    • sunsunsunS Offline
                                      sunsunsun @alfredoolivas
                                      last edited by

                                      @alfredoolivas y tho

                                      alfredoolivasA 1 Reply Last reply Reply Quote 0
                                      • alfredoolivasA Offline
                                        alfredoolivas @sunsunsun
                                        last edited by alfredoolivas

                                        @sunsunsun What are your questions?

                                        It's really effective in quite low doses. Heifer to HED dose is pretty similar. If 2.85mg of TBA a day (the estimated amount when they were slaughtered) had 28% less FAS, smaller fat cells or 700mcg doses having 63% less GR expression & less cortisol, 2mg having 75% less GR in rats. It also decreases FFA & Lipolysis in fat, whilst having these moderate fat loss effcts in these low doses, which is quite rare.

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                                        • alfredoolivasA Offline
                                          alfredoolivas
                                          last edited by

                                          Trenboloen decreases aromatase:

                                          " The results indicated that 17β-trenbolone exposure decreased the number of primordial germ cells at 1 dpf and 3 dpf, decreased expression of ovarian differentiation-related genes foxl2 and cyp19a1a at 60 dpf, increased expression of testis differentiation-related genes dmrt1"

                                          "Cyp19a1a (cytochrome P450, family 19, subfamily A, polypeptide 1a) is a crucial gene in teleost fish that encodes gonadal aromatase, an enzyme responsible for converting androgens into estrogens to drive ovarian development."

                                          https://www.researchgate.net/publication/355334496_17b-Trenbolone_binds_to_androgen_receptor_decreases_number_of_primordial_germ_cells_modulates_expression_of_genes_related_to_sexual_differentiation_and_affects_sexual_differentiation_in_zebrafish_Dani

                                          engineerE 1 Reply Last reply Reply Quote 0
                                          • engineerE Offline
                                            engineer @alfredoolivas
                                            last edited by

                                            @alfredoolivas are you using LDT right now to achieve moggy chicken?

                                            1 Reply Last reply Reply Quote 0
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