The anti-cortisol mechanism of trenbolone
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" the anabolic action of TP and TBA, especially in female rats, may be mediated through an antagonistic effect to the catabolic effects of oestrogens and glucocorticoids."
https://www.semanticscholar.org/paper/Effect-of-sex%2C-testosterone-propionate-and-acetate-Santidrián-Thompson/64ece3bf3a3cd424d83611cfad2d54f94912c41c -
decreases FFA " Plasma triglyceride concentrations in all
implanted groups fell markedly by week 5 and remained well
below control values until slaughter. The concentration of
plasma non-esterified fatty acids decreased by approximately
50% in all four treatment groups"
Low doses of tren & E2 had lower cholesterol.
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"TB A also had no effect on either the digestibility or metabolizability of the energy in the diet, or on the total energy retained by the two experimental groups...there were significant differences in the way this energy was partitioned for growth between treated and control animals. "
It doesn't cause fat loss via increasing metabolism?
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" Trenbolone, however, did not demonstrate any genotoxic effect in the assays performed."
https://pubmed.ncbi.nlm.nih.gov/3090982/ -
Decreases fat cell size
Decreases FAS and increases G6PD and other genes involved with NADPH formationhttps://pubmed.ncbi.nlm.nih.gov/3583947/
200mg TBA implant given once every 56 days with a 60 day withdrawal period.
I am not going to even estimate the amount of tren built up and released lol
But that is 3.57mg TBA (2.85mg elemental weight) every day given to Heifers, with a 60 day withdrawal period.
French were giving 5mg a day to 65kg humans XDXD.
Bro if 2.85mg of trenbolone can do this to a HEIFER after 60 days of no tren then imagine what 5mg does to a human @engineer -
I think tren only cycles may be good, because OVX with tren was often more effective than tren by itself.
Lowering endogenous sex steroids like progesterone, estradiol and test WITH tren can be even more anti-lipolitc.
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@sunsunsun my inuition may be correct
@sunsunsun said in moggy chicken log:
@alfredoolivas but why u think androstane avoidance is le good
@alfredoolivas said in moggy chicken log:
@sunsunsun intuition
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@alfredoolivas y tho
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@sunsunsun What are your questions?
It's really effective in quite low doses. Heifer to HED dose is pretty similar. If 2.85mg of TBA a day (the estimated amount when they were slaughtered) had 28% less FAS, smaller fat cells or 700mcg doses having 63% less GR expression & less cortisol, 2mg having 75% less GR in rats. It also decreases FFA & Lipolysis in fat, whilst having these moderate fat loss effcts in these low doses, which is quite rare.
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Trenboloen decreases aromatase:
" The results indicated that 17β-trenbolone exposure decreased the number of primordial germ cells at 1 dpf and 3 dpf, decreased expression of ovarian differentiation-related genes foxl2 and cyp19a1a at 60 dpf, increased expression of testis differentiation-related genes dmrt1"
"Cyp19a1a (cytochrome P450, family 19, subfamily A, polypeptide 1a) is a crucial gene in teleost fish that encodes gonadal aromatase, an enzyme responsible for converting androgens into estrogens to drive ovarian development."
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@alfredoolivas are you using LDT right now to achieve moggy chicken?
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Decreases metabolic rate. This could be becayse they were eating less. T3 dropped by 0.3. So it doesn't cause fat loss by increasing metabolism. Mifeprestone also doesn't increase the metabolic rate and causes weight loss, so it could be due to supression of lipogenic pathways and less appetiete
Also found this interesting part
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"A combined implant of 17 beta-estradiol trenbolone acetate in young male goats decreased blood glucose and insulin 28 d after treatment, but had no effect on growth or thyroid hormones. No relation was found between hormonal concentrations and growth performance."
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"
Trenbolone greatly decreases corticosterone and ACTH, whreas testosterone increases it!!!
https://pubmed.ncbi.nlm.nih.gov/2170557/]]0.1296mg/kg HED.
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"Interestingly, potent anabolic steroid trenbolone bound to the glucocorticoid receptor with an affinity almost as high as that of corticosterone, the endogenous glucocorticoid in the rat " not cortisol ik
10.1016/0022-4731(86)90109-3 -
https://avmajournals.avma.org/view/journals/ajvr/52/2/ajvr.1991.52.02.282.xml?tab_body=pdf
Trenbolone derivative, via being a progestin, can treat endotoxinemia
"Evaluation of progesterone deficiency as a cause of fetal death in mares with experimentally induced endotoxemia"
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decreased cholesterol and FFA
10.2527/1993.71102659x -
It seems to decrease cholesterol, prolactin, increase heart rate slightly and temps remain neutral.
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Decreases desaturase enzymes (estradiol was added to too). Other studies show it increases SFA to MUFA ratio
10.2527/jas.2006-280 -
decreases beta 1, beta 3 adrenaline receptors but increase beta 2
10.1111/j.1439-0396.2007.00675.x
I hypothesise that it is adrenergic but anti cortisol, because of the study that suggested it was excitable and calcium handling may be altered
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