The anti-cortisol mechanism of trenbolone
-
Decreases metabolic rate. This could be becayse they were eating less. T3 dropped by 0.3. So it doesn't cause fat loss by increasing metabolism. Mifeprestone also doesn't increase the metabolic rate and causes weight loss, so it could be due to supression of lipogenic pathways and less appetiete
Also found this interesting part
-
"A combined implant of 17 beta-estradiol trenbolone acetate in young male goats decreased blood glucose and insulin 28 d after treatment, but had no effect on growth or thyroid hormones. No relation was found between hormonal concentrations and growth performance."
-
"
Trenbolone greatly decreases corticosterone and ACTH, whreas testosterone increases it!!!
https://pubmed.ncbi.nlm.nih.gov/2170557/]]0.1296mg/kg HED.
-
"Interestingly, potent anabolic steroid trenbolone bound to the glucocorticoid receptor with an affinity almost as high as that of corticosterone, the endogenous glucocorticoid in the rat " not cortisol ik
10.1016/0022-4731(86)90109-3 -
https://avmajournals.avma.org/view/journals/ajvr/52/2/ajvr.1991.52.02.282.xml?tab_body=pdf
Trenbolone derivative, via being a progestin, can treat endotoxinemia
"Evaluation of progesterone deficiency as a cause of fetal death in mares with experimentally induced endotoxemia"
-
decreased cholesterol and FFA
10.2527/1993.71102659x -
It seems to decrease cholesterol, prolactin, increase heart rate slightly and temps remain neutral.
-
Decreases desaturase enzymes (estradiol was added to too). Other studies show it increases SFA to MUFA ratio
10.2527/jas.2006-280 -
decreases beta 1, beta 3 adrenaline receptors but increase beta 2
10.1111/j.1439-0396.2007.00675.x
I hypothesise that it is adrenergic but anti cortisol, because of the study that suggested it was excitable and calcium handling may be altered
-
It decreases brain aromatase
It increases ERb, but so does the aromatase inhibitor fedarazole
10.1897/08-082.1
-
Increases gonad size
10.1016/j.marenvres.2009.09.009 -
"co-treatment with 17-TBOH and flutamide (an AR antagonist) also results in anti-estrogenic activity in female fathead minnows"
"17-TBOH, alone or in combination with 17- E2, has been shown to increase the cross-sectional area (CSA) of type I, but not type II, skeletal muscle fibers and induce a fiber switch from more glycolytic to more oxidative fibers, J.F. Yarrow et al. / Steroids 75 (2010) 377–389 381 indicating an increase in the oxidative capacity of skeletal muscle [152,189]. "
"As a result of its anti-glucocorticoid actions, 17-TBOH produces a more robust inhibition of protein degradation than does testosterone, which only slightly reduces protein degradation while increasing protein synthesis "
"Preliminary evidence from our laboratory indicates that the enanthate ester of 17-TBOH protects against hypogonadism induced cancellous bone loss to the same extent as supraphysiological testosterone
"In our hands, the lipolytic effects of 17-TBOH-enanthate are even more potent than that of supraphysiological testosterone-enanthate (unpublished laboratory results)"
10.1016/j.steroids.2010.01.019
-
Trenbolone is a Carbonic Anhydrase Inhibitor
10.3109/14756366.2011.584535
-
Decreases desaturase enzymes
10.2527/jas.2011-3496 -
Trenbolone derivative is anti estrogenic
The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus) -
I suspected the membrane receptors such as the membrane estrogen receptors to be the cause of trenboloens side effects, might be true
https://pubmed.ncbi.nlm.nih.gov/26440329/
https://pubmed.ncbi.nlm.nih.gov/27285910/ -
Tren decreases estrogen receptors A and B & aromatase in the brain
https://pubmed.ncbi.nlm.nih.gov/26098908/ -
"To address this, we exposed wild male guppies (Poecilia reticulata) to an environmentally realistic concentration of 17β-trenbolone (average measured concentration: 8 ng/L) for 21 days using a flow-through system. We found that, in the presence of a competitor, 17β-trenbolone-exposed males carried out more frequent aggressive behaviours towards rival males than did unexposed males, as well as performing less courting behaviour and more sneak (i.e., coercive) mating attempts towards female"
https://pubmed.ncbi.nlm.nih.gov/28854383/
Basically nanogram doses of tren turned "guppies"? into rapists with no intent for marriage
-
No point in doing trenbolone in florida @engineer
"Specifically, significant effects of trenbolone on male predator escape behavior were only noted at 30 °C, with males becoming less reactive to the simulated threat. Further, in the maze experiment, trenbolone-exposed fish explored the maze faster than control fish, but only at 20 °C. "
http://pubmed.ncbi.nlm.nih.gov/30423539/ -
"Melatonin attenuates 17beta-trenbolone induced insomnia-like phenotype and movement deficiency in zebrafish."
10.1016/j.chemosphere.2020.126762
Hello! It looks like you're interested in this conversation, but you don't have an account yet.
Getting fed up of having to scroll through the same posts each visit? When you register for an account, you'll always come back to exactly where you were before, and choose to be notified of new replies (either via email, or push notification). You'll also be able to save bookmarks and upvote posts to show your appreciation to other community members.
With your input, this post could be even better 💗
Register Login