The anti-cortisol mechanism of trenbolone
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Increases gonad size
10.1016/j.marenvres.2009.09.009 -
"co-treatment with 17-TBOH and flutamide (an AR antagonist) also results in anti-estrogenic activity in female fathead minnows"
"17-TBOH, alone or in combination with 17- E2, has been shown to increase the cross-sectional area (CSA) of type I, but not type II, skeletal muscle fibers and induce a fiber switch from more glycolytic to more oxidative fibers, J.F. Yarrow et al. / Steroids 75 (2010) 377–389 381 indicating an increase in the oxidative capacity of skeletal muscle [152,189]. "
"As a result of its anti-glucocorticoid actions, 17-TBOH produces a more robust inhibition of protein degradation than does testosterone, which only slightly reduces protein degradation while increasing protein synthesis "
"Preliminary evidence from our laboratory indicates that the enanthate ester of 17-TBOH protects against hypogonadism induced cancellous bone loss to the same extent as supraphysiological testosterone
"In our hands, the lipolytic effects of 17-TBOH-enanthate are even more potent than that of supraphysiological testosterone-enanthate (unpublished laboratory results)"
10.1016/j.steroids.2010.01.019
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Trenbolone is a Carbonic Anhydrase Inhibitor
10.3109/14756366.2011.584535
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Decreases desaturase enzymes
10.2527/jas.2011-3496 -
Trenbolone derivative is anti estrogenic
The use of altrenogest to avoid hyperestrogenism after eCG-hCG ovulation induction in southern tigrina (Leopardus guttulus) -
I suspected the membrane receptors such as the membrane estrogen receptors to be the cause of trenboloens side effects, might be true
https://pubmed.ncbi.nlm.nih.gov/26440329/
https://pubmed.ncbi.nlm.nih.gov/27285910/ -
Tren decreases estrogen receptors A and B & aromatase in the brain
https://pubmed.ncbi.nlm.nih.gov/26098908/ -
"To address this, we exposed wild male guppies (Poecilia reticulata) to an environmentally realistic concentration of 17β-trenbolone (average measured concentration: 8 ng/L) for 21 days using a flow-through system. We found that, in the presence of a competitor, 17β-trenbolone-exposed males carried out more frequent aggressive behaviours towards rival males than did unexposed males, as well as performing less courting behaviour and more sneak (i.e., coercive) mating attempts towards female"
https://pubmed.ncbi.nlm.nih.gov/28854383/
Basically nanogram doses of tren turned "guppies"? into rapists with no intent for marriage
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No point in doing trenbolone in florida @engineer
"Specifically, significant effects of trenbolone on male predator escape behavior were only noted at 30 °C, with males becoming less reactive to the simulated threat. Further, in the maze experiment, trenbolone-exposed fish explored the maze faster than control fish, but only at 20 °C. "
http://pubmed.ncbi.nlm.nih.gov/30423539/ -
"Melatonin attenuates 17beta-trenbolone induced insomnia-like phenotype and movement deficiency in zebrafish."
10.1016/j.chemosphere.2020.126762
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"The results conclude that nandrolone decanoate, but neither testosterone decanoate nor trenbolone decanoate, caused impaired recognition memory in the NOR-test, indicating an altered cognitive function. The behavioral profile and stress hormone level of the rats were not affected by the AAS treatments. Furthermore, the study revealed diverse AAS-induced somatic effects i.e., reduced body weight development and changes in organ weights. Of the three AAS included in the study, nandrolone decanoate was identified to cause the most prominent impact on the male rat, as it affected body weight development, the weights of multiple organs, and caused an impaired memory function."
https://pmc.ncbi.nlm.nih.gov/articles/PMC8974338/ -
"In conclusion, our findings indicate that while 17-TB mitigates muscle atrophy and enhances motor activity in PD mice, it concurrently exacerbates neuroinflammation, induces neuronal apoptosis, and worsens dopaminergic neuronal death"
https://pubmed.ncbi.nlm.nih.gov/39222261/
