The anti-cortisol mechanism of trenbolone
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@alfredoolivas The methyl groups are probably better for AR binding, as you suggest. Actually, something similar is the case with methamphetamine. Methamphetamine is a better stimulant than ethylamphetamine.
THG has an ethyl group not for some special reason to do with the ethyl being "better" but because of two reasons 1) the precursors PA was working with (norgestrel) 2) even if PA could have made THG with methyl instead of ethyl at 17-A he wouldn't have because he wanted to make something undetectable and I believe the 17-A ethyl group made it undetectable because it was metabolized into compounds that no algorithm at the time analyzing the breakdown products in urine could detect
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@jamezb46 what were the doses of the clear? Idk why methylated steroids were chosen, because you can just take more of the ethyl steroid and have the same endocrine effects without hepatoxicity
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@alfredoolivas tiny doses, similar to mtren.
Ethylated steroid are also hepatotoxic, probably more so than methylated actually
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@jamezb46 Oh I was under the impression they were less.
RU486 has an ethyl group and is used in >gram doses. It is liver toxic, but far less so than other methylated steroids used in thousandths of the doses of ru486. -
@alfredoolivas Well, I think it depends on a number of factors. For example, Danazol is taken in the hundreds of mg range, and it has the ethnyl group. Note this is not the same moiety as an ethyl group, it is ethnyl, not ethyl. I actually don't know of any steroid (progestogin,androgen, etc.) that has an ethyl instead of a methyl at 17-A. The progestins have Ethnyl, not Ethyl.
Only exception I can find is THG, which has ethyl instead of ethnyl, PA must have figured out that changing from ethnyl to ethyl makes the compound better in some important way, either increasing AR binding or reducing breakdown. THG was synthesized from Gestrinone, and Gestrinone has ethnyl on 17-A.
BTW: PA refers to the ethnyl group as "an acetylene group" in some interviews, which is informal.
It might actually be worth trying to get your hands on some Danazol or Gestrinone because they're androgenic
In time there is life but no knowledge; outside time there is knowledge but no life
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@jamezb46 Bro I would sell my kideny for a gram of gestrinone
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@jamezb46 Any thoughts on stanazol and halotestin?
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Don't know much about them but apparently real halotestin is fairly safe and JFK was on it.
Obviously there's a reason why BBers use winstrol but I don't think its anything special for non-competitors.
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20~mgs of tren base every day for two months made my clavicles noticeably wider, could literally feel the increased calcium demands by taste.
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@ethan This is my favorite schizophrenic comment on this forum so far
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@alfredoolivas Don't know where you're getting your info on RU486 but according to its wikipedia page it doesn't have Ethyl on 17-A, it has 1-propynyl.
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@jamezb46 chatGPT slop forgive me. I can’t destinguish funcitonal groups well.
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@alfredoolivas fuck AI
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