The anti-cortisol mechanism of trenbolone
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@alfredoolivas Well, I think it depends on a number of factors. For example, Danazol is taken in the hundreds of mg range, and it has the ethnyl group. Note this is not the same moiety as an ethyl group, it is ethnyl, not ethyl. I actually don't know of any steroid (progestogin,androgen, etc.) that has an ethyl instead of a methyl at 17-A. The progestins have Ethnyl, not Ethyl.
Only exception I can find is THG, which has ethyl instead of ethnyl, PA must have figured out that changing from ethnyl to ethyl makes the compound better in some important way, either increasing AR binding or reducing breakdown. THG was synthesized from Gestrinone, and Gestrinone has ethnyl on 17-A.
BTW: PA refers to the ethnyl group as "an acetylene group" in some interviews, which is informal.
It might actually be worth trying to get your hands on some Danazol or Gestrinone because they're androgenic
In time there is life but no knowledge; outside time there is knowledge but no life
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@jamezb46 Bro I would sell my kideny for a gram of gestrinone
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@jamezb46 Any thoughts on stanazol and halotestin?
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Don't know much about them but apparently real halotestin is fairly safe and JFK was on it.
Obviously there's a reason why BBers use winstrol but I don't think its anything special for non-competitors.
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20~mgs of tren base every day for two months made my clavicles noticeably wider, could literally feel the increased calcium demands by taste.
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@ethan This is my favorite schizophrenic comment on this forum so far
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@alfredoolivas Don't know where you're getting your info on RU486 but according to its wikipedia page it doesn't have Ethyl on 17-A, it has 1-propynyl.
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@jamezb46 chatGPT slop forgive me. I can’t destinguish funcitonal groups well.
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@alfredoolivas fuck AI
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alfredoolivas said:
"Interestingly, potent anabolic steroid trenbolone bound to the glucocorticoid receptor with an affinity almost as high as that of corticosterone, the endogenous glucocorticoid in the rat "
Corticosterone binds to the GR in hepatoma cells as MORE than cortisol.
So at least in rat liver cancer cells, trenbolone has an equal affinity as cortisol on the GR, antagonising it.
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