I need help trying to figure out what’s wrong with me
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I’ve been chronically sick since 2018. One moment of I was fine then the next moment I felt poisoned. I remember it very vividly. And since then nothing has been ok and I’ve only gotten worse.
Some things I think are relavent to me trying to figure some of this out are
- Since 2018 I’ve completely lost the ability to sweat.
-I’ve completely lost the ability to feel thirst
-I’ve completely lost the ability to make stomach acid
-I’ve completely lost the ability to have acute illness symptoms (so cannot “get sick” or get fever ) - Despite normal blood work i have very low blood volume.
-A lot of air hunger sensations especially after fresh air - Muscle fasciculations all over, major weakness, dizziness etc.
- Aldosterone elevated in blood , serotonin elevated in blood, estrogen (e1,e2,e3) all elevated in urine test
- Severe breathing issues and 24/7 wheezing developed during Fludrocortisone treatment in 2023 for POTS , and then prednisone seemed to make it worse
-Normal thyroid blood work but signs of hypothyroid like low body temp. I’ve tried ramping up glucose and dextrose but didn’t really help and supplemtning t3 but It didn’t really help.
-Burning all over - feel poisoned all the time.
-drinking modest amounts of potassium (1/4 dose of rda )results in tingling all over.
My body feels like it’s in some hibernation mode. Just not doing what it’s supposed to be doing. I’ve tried many things to no avail
Some things I’ve been considering but don’t know much about -
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Some kind of metabolic alkalosis or acidosis- Perhaps low chloride causing low blood volume - thus raising the aldosterone. Supplementing salt pills (4-5 grams a day) hasn’t solved any issue though with blood volume or stomach acid production. Or lowering serotonin. It’s almost like I could be aldosterone resistant since with high aldosterone you’d expect increased blood volume not lower.
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This posioned sensation started on 2018 while I was drinking alcholol. I thought my drink was spiked at first. Next day woke up and had the weirdest (and last) acute illness I’ve ever experienced. I had a brutal cough but couldn’t cough anything out. It was like my body failed at what it was trying to clear. I think some major toxicity issue is occurring and I still have not figured out how to fix it. I’ve considered it may be bile leakage as eating and drinking makes the sensation far worse. I have NAFLD and very poor bile flow and major constipation.
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Some kind of major metaboslim issue like hypothyroidism. I have all the signs but supplemting thyroid just never helps and my t3 and reverse t3 all looks normal. Increasing glucose did nothing. I’ve even tried that dextorse protocol and didn’t seem to help.
Not being able to sweat, feel thirst, get sick, make stomach acid, get a fever. My body is shutting down. I’m barely able to walk and stand and eat which I know is an issue. I can really only tolerate meat mostly but try to get carbs too. Everything around me is falling apart and I need some help trying to figure out why my body is not doing so many important things.
- Since 2018 I’ve completely lost the ability to sweat.
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Hi,
Sorry to hear that.
One clue: Dysautonomia
Dysautonomia is a disorder of the autonomic nervous system (ANS), where the nerves that control involuntary bodily functions—like breathing, heart rate, blood pressure, digestive issues such as nausea, and temperature—don't function properly. This malfunction leads to a wide range of disruptive symptoms and problems with fatigue and exercise intolerance or difficulty in controlling body temperature.
Thiamine (Vitamin B1) impacts dysautonomia by being essential for energy metabolism in nerve and muscle cells, and its deficiency can cause or mimic autonomic nervous system (ANS) dysfunction. Symptoms like fatigue, dizziness, and muscle weakness, seen in thiamine deficiency, also occur in dysautonomia. Correcting a thiamine deficiency with supplementation can lead to significant symptom relief in some dysautonomia patients.
See Elliot Overton (nutritionist) if you want confirmation on dysautonomia (3) and Dr. Antonio Constantini (neurologist).
Note that some people aren’t suffering from what we call a nutrient deficiency but from a metabolic block. Dependent-B1 enzymes are blocked / inactivated due to some “stress factors” (see figure): chemical and environmental toxins, chronic inflammation and / or infection.
Figure 1: Thiamine-dependent enzyme blocked in energy and global metabolism
Note: Not a lack but enzymes blocked.
KGDHC = α-ketoglutarate dehydrogenase complex = dependent-B1 enzymes.
Credit: Elliot Overton (nutritionist) and Dr. Antonio Constantini (Italian neurologist)
Warning: When taking high dose thiamine, there is a protocol to follow. There is interaction with other vitamins. For example taking 100 mg, then afterwards 500 mg of thiamine (the TTFD kind is advised for the brain penetration) will deplete the other cofactors involved in the assimilation of thiamine. See the advised protocol further by Elliot Overton (hallmark N° 14).
Why a high dose vitamin B1 and not only the RDA? We need HD B1 to get a beneficial passive assimilation by the body. Transport carriers are limited.
See comment on my forum before plunging into the video of Overton (rather long):
English corner: Disruption in coordination with fatigue and exercise intolerance, temp & intestinal problems
Metabolic block: Brain & intestinal system affected by thiamine deficiency
https://mirzoune-ciboulette.forumactif.org/t2127-english-corner-disruption-in-coordination-with-fatigue-and-exercise-intolerance-temp-intestinal-problems#30304 -
2018's quite a while ago. Are you tracking your body weight and do you have any vision problems?
Alcolol's definitely liable to cause a volume deficit. (Source, Britain.)
-drinking modest amounts of potassium (1/4 dose of rda )results in tingling all over.
Supplementing salt pills (4-5 grams a day) hasn’t solved any issue though with blood volume or stomach acid production.
What's wrong with fruit, juice with a bit (a bit!) of added sugar and a pinch of salt, and lightly salting your food? This way you could try and... inflate yourself slowly over a few days. Eat 3 spaced meals, ignore your a sluggish sense of hunger or digestion. IME there's a point where the distal stomach starts eating it the other way, when you know the ignition is on.
And you've mentioned being unable to sense thirst but you didn't say anything about water. Are you drinking any? Maybe minimise that.
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will you sweat if you go into a sauna?
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Hi, yes I do have dysautonomia. I’ve tried mega dosing allithiamine , thiamine hcl and beforthiamine at various different times over the years. Unfortunately it hadn’t helped really at all. I don’t know maybe i can’t absorb it properly with low hcl?
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I’m 150 lbs and 6’2. I look sick but just last year I was 220lbs. I lost a lot fast I’ve been up and down throughout my illness.
Juice I seem to have issues with. I don’t know if I’m truly allergic to something in most juices or if it’s some mast cell thing. But I can drink liquid Ivs and things like that. I’ve went on binges of high electrolyte drinking trying to increase volume to no avail.
Alcholol seemed to kick off the whole thing years ago but I’ve steered clear of it since then. Trying to figure this volume depletion is so hard. For years I’d have chronic diarrhea which stopped last year. Bloodwork always remained normal.
I was doing some reading today about high serotonin blocking chloride and salt absorption in the gut. I wonder if this could be preventing the volume from expanding. My levels are chronically very high in the blood but don’t look bad in urine. Like I’m not making the breakdown of it. Its levels you’d see in carcinoid syndrome but I don’t have a tumour nor do I respond to antihistamines or octreotide.
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I’ve tried the sauna twice
Both times left me sprawled out on the floor gasping for breath with a 170 bpm heart rate. It takes a very long time and sweat is minimal. Like a couple drips.
I quickly realized my body is wanting to hang onto fluid for dear life and trying to sweat is a bad idea.
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@KM88 said:
I’m 150 lbs and 6’2. I look sick but just last year I was 220lbs. I lost a lot fast I’ve been up and down throughout my illness.Hmm.
My levels are chronically very high in the blood but don’t look bad in urine. Like I’m not making the breakdown of it. Its levels you’d see in carcinoid syndrome but I don’t have a tumour nor do I respond to antihistamines or octreotide.
Where are you getting these diagnostics? You're under observation/on a clinicians radar? Anything other notes on your renal function?
I was doing some reading today about high serotonin blocking chloride and salt absorption in the gut. I wonder if this could be preventing the volume from expanding.
Have you done any experiments with 1/4 a cypro and 1/2 an aspirin? Have you done anything with taurine?
Juice I seem to have issues with. I don’t know if I’m truly allergic to something in most juices or if it’s some mast cell thing. But I can drink liquid Ivs and things like that. I’ve went on binges of high electrolyte drinking trying to increase volume to no avail.
Check your gulps/chugs. Sip.
The whole oesophagus and stomach lining is supposed to do strangely intelligent things. You can find receipts for this.
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Copper?. Do you eat anything which may trigger hemolytic anemia? Such as methalyne blue etc i forgot other ones.
G6pd defeciency causes blood cells to be vunrable to many diffrent factors so testing yourself for it can be helpful.
The drink you took may have started a cascade of oxidative stress which caused blood cell die off
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@KM88 said:
I’m 150 lbs and 6’2. I look sick but just last year I was 220lbs. I lost a lot fast I’ve been up and down throughout my illness.Hmm.
My levels are chronically very high in the blood but don’t look bad in urine. Like I’m not making the breakdown of it. Its levels you’d see in carcinoid syndrome but I don’t have a tumour nor do I respond to antihistamines or octreotide.
Where are you getting these diagnostics? You're under observation/on a clinicians radar? Anything other notes on your renal function?
I was doing some reading today about high serotonin blocking chloride and salt absorption in the gut. I wonder if this could be preventing the volume from expanding.
Have you done any experiments with 1/4 a cypro and 1/2 an aspirin? Have you done anything with taurine?
Juice I seem to have issues with. I don’t know if I’m truly allergic to something in most juices or if it’s some mast cell thing. But I can drink liquid Ivs and things like that. I’ve went on binges of high electrolyte drinking trying to increase volume to no avail.
Check your gulps/chugs. Sip.
The whole oesophagus and stomach lining is supposed to do strangely intelligent things. You can find receipts for this.
I’ve tried Cypro and aspirin many times for extended periods. And at some pretty high doses as well. I recall taking up to 60mg Cypro one day as I saw it could help carcinoid syndrome. No help on resolving anything really. And also I’ve done taurine recently.
My respiraolgost ordered the serotonin. I’m suppose to see an endo but hasn’t happened. But it keeps coming back elevated in the blood. I don’t know if ite just a sign of how bad I’m doing or a direct cause of all this. But blocking it hasn’t been a game changer for the month or so I tried it.
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Copper?. Do you eat anything which may trigger hemolytic anemia? Such as methalyne blue etc i forgot other ones.
G6pd defeciency causes blood cells to be vunrable to many diffrent factors so testing yourself for it can be helpful.
The drink you took may have started a cascade of oxidative stress which caused blood cell die off
I have tried copper supplementation , even the supposed bioavailable kind.
The question is if it did , how would I stop it. I’ve tried every antioxidant under the sun. Maybe it’s an oxidizer I need. Hydrogen peroxide or something.
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@KM88 no antioxidant can help if you eat fava beans with a g6pd deficiency. Give us a rundown of your diet.
Where do you live which country city -
Agree with lobotomize, we need some information on your diet now and over the past years
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@KM88 barely able to walk sound like severe defiency,
Salt dont necessary increase digestion and can reduce digestion and increase foods/liquid reflux if you eat to much.
With the few elements you mentionned, and also initially triggered by alcohol, you should try ripe fruits and good quality dattes possibly, its pro movement/ease of movement and joints health. If this doesnt improve, with your current diet likely being muscle meat, you could be low in molydenum, selenium, manganese, so i suggest you experiment with foods high in these minerals or with supps if you are someone that do take supps. And i suggest you dont eat to much muscle meat per day.
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@KM88 said:
I don’t know if ite just a sign of how bad I’m doing or a direct cause of all this.Chicken and egg thing.
My respiraolgost ordered the serotonin. I’m suppose to see an endo but hasn’t happened. But it keeps coming back elevated in the blood.
How did you arrive at a respiratory? You didn't say anything about recent pulmonary issues, or it's not clear.
Did you take the most regularly recommended covid therapeutic, most commonly referred to as a vaccine?
And what else was going on in 2018? What do you do for a living, is it hard? (Be vague.)
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