Peptides straight from vendor - Analyzed bulk (Reta 30mg vials/motsC 40mg/GHK CU 100mg/SS31 50mg/BPC 20mg n so on
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Those are mad doses with no tangible evidence behind anything at all. It's also all fixed-ratio GLOW.
I had once delved into the zenith of copper research from the early 70's of the few researchers who had resisted the early-50s shift to everything corticosteroids. I may share it at some point. The baseline was that copper therapy, with its right chelators, is super antiinflammatory against RA and the usual suspects and may even be the actual main mechanism behind acetylsalicylic acid. The GHK-Cu may make sense in that light.
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@CrumblingCookie You can turn it around, claiming there are no evidence that low doses are effective. As almost all dosing on peptides are anecdotal. So its not really fair to claim his guys experience is nonsense
Tb500 was given in 50mg+ dosing IV for heart faliure for example (dont quote me on the dose but its around there, if not double) yet people can skip surgery by using 1mg every other day
Okey yes i belive it. I notice the anti inflammatory effect right away post injection. Copper also seem to be involved in regulating histamine (chronic pain, wich mcas cause RA btw), people with mcas are copper deficiant, but also vita D deficiant as that also control histamine the most.
It also increase oxygen n dopamine alot, its one of the most effective therapies ive used for mental health. Dont know if i can say the 5mg vs 10mg effect is any different when it comes to the mental effects
Just remembered there are studies on GHK as well, by itself, and it show basically the same results, as ghk bind to the copper thats already in your body n takes it were it needs to go. but as copper is so important the ghk cu must be superior
There is a doc doing podcast rounds right now explaining how copper toxticity is acually copper deficiancy. That we got to much un-bound toxic copper in tissue. I get estrogen issues with oral copper, just like females that got copper IUD, to much copper increase estrogen
But somehow it dident happen with injections, some even see reduced serum copper levels with ghk cu. makes me wounder about the copper toxticity/deficiancy thing
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@CrumblingCookie Also, the reason why the higher gkh cu dose the better (i would think) is that just taking 3-5mg ghk cu, its very little copper so its basically all ghks work
"Mass Calculation: Therefore, in a 5 mg total sample of GHK-Cu, the amount of copper corresponds to about 15-16% of that total mass."
"A 5 mg vial of GHK-Cu contains exactly 0.79 mg of pure copper."
Thats almost nothing. so its very surpricing people get so good results even with a dose as 5mg wich some feel is high, and just run 2-3mg
So in a 20mg dose
"A 20 mg vial of GHK-Cu contains exactly 3.15 mg of pure copper"
I personally notice zero collagen effects on 2mg oral copper, but on 4 i do. so having 3.15mg injected from a 20mg ghk cu dose that should def be superior to the 2-3mg ghk cu. So im not super surpriced that he had great effects
But as you said he was also using the kpv/tb500 glow stack wich all increase collagen, but my point is that a high dose copper should really do the work
Not saying that this dose is a must as so many people run low dose with good results, its just very interesting that he felt a super high dose + the other peps gave him so great results. as we still dont know wich dose of all of these therapies are the most effective
I would not be surpriced if it turns out we are microdosing alot of these therapies. Like we learnt with BPC, people were running 200mcg 15 years ago and now we know the MG doses are needed
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Well it will be interesting how it goes for you. With the EDS there's obviously been a greater collagen structure impairment and ensueing chronic infectious and inflammatory burden.
Are you nevertheless going to do a 4-weeks break after 8-10weeks of GHK-Cu to relieve downregulation pressure on integrin receptors?Would also be interesting whether "normal" GHK-Cu doses supplemented by more oral copper would already enhance its effects.
Someone was spamming all over reddit that the rate-limiting building block for mitochondrial biogenesis could be methyl groups. I doubt that. Obviously some amounts of phospholipids will be necessary. Beyond that perhaps it will require (supraphysiological) provisions of copper for it to reach there and make a therapeutic difference in contrast to the gradual, organic growth and development of tissues before adulthood. Most of the c. 100mg total body Cu may be localized within mitochondria if one does the math of Cu/mtProtein dry mass, with very little in the cytosol, serum and ECM.Like we learnt with BPC, people were running 200mcg 15 years ago and now we know the MG doses are needed
Haven't read about that anywhere either. AFAIK injected BPC plateaus at 500-1000mcg.
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uther peptides source is not a secret source and you can post their name. the ghkcu studied protocol is like 1mg or 10mg (honestly cant remember) per day for like 7-10 days once or twice a year maybe every quarter via a an insulin pump. one shot of 10mg a day is massively wasteful as it has 1/10th of the effectiveness to slam it all at once vs drip feed it throughout the day
tb500 is barely studied compared to tb4 and people perpetuate the naming mixup
bpc is active orally for systemic issues
small doses of various peptides incl bpc have been shown to work in animals when given frequently .
wa la
its 2026 and theres literally no reason to gatekeep these sources with private messages and secret chats
the ghk cu information on dosing by peptide enthusiasts is a testament to something or other about people because lorne pickharts work on it establishing doses is published in journals , its not secret information. the peptide mixes are just stuff someone made up, the doses make no sense but i guess it saves 8 seconds not having to draw from multiple vials
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@sunsunsun Thats not my source and there are tons of those wich the name you used, this post was for those that payed online prices and wanted cheaper
The info you have about vendors, you just learnt, you dident know about this few years ago. Even were i im in the bodybuilding comunity everyone pay regular price, very few buy kits. So good for you that you have a good vendor, most dont. Wich is why i made this thread
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Well it will be interesting how it goes for you. With the EDS there's obviously been a greater collagen structure impairment and ensueing chronic infectious and inflammatory burden.
Are you nevertheless going to do a 4-weeks break after 8-10weeks of GHK-Cu to relieve downregulation pressure on integrin receptors?Would also be interesting whether "normal" GHK-Cu doses supplemented by more oral copper would already enhance its effects.
Someone was spamming all over reddit that the rate-limiting building block for mitochondrial biogenesis could be methyl groups. I doubt that. Obviously some amounts of phospholipids will be necessary. Beyond that perhaps it will require (supraphysiological) provisions of copper for it to reach there and make a therapeutic difference in contrast to the gradual, organic growth and development of tissues before adulthood. Most of the c. 100mg total body Cu may be localized within mitochondria if one does the math of Cu/mtProtein dry mass, with very little in the cytosol, serum and ECM.Like we learnt with BPC, people were running 200mcg 15 years ago and now we know the MG doses are needed
Haven't read about that anywhere either. AFAIK injected BPC plateaus at 500-1000mcg.
The side effects people get fram ramping up mitochondria is always fixed by restoring methylation/adding more methyl donors. Sure more add ons are needed as well, dont know about copper like you said but many minerals like potassium (wich is a must for all the new cells being created) magnesium. as copper is so crucial for oxygen n mito it would def help but its not like methylation were you get sick if you dont ad it
Nope wont be doing any breaks. Havent really seen any evidence of downregulation when it comes to peptides, everyone that talk about doing breaks are doing it for how expencive the vials are, its copium
But its possible that it can happen. Seen a few saying mots c stopped working, and now for myself after starting it again i notice less of an effect vs few weeks back. GHK cu i feel right away tho and still do 3 months later
Running thymosine alpha 1 for autoimmune and still get the brain fog release n increase in energy
Were did you see that peptides caused downregulation?
Regarding BPC dosing changes its whats been learnt in the fitness industry the last decade. Know some clinics still recomend the 200-250mcg microdose but the 1mg works wayy better (according to those that used it for long). Belive i did 250mcg x 2 15 years ago but my inflammation issues were autoimmune/histamine driven so it did not help much
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@sunsunsun said:
the ghkcu studied protocol is like 1mg or 10mg (honestly cant remember) per day for like 7-10 days once or twice a year maybe every quarter via a an insulin pump. one shot of 10mg a day is massively wasteful as it has 1/10th of the effectiveness to slam it all at once vs drip feed it throughout the daytb500 is barely studied compared to tb4 and people perpetuate the naming mixup
bpc is active orally for systemic issues
small doses of various peptides incl bpc have been shown to work in animals when given frequently .
the ghk cu information on dosing by peptide enthusiasts is a testament to something or other about people because lorne pickharts work on it establishing doses is published in journals , its not secret information. the peptide mixes are just stuff someone made up, the doses make no sense but i guess it saves 8 seconds not having to draw from multiple vials
You are mixing up the epitalon protocol with ghk cu, 10mg for 10 days 2 times per year wich also makes no sense as the body needs constant repair
Either way, the half life of peptides dosent matter as they cause gene changes, GHK dosent need an insulin pump the genetic expression is changed for multiple days
Would it be better to dose it twize per day? possibly. but the gene expression will still be changed
Regarding tb4 vs tb5, the small fragment is barley sold its the full sequence that basically every vendor sell. wich also helps skin n other areas. i rather use the full sequence even if the fragment is possibly a little bit better. its the full that people got sucess stories with for the last 15 years
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Were did you see that peptides caused downregulation?
Only on GHK, here:
https://www.realpeptides.co/tolerance-ghk-cu-cosmetic-cycling-research-protocol/GHK cu i feel right away tho and still do 3 months later
I would really like to read how you respond to that megadosing of GHK-Cu in contrast to megadosing an equivalent mount of base GHK to get a feeling on how much is actually about GHK's direct actions and its copper shuttling versus the additionally supplied Cu. By switching to base GHK we sadly cannot infer anything about the former two but only the latter. If most of the extra effect is due to GHK's copper shuttling to where it's needed then extra melatonin and other oral compounds may replace or enhance that benefit.
Wondering about this also because even people with copper malabsorption disease only do about injectable 2mg (=.5mg elemental Cu) per day.
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