Dandruff or scalp irritation? Try BLOO.

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  • Scientific papers, books, blog posts. Discussion of whatever you find interesting and notable.

    715 Topics
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    AlphaZanceA
    It is intuitive to assume that double bonds make a molecule vulnerable to lipid peroxidation—after all, unsaturated fatty acids in cell membranes are the primary targets of oxidative damage. However, in tocotrienols, the unsaturated tail does not create this vulnerability because of where the antioxidant activity occurs and how its double bonds are structured. The Head Group (Chromanol Ring) Does the Antioxidant Work Vitamin E's capacity to halt lipid peroxidation resides entirely in its chromanol ring (the "head" of the molecule), not its hydrocarbon tail. A lipid peroxyl radical (LOO•) attacks cell membrane lipids. The phenolic hydroxyl group (-OH) on the chromanol ring donates a hydrogen atom to quench the radical: LOO• + Toc-OH -> LOOH + Toc-O• The resulting tocotrienoxyl radical (Toc-O•) is resonance-stabilized across the chromanol ring, rendering it too unreactive to continue the destructive oxidation chain reaction. Because hydrogen donation happens exclusively at the chromanol ring, the tail's saturation state does not alter the fundamental antioxidant mechanism. Isoprenoid Double Bonds vs. PUFA Double Bonds The main reason unsaturated fatty acids (PUFAs) like linoleic or arachidonic acid undergo rapid lipid peroxidation is the presence of bis-allylic methylene carbons—a single carbon with two hydrogen atoms situated directly between two double bonds (-CH=CH-CH2-CH=CH-). The C–H bond on a bis-allylic carbon is exceptionally weak, making it easy for free radicals to steal a hydrogen and trigger auto-oxidation. Tocotrienols do not have bis-allylic carbons: Their tail consists of isoprenoid units where double bonds are separated by two single bonds (-CH=C(CH3)-CH2-CH2-CH=C(CH3)-). Lacking bis-allylic hydrogens, the C–H bond strength in the tocotrienol tail remains high. Consequently, the isoprenoid tail is resistant to free radical abstraction under physiological conditions. The Unsaturated Tail Actually Improves Antioxidant Performance Rather than causing a conflict, the three double bonds in the isoprenoid tail give tocotrienols a significant biochemical advantage over saturated α-tocopherol: Superior Membrane Mobility: The double bonds introduce kinks that prevent tight packing within the phospholipid bilayer. This allows tocotrienols to rotate and laterally diffuse through membrane lipids up to 40 to 60 times faster than saturated tocopherols. Higher Collision Frequency: Because it moves much faster through the membrane, a single tocotrienol molecule collides with—and neutralizes—membrane lipid radicals far more frequently. Easier Recycling: The increased fluidity allows the chromanol head group to stay closer to the membrane-water interface, where cytosolic antioxidants (like Vitamin C and glutathione) can rapidly reduce the tocotrienoxyl radical back into its active antioxidant form. When we think of unsaturated fats going rancid (peroxidizing), we are usually thinking of Polyunsaturated Fatty Acids (PUFAs) like omega-3s or omega-6s. PUFAs contain "bis-allylic" methylene carbons—carbon atoms sitting directly between two cis-double bonds. The hydrogen atoms on these specific carbons are incredibly loosely bound and easily stolen by free radicals. In contrast, the unsaturated tail of a tocotrienol is an isoprenoid chain featuring trans-double bonds that lack these highly vulnerable bis-allylic positions. Therefore, the tail of a tocotrienol is chemically much more stable and resistant to free radical attacks than the membrane lipids it is trying to protect. Key Mechanisms in Liver Protection Tocotrienols target multiple pathways involved in liver cell damage and lipid accumulation: Mechanism Biological Target Clinical Outcome Antioxidant Action Quenches reactive oxygen species (ROS) in hepatocyte mitochondria Halts lipid peroxidation and protects cell membranes from oxidative damage. Lipid Regulation Downregulates HMG-CoA reductase (the rate-limiting enzyme in cholesterol synthesis) Helps suppress intrahepatic triglyceride synthesis and improve dyslipidemia. Anti-Inflammatory Suppresses NF-κB signaling and pro-inflammatory cytokines (TNF-α, IL-6) Reduces hepatic inflammation and attenuates progression to steatohepatitis. Anti-Fibrotic Inhibits hepatic stellate cell (HSC) activation Decreases collagen and extracellular matrix deposition, lowering liver stiffness. Clinical Evidence & Human Trials Clinical studies—primarily utilizing Bio-enhanced Palm Tocotrienol-Rich Fraction (TRF) or pure δ-tocotrienol—highlight several key therapeutic outcomes: Steatosis Remission: In double-blind, placebo-controlled trials of patients with ultrasound-proven fatty liver, 1 year of bio-enhanced tocotrienol supplementation led to a significant reduction in liver fat deposition, with up to 50% of treated individuals achieving full remission of MASLD/NAFLD. Reduction in Liver Stiffness: Transient elastography (FibroScan) measurements demonstrate that tocotrienols combined with lifestyle modifications reduce liver stiffness roughly 4 times more effectively than lifestyle modifications alone, indicating a slowing or reversal of early hepatic fibrosis. Enzyme & Biomarker Improvement: Supplementation consistently lowers elevated serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, along with reducing systemic markers of oxidative stress such as malondialdehyde. Support in Advanced Liver Failure: In patients with end-stage liver disease, tocotrienol complex administration showed positive trends in improving Model for End-Stage Liver Disease (MELD) scores compared to standard α-tocopherol. Dietary Sources & Bioavailability Tocotrienols occur naturally in specific plant matrices: Annatto seeds: Composed almost exclusively of δ-tocotrienols and γ-tocotrienols (tocopherol-free). Palm oil: Rich in a natural mix of α-, γ-, and δ-tocotrienols alongside α-tocopherol. Rice bran & Barley oil: Contain moderate concentrations of tocotrienol isomers. Because raw tocotrienols have variable intestinal absorption when taken on an empty stomach, clinical studies typically use bio-enhanced (self-emulsifying) formulations or advise taking supplements alongside fat-containing meals to optimize systemic bioavailability and hepatic uptake.
  • Websites, newsletters, articles, podcasts, interviews, explainers, books, and other resources that relate to the work of Dr. Raymond Peat.

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    Cancer Treatments – from Research to Application MCS Foundations for Life, In memory of my dear wife Mihaela Catalina Stanciu https://www.cancertreatmentsresearch.com/ https://jeffreydachmd.com/cancer-articles/
  • Do you have a question? You can post it here, but you will only receive unqualified personal opinions and NOT medical advice in any shape or form. If something seems like medical advice but it's posted in this category, it's actually a personal opinion.

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    @AnomPhen Thank you so much for your advice.I also think it's hypothyroidism, My mother was recently diagnosed with it and she's taking T4.
  • From medical devices to supplements. Red lights, CO2 tanks, large trash bags, kuinone, and more.

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    LejebocaL
    I managed to get the device before the price hike and with a bit of a discount. Now I use it daily. Still just for a few minutes at about 3% of CO₂. Noticed better sleep (remember dreams better and consistently get about 7 hours of sleep). Inhaling CO₂ also helped clear my migraine. (It was a mild, albeit annoying, case of migraine.) Here is an interesting paper on the CO₂ for migraines: STUDIES ON HEADACHE1. Effects of Carbon Dioxide—Oxygen Mixtures Given During Preheadache Phase of the Migraine Attack 2. Further Analysis of the Pain Mechanisms in Headache From the Summary and Conclusions section: A series of patients were given a 10 per cent carbon dioxide-90 per cent oxygen mixture by face mask during the preheadache or early headache phase. This mixture abolished the preheadache phenomena and aborted the headache in most of the trials. Ten per cent carbon dioxide in air was less effective, having a shorter and more transient effect.
  • Recipes, food, meal prep, brands. Discuss them all here.

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    MossyM
    @Jennifer You're welcome.  I can't help but reference these authors that have been such an influence on my me.  I stress again, I know everyone is different, in that the paths we've been on have us favoring different voices and styles, though I believe truth is truth, which survives above style and preference.  At the least, a truth discovered, even from an author who is not preferred, could lead us deeper into a subject, searching out an author we do prefer, who speaks to us better.  I do like archive.org.  I used to use them quite a bit, but then I got spoiled with how cheap some ebooks have become, and how the formatting allows for ease of use.  But, I will give this to the PDF format, you get the images of the original pages of books, which gives you some of that physical book quality, which can't be replicated in a full digital format.  I actually used to prefer the PDF for this reason, but now I can't resist the ease of full digital format.  Though, I will still go to archive.org for books not yet available as an ebook. Your religious history is very common, having touched upon various aspects of Faith through family, and educational institutions.  That's all of us, really; which is Lewis's story as well, until he became fully immersed. I do like the Alexandre brand very much.  I think there is hardly a better brand available for dairy, at least at a chain store.  Kalona is a good brand too, but like Alexandre, expensive.  Okay, so Nounos is cheaper, comparatively. So, you were basically making Greek yogurt from the regular versions, by straining it?  I never thought to do that, but can definitely see how that is costly. Yeah, stress is brutal on our health.  I can see how your mother's passing was hard.  Interesting, but kind of understandable, how plant-based foods were hard on your thyroid. When I was at my worst, raw foods were hard on me.  Maybe my correlation is off, but the strong natural defenses of plants, and especially with raw, seem the culprit.  Though, even as I type this, I remember raw juices made me feel good.  Maybe the juicing broke down those defenses.  This is my bro-science ...something worked by juicing them!  I have tried olive oil based D3.  A very lean version, with the only ingredient listed besides the D3 (cholecalciferol) being olive oil.  And strangely, I still had issues with it.  I've tried so many different versions. I forget which was the most temporarily tolerable — which is the only possible scenario for me.  I can take nothing long term, and I really can't remember a vitamin D supplement that didn't make me sick for at least a week...haha.  Funny stuff.  I may go back to putting mushrooms out in the sun, but there isn't really a way to know the true potency, though it would still be more than I'm getting.  Most of all, though, it would be costlier and more time consuming.  Maybe Haidut's is worth another try (if he has a non-ethanol version). Funny.  My only claim to being partially Italian is the claim itself (apart from my ancestors proving it): I don't think anyone would ever call me Italian by looking at me.  I like butter as well; even better than olive oil.  In most recipes, if I can use butter instead of oil, I'll do it.  But, right on cue, since I've started making banana bread, I've switched to coconut oil, and it is more moist.  From my limited experience, your mother is correct!  My understanding of olive oil is that you want a single source, cold pressed, and minimal time from harvesting, to manufacturing, to consumer.  This would eliminate, seemingly, as much potential for unwanted variables as possible.  It seems olive oil imported from outside the US is very subject to being something other than what is stated.  When I was researching this about a year or so ago, there were reports that the oils were not necessarily what was being claimed on the bottle, for non-US oils.  There were claims they were mixed (i.e., contaminated with lesser or other olive oils); and if not that, prolonged storage and transit was reducing the quality.  But, these days, who knows about the oils in the US.  My rule of thumb, is you do your best research, then just go with what you have have access to, and don't worry after that.  As for the 100% CA oil, it can be costly, but I only buy it on sale.  I normally use the Amazon brand, which is cheaper than the other popular, 100% CA brand (California Olive Ranch).  Olive oil is the one food item I consistently splurge on.  I splurge because of the potential rancidity of oils and other negative factors.  But, should my budget get even tighter, I'd simply buy a cheaper oil and not worry about it; though, always olive or coconut oil, not soy, canola, etc. It's worth adding, that even though the olive oil is a higher quality, it doesn't make the best tasting mayo, by itself. My understanding is that the blending breaks the fragile EVOO and makes it a bit bitter. I counter this by putting a little sugar in it.
  • Discussing pistol squats, concentric exercise, resting, and other forms of strength training.

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    T
    hello, im around 14% body fat as of now and im trying to get 10% or less, im on test so i dont really worry about it messing that up. what would be some effective methods of cutting to that low body fat without or with minimal caloric restriction. I keep my fat usually around 10% and i eat around 70% carbs, i usually only get my carbs from sugar although idk if its okay to have potatoes on a cut? i eat rn like 2500-2800 calories a day sometimes 3000 and im pretty much mantaining rn im 166cm and 64kg and high activity level supplements i take rn: thiamine vitamin d3 vitamin k2 glycine magnesium glycinate ive taken some info from a user here who goes by jameszb46 so im going to start doing this stack 400mg caffeine and 40mg clenbuterol a day and maybe add aspirin i have yet to start that but i will soon this week so yea im asking abt ways to cut without caloric restriction or minimal and how to boost my metabolic rate so after i cut i can mantain with lots of calories
  • DHT Source Discussion or PM For A Treat

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  • Dental question - Dr Ellie's Protocol

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    I applied her protocol when I suddenly started to have cavities in my front teeth and thinning of enamel. This came after years of no cavities at all, probably decades. I did not change anything else in my daily routine. After just a month 2 of my small cavities had completely disappeared and I did not get any new ones.
  • intresting chems source bounty

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    I was able to aquire fenclonine from a regular chemical supplier, same goes for all the other chemicals aswell. Its not hard you just have to jump through the hoops they give you and then they dont care.
  • B1 thiamine for memory

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    Does anyone know what type of B1 Peat recommended? HCL? He never seemed to specify.
  • There might be therapeutic benefits in increasing fat intake

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    @LucH said: I can develop if interested how I would manage. Yes I would be interested in your methodology...
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  • The Mysterious Case of Pufa Depletion

    pufa diet thyroid dnp
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    TexugoDoMelT
    @hcwilliams Ray recommended the slow approach. -Remove PUFAs from the diet -More carbs -Antilipolytics (B3, aspirin, etc.) -Other “saturators” (such as policosanol and perhaps the ones you mentioned) -T3 supplementation(which has a PUFA-depleting effect when you've already limited them in your diet) That way, you limited the PUFAs’ access to the mitochondria and could safely eliminate them through glucuronidation. The effect is the same as what I mentioned in one of my earlier comments. If a sample were taken, the tissues would have very low levels of PUFAs, so you could eliminate them in a controlled manner, which isn’t the case for most peaters, since losing fat isn’t really a concern for most of them. In that case, every time too much stored PUFAs were released, the situation would change. If someone has the patience to wait 4–6 years for that, I don't see why they shouldn't plan for gradual weight loss as well. You can easily lose 10–20 kg over that time without even worrying about it. Peaters madness
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    I bet you could get away with taking 1/10th of the recommended dose due to first pass bypass, similar to skin absorption id prefer skin application if the solubility wasn't so ass and required me tasting and smelling like dmso for hours
  • I never have a good sleep and I'm always tired during the day.

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    HEAR ME OUT AND OBEY. Gaze at the sky, the great blue sky. Never directly at the sun. Everyday. Initially it will strain your eyes. Dont overstress. Just do what you can do. It will regulate your biologic watch. Make your bedroom extremelly dark to get a restful sleep. Look for ways to rest and regenerate your eyes. Ex. Eating raw egg yolk makes my eyes less prone to light sensibility, eating salted raw carrot with little lemon improves guts health and lowers estrogen - great cause of eye health decay. "I will stay behind, to gaze at the sun. The sun is a wondrous body. Like a magnificent father! If only I could be so grossly incandescent!"
  • Ray Peat HATED manganese

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    @user1 To some degree, yes. The Orsense device measures hemoglobin via light sensors. When I have donated blood over the past 2 years, they have used this device to measure hemoglobin- https://www.youtube.com/watch?v=PkeD7ybugHk I don't know if you could tell much difference with the naked eye. Plus, if you see blood outside the body, it's going to be reacting with oxygen and clotting, both things that would make it darker and thicker. Also, while people with higher iron levels tend to have higher hemoglobin, it's a very rough guideline. People with certain types of anemias can even have high iron levels. And for most people, you can raise hemoglobin levels with a B complex. During de-ironing, I actually got hemoglobin to go up while ferritin was going down by using a B Complex and/or an iron free multivitamin with the same B Vitamins.
  • Silicon the dietary nutrient

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    LucHL
    @Hearthfire said: I think you get more silica/extract overall with ... What about the size of the silicon molecule to reach the cell, as if any " bio extract" from water, vegetable or bread could reach the target / the cell, at the same level !? No matter the state of your metabolism (> 55 yrs)
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    @sunsunsun said: apparently detection of viruses in ill people isnt really proof that this is causing the illness This is obviously true. You can observe all sorts of things on a sick person that probably have no effect on them being sick, like dandruff. Many sick people have dandruff, but is dandruff the cause of the illness? Even just sticking with microbes, it's obviously true. Both sick and healthy people have a gut biome, which is made up of several strains of bacteria, numbering into the trillions of individual cells. In any so called "viral" disease, the presence of trillions of bacteria in the gut are overlooked as a factor. Truthfully, even other "viruses" are neglected to be tested. As an example, when people were tested for the "Novel Corona Virus," they neglected to test for all the previous "Corona Viruses," as well as other "common cold and flu viruses." If you ran tests for 20 different "viruses" that are thought to cause cold and flu symptoms (and therefore, "Covid Symptoms" because there is a 100% overlap), and 7 came back positive, how could you claim that any single "virus" was responsible for the symptoms? It's actually worse than that, because EVERY "virus detection" test is actually a surrogate test. There is no way to directly test for ANY virus, not for the general public or in scientific studies. If there is no way to directly detect any virus, then how can you possibly create a remotely accurate surrogate test? Simply stated, there isn't, and in the case of Covid, the hundreds of millions of "asymptomatic patients" prove that. some people say covid isnt real, there's that tanksnowgood guy on rpf who constantly goes on about how there no such thing. when I got wuflu (I assume thats what it was) I got obscenely ill for 2 weeks and also experienced the weird sewage smell stuff and various other similar weird symptoms a lot of people describe. The claim that "covid isn't real" is really a claim that the alleged "Novel Corona Virus," aka SARS-Cov2 doesn't exist. Obviously, the symptoms people got when they got so called Covid are real. Things like coughing and fever can be easily observed in the real world. But the symptoms don't prove the cause. If you read the "Covid Isolation Reports," you can see that in truth, they never "isolated" anything. They took a sample from a sick person, along with all the potential other microbes, added to it a mixture of monkey kidney cells (aka, Vero cells), some antibiotics, some digestive enzymes like trypsin, Fetal Bovine serum, and cultured it in a medium that didn't provide adequate nutrients for cell survival. Then, when the cells showed signs of dying or breaking apart, they claimed that it was the result of an alleged "virus," and dismissed concepts like cell starvation, or the cell being poisoned by the antibiotics, or being ripped apart from the digestive enzymes. Since these "isolation tests" are the ONLY proof of a virus, the conclusion a lot of people have drawn is that SARS-Cov2 (and likely all other viruses) don't actually exist.
  • Anyone here diagnosed with POTS/MCAS/Dysautonomia?

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    LucHL
    @jd_au said: Keep it simple folks. Still fine for you. However, when taking HD B1, there is a protocol to follow. In short, there is interaction between several vitamins and trace elements. I then asked AI to help clarify the why and the how for other readers. AI says, as if LucH were speaking to JD: Glad it has lasted for you, JD! That is fantastic personal success, and it actually makes perfect sense given the specific combination you used. When you take thyroid hormone alongside thiamine, you are directly addressing the systemic metabolic bottleneck. In the bioenergetic framework Dr. Ray Peat talked about, low thyroid impairs the liver's ability to clear excess estrogen. High estrogen triggers nitric oxide, which over-relaxes (smoothes out) the blood vessels in the lower extremities, causing blood to pool and forcing the heart to beat faster to compensate (POTS). By taking thyroid and thiamine together, you restored cellular energy and vascular tone simultaneously, which is why your results have been so stable. However, for other readers looking to replicate this, it is crucial to understand why standalone High-Dose Thiamine (HD B1) protocols usually require cofactors. Skipping them can cause issues for the average person due to several factors: Magnesium is Mandatory: Thiamine cannot be converted into its active, usable form (thiamine pyrophosphate) without magnesium. Mega-dosing B1 alone rapidly depletes magnesium stores. This frequently triggers severe muscle cramps, anxiety, and heart palpitations, which people often mistake for a worsening of their POTS. The "Paradoxical Reaction": High doses of B1 can kickstart dormant mitochondrial pathways so suddenly that it causes a temporary, severe flare-up of autonomic symptoms. Adequate magnesium, potassium, and baseline nutrition help buffer this transition and prevent a metabolic shock. B-Complex Imbalance: Flooding the system with massive doses of a single B vitamin can eventually create a functional deficiency in other B vitamins (like B2 and B3) that share the same cellular energy pathways. In short, JD's success is a great example of the bioenergetic approach working perfectly because the underlying thyroid and estrogen pieces were addressed. But for most people starting a high-dose thiamine protocol on its own, skipping cofactors like magnesium is a frequent cause of metabolic stalls or severe symptom regressions. Keep it simple, but keep the underlying biochemistry in mind!
  • 5aDHP group buy - new source.

    5adhp
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    @Mauritio What effects did you notice from 3a-DHP and at what doses?
  • what compounds//chemicals do you think peat neglected?

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    @ThinPicking lol. 80s metal and 30s science
  • Diclofenac gel to regrow hair on bald head and beard

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    @Mossy areata though
  • Anything peaty for getting paperwork done?

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    MossyM
    @sunsunsun Indeed! Hence my need to call out my generalizing.
  • Epitestosterone, premature balding, and "male PCOS"

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    Has anyone tried well cooked mushrooms? There are many people reporting that it shifts the test/e2 ratio incredibly favorably, (better even than AIs). I hate to keep spamming Hans’ substack, but he’s run bloodwork pre-post mushroom experiments, and shown test/e2 rations above 20:1, (might have been 30:1 I don’t remember). Myself personally, (no bloodwork) but since I’ve added 3oz of well cooked mushrooms to each meal, I’ve seen nothing but improvement, (less puffy, zero constipation, reduction in inflammation, better mood etc).
  • Low Glutamate Diet

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    @user1 Thanks - I intuitively like maple syrup (manganese source). I eat it quite often in milk, and it may be somewhat calming. I like it.