@ridethelightning said:
I'll try supplementing with vitamin E and see what happens.
Here is some useful info:
AA cascade
If you want to take vitamin E against PUFA, Vit E is fine to stabilize membranes. We require at least 2 types, not necessary 50/50, e.g. 80 % alpha-tocopherol and 20% gamma. There are 4 types tocopherols and 4 types tocotrienols (alpha, beta, delta and gamma for each type).
Need gamma tocotrienols against inflammation. We shouldn't take alpha every day since the body has a higher affinity for alpha (transporter).
Chris Masterjohn says he takes 20-25 mg Vit E/day as supplement.
I take a higher level 400 UI but only twice a week (Now Foods, Advanced Gamma E complex, by iHerb). More is not better.
For stabilizing membranes, Vit E (20-25 mg suppl.), b-carotene (5-10 mg from food) and astaxanthine (only in cure) are fine to fight the AO aspect from both side (inside and outside the membrane).
Figure: How to protect membranes wit AO.
[image: 1783835485984-vit-e-amp-membrane-protection.png]
Remember:
Synergy effect with vitamin E
“Vitamin C regenerates vitamin E and vitamin E protects β-carotene, helped in this by polyphenols. In the event of β-carotene supplementation, vitamin C regenerates vitamin E and β-carotene, and β-carotene seems to protect vitamin E without really explaining this phenomenon "(1)
Savings effect
Vitamin E is not just a vitamin. Vitamin C makes it possible to recycle oxidized vitamin E and thus prolong its lifespan. The same goes with glutathione which is thus saved for other more useful functions (detox). Glutathion is our antioxidant master. Vitamin E protects against the deleterious effects of polyunsaturated fatty acids when the latter are in excess. And it is quickly done!
John Libbey Eurotext - Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions. Auteur : Claude Louis Léger.
*) Now sth else: AA cascade
If you think you suffer from too much PUFA, which is a widespread situation when we eat more than 5-6 grams PUFA’s a day. Most US individuals ingest 20 g PUFA every day when they eat manufactured food. So, yes there is a lot of arachidonic acid (AA) in their membranes.
And each time, someone is stressed – in the wide meaning – AA is unloaded.
The usual carburation passes from glycolysis to lipolysis when we run into a stressful event: adrenalin + cortisol make the usual carburation change. Moreover the body needs 90’ to recover the common one. Then bisglycinate magnesium 300 mg would be very useful (to take after, no anticipation). 2 or 3 times a day, Dr. JP Curtay says. Moreover we require 350-420 mg Mg element a day, for more than 300 enzymes.
*) Natural inhibitors against AA cascade
Here are some usual targets when suffering from inflammation.
Cox 1 & 2
5-Lox
IL-6
TNF-alpha
NF-kB
Excess NO
LPS
NB: Mind side-effects against platelet life and CYP450 enzymes (detox pathway). Only in cure when using phytotherapy.
See table here on my forum for details against inflammatory agents: Phytotherapy & natural agents for pain relief (In French).
https://mirzoune-ciboulette.forumactif.org/t266-substances-naturelles-anti-douleur-tableau#15733
*) Useful links (in French, translator needed):
https://mirzoune-ciboulette.forumactif.org/t642-vitamine-e-et-peroxydation-des-membranes#5645
https://mirzoune-ciboulette.forumactif.org/t1876-prostate-traitement-naturel-de-l-hyperplasie-benigne#26009
https://mirzoune-ciboulette.forumactif.org/t1042-activite-antioxydante-de-la-vitamine-e#10502 (required therapeutic needs round 50 mg or 100 UI per gram PUFA).
Excerpt:
Excessive intake of one type will limit the bioavailability and functionality of the others. While there is no established optimal composition, one can aim for a good balance within a blend as follows: alpha-tocopherol levels should not exceed a maximum of 15–20% of the total, with 50% or more consisting of gamma-tocopherols, 10% of tocotrienols, etc.
In other words: reduce alpha-tocopherol and significantly increase gamma- and delta-tocotrienols.