Studies showing cancer reversal / shrinking

Mauritio

I found some terpenes in this shop among them a-pinene and phytol. Not sure if they're food grade , but seems like it.

https://goldcoastterpenes.com/shop/terpene-isolates/alpha-pinene/

cs3000

@Mauritio good price thanks, i found some b-pinene which has similar effects in vitro (sometimes more potent than a-pinene sometimes not).
the positive (+) enantiomeric form of these might be more potent
b-pinene not a tumor study but used 200mg/kg orally in rats https://alz-journals.onlinelibrary.wiley.com/doi/pdf/10.1002/alz.076020

cs3000

starting after tumors already established
Lemon + Ginger created breast tumor regression
https://pmc.ncbi.nlm.nih.gov/articles/PMC9043650/
the treated group had much smaller tumor weight initially

wamidh talibs research on tumors with natural compounds over past 10 years with great results,

https://doi.org/10.1016/j.nut.2017.06.015 in this one lemon alone at higher dose 50mg/kg in mice (as extract, from dried fruit and peel) gave -83% reduction in tumor size (not reduction in growth, regression from initial size it shrunk that much, in 14 days

, all groups had similar initial tumor size, (controls showed 30% without tumors probably showing the initial tumor didnt establish in these)

cs3000

(important context for this 1)

60mg/kg succinate orally shrank liver tumors https://www.cell.com/iscience/fulltext/S2589-0042(24)02958-4

Succinate also decreased tumor incidence (3/6 mice in the succinate group vs. 6/6 mice in the PBS group, p < 0.01), tumor number (p < 0.01), and tumor load
, succinate also significantly suppressed the growth of subcutaneous PLC/PRF/5 xenografts (p < 0.01) and tumor weight

Vitamin E succinate didnt work well in ovarian https://pmc.ncbi.nlm.nih.gov/articles/PMC8176246/#sec11 can be high expression of SUCNR1 https://pmc.ncbi.nlm.nih.gov/articles/PMC7488939/ (but a dataset i saw showed similar between liver & ovarian?)

,

the context is SUCNR1 was low in the liver. So it only applies to tumors with low SUCNR1

Otherwise adding succinate / activating SUCNR1 more = increased metastasis

e.g lung cancer

In lung cancer, succinate derived from the cancer cells activates the SUCNR1 receptor and facilitates tumor metastasis through the PI3K/AKT pathway
However, data from The Cancer Genome Atlas (TCGA) indicate that SUCNR1 expression is considerably decreased in liver cancer, suggesting a distinct role for succinate in liver cancer.

Succinate binding to SUCNR1 activates several signaling targets, notably mitogen-activated protein kinases (MAPKs), and increases intracellular calcium and prostaglandin E2 (PGE2)
Succinate induced migration of LLC, A549, PC3, and HT-29 cells, which was blocked by antiSUCNR1 antibodies but not control IgG antibodies
. Furthermore, succinate induced invasion of LLC and HT-29 was similarly inhibited by SUCNR1 antibodies
succinate induces HIF-1a expression in a SUCNR1-dependent manner
Our results show for the first time that serum succinate concentrations are elevated in patients with lung cancer when compared to healthy subjects

succinate induces HIF-1a and il-6 in macrophages via SUCNR1

Kidney & lung especially high
https://v23.proteinatlas.org/ENSG00000198829-SUCNR1/pathology

regression result worked for liver specifically

alfredoolivas

@Mauritio yes, each product has 2 COAs. https://goldcoastterpenes.com/safety/

Mauritio

@alfredoolivas cool thanks

cs3000

A-pinene
200mg/kg mice dose but subcutaneously (orally would be metabolised different, caution needed tho there is a lethal dose)
just 2x a week

https://doi.org/10.1159/000479863

prostate cancer shrank , nearly went

one of the studies before using an essential oil 61% a-pinene worked given i.p , for melanoma at 600mg/kg not at 300mg/kg , mice
they used it 1 day on 1 day off
tolerated well enough with a day off between, for 2 weeks
no idea how that compares to oral absorption for this
In rats, orally All 3 animals in the high dose group [2000 mg/kg] died 24 hours after dosing. No mortalities occurred in the low dose animals [300 mg/kg] and no treatment-related effects were observed at necropsy.
idk how well translates to humans but (orally) in mice none died 2000mg/kg here acutely , and 400mg/kg of alpha or beta pinene was used for 2 weeks for seizures https://doi.org/10.1111/fcp.12416 (might see some liver damage taken daily though which is why i think they did 1 day on 1 day off in the other, showed liver protection). grams might not be tolerated well orally without causing the shits

Gardner

Youtube Video

Amazoniac

You can vary these terms for many relevant results:

metastasis "complete remission" metabolic | Google Scholar

Mauritio

I have ordered a-pinene and phytol from the above website. We'll see if it arrives since the whole process was kind of weird.

@cs3000 have you tried supplementing a/b-pinene?
It seems to have some interesting properties.
Maybe could be used as a cancer prevention.

Another possibility: use pinus cembra essential oil. It's ~40% a-pinene and ~10% b-pinene, with other terpenes like limonene making up the rest.
Theoretically it should be safe to ingest a drop of the essential oil, if diluted and organic. I haven't tried it yet, but can attest to its calming effects just from inhaling it.

In this study it increases life span just from inhaling it in flies under certain conditions.
https://www.nature.com/articles/srep28540