Posts made by LucH

I’m going to put some points in excerpt. I’ll develop if you are interested in.
Mind the following behavior: If you don’t agree now with one point, don’t throw away the baby with the bath-water. You may disagree but you have to say why if you want some help.
I’m not a nutritionist. I’m a teacher and I’m the administrator of a French site based on health and nutrition.
*) Former take of high dose thiamine HCL.
High dose Thiamine must be taken with some B2. Doses progressively raised. High dose thiamine has an impact on the detox pathway and histamine degradation (Cyp450 enzymatic pathway).
There is interaction between other B vitamins, especially B1 B2 B3 for glycemia. If you take B3 (niacinamide to avoid a flash reaction), you’ll need B6 + probably a methyl support (TMG) according to the type of B3. If you take B6, PLP mustn’t exceed a threshold, depending on the consumption by the body (low grade inflammation, immune reaction). Otherwise, you’ll get a problem with GABA-like symptoms (depravation) (a lack of / shortage due to a protection process of the brain: Too much of a good thing is bad).

B6 is needed / required for brain balance in the event of problems like you described. Vitamin B6 is well documented for its role as a modulator of steroid hormones: This vitamin contributes to the proper functioning of the nervous system. It participates in the synthesis of neurotransmitters, such as serotonin and dopamine, who play a crucial role in the regulation of mood, sleep and mental well-being.

But if you suffer from inflammation (low grade inflammation from bowel irritation or arthrosis if you are over 35 years old), your B6 will be burnt / exhausted.

Useful info (to read later)
-) English Corner – Vit B6: How much is too much?
https://mirzoune-ciboulette.forumactif.org/t2033-english-corner-vit-b6-how-much-is-too-much#29628
-) B6 modulates the activity of GABA. B6 as antioxidant and antipain.
https://mirzoune-ciboulette.forumactif.org/t2041-english-corner-b6-leads-to-decrease-of-cytokines-in-neuropathy#29659
-) English corner. Potential roles of Vit B6 in inflammation and immunity

@amizon said in High-dose thiamine troubleshooting:

my silly sensitive gut--and see if that can help my digestion and liver out,

Give details, please:
Dysbiosis (flatulence, gaz, bile, etc.). What about the MMC and the feces (2x/day)?

Need to follow a relaxation therapy, perhaps with supplements to optimize GABA (collagen, L-theanine,) + magnesium bisglycinate.
First soothing gut and stomach linings before eating carrot salad.
Need some glutamine too but not if dysbiosis.
Hope it will help.

@amizon said in High-dose thiamine troubleshooting:

Any suggestions would be much appreciated, thanks.

Hi, every body (1st post).
Too much thiamine could occasion issues related to histamine and acetylcholine excess that doesn’t make sense immediately. High level thiamine is a burden for the detox system CYP450.
Moreover we need some B2 after a while when taking B1 supplement. Mostlylurking has explained it very well. Thanks, by the way. B2 is not required every day.
And by the way, I read a post from redsun on RP forum (where I no longer go to), saying B6 could counteract symptoms brought by disorder from GABA and serotonin.
Mind the kind of B6. No pyridoxine (PNP). PLP must be taken with pause. I can explain how I did, if you want.

LucH