@eduardo-crispino said in Hair gel:

what oil

I use jojoba because it penetrate well and doesn't smell much. Can get it from 100 ml or 10 ml containers (bottle). From aroma-zone (France).

Hi,
I make my own gel (rather a soft gel) with aloe vera and "organic silicium" (G5).
To feed my hair, not as a gel. Fine.
1/3 water or flowered water (lavendula)
1/3 aloe
1/3 G5
30 ml oil
1 tsp solidifier
NB: Need to learn how to make a gel before testing.
Or there is a G5 gel but .why pay for a gel when I can make it (less expensive too).

Translation: Ever heard of the pendulum effect?

@eduardo-crispino said in Sativa marijuana is peaty:

there are marijuana strains from the tropical regions that grow differently and the effect is mostly mental. some have very little come down or tired-ness if any, and are more akin to a cup of coffee than a narcotic effect.

If you are conscious of this collateral effect ...

Marijuana THC alters brain synapses

There are more than 70 varieties of Cannabis sativa, of which the primary psychoactive component is THC (Δ9-tetrahydrocannabinol), at more or less high level. Using marijuana induces synaptic changes, when repeating the practice (e.g. usual smoking during the weekend).

*) Effects of Marijuana Use on Brain Structure and Function
THC appears to block synaptic plasticity and neurogenesis, particularly in hippocampal regions, which can have an effect on brain volume (Mato et al., 2004). THC has also been shown to interfere with mesolimbic dopamine pathway functioning (Bossong et al., 2008; Kolb, Gorny, Limebeer, & Parker, 2006).
Int Rev Neurobiol. 2016 Jul 20;129:33–65. doi: 10.1016/bs.irn.2016.06.004
Varieties of marijuana (Cannabis sativa) contain over 70 identified cannabinoids, of which the primary psychoactive component is THC (Δ9-tetrahydrocannabinol). The potential effects of THC on brain functioning are equally broad. THC exerts its effects on CB1 receptors are distributed broadly throughout the brain with particular areas of concentration in prefrontal, cerebellar, temporal, and hippocampal regions (Burns et al., 2007; Glass, Faull, & Dragunow, 1997; cf. Fig. 1B).
CB1 receptors = cannabinoid receptors type 1.
*) Synaptic changes induced by cannabinoid drugs and cannabis use disorder
In some regular cannabis users, CWS occurs after the cessation of cannabis use.
CWS = cannabis withdrawal syndrome.
https://doi.org/10.1016/j.nbd.2022.105670

"Zero fiber for gut irritation?"

=> I won't do that.
Need to know the difference between soluble fiber and insoluble fiber.
At the beginning it will be easier with soup and smoothie.
A combined approach is required:
How is the mucus of the stomach?
Do you digest well? Dysbiosis? Energy level?
Do you manage well with association in food?
How is the stress level?
And so on.
NB: Phytotherapy will be probably required to calm down et help support some kind of food.

Simplified version of the description for immune failing: pathophysiology key-points. Hypothetical disease model. (from Eduardo).
Only a partial analysis, just to avoid losing energy because the link is not fundamentally targeting SARS-CoV pathology but well how to remain in the low-symptom category when suffering from a compromised health issue. Not very readable …
Key points

1. Biofilms are protective and are under control of some bacterial fila to avoid inappropriate expansion.
2. If the microbiome has been compromised by a lack of protective species, pathogenic species could / are going to take the lead.
   => An ongoing slippery slope of microbiome dysbiosis is created by events which allow the surface area expansion of pathogenic biofilms.
3. These biofilms are degraded by helpful microorganisms, such as commensal various bacteria (Lactobacillus spp., Bifidobacterium spp., Bacillus spp. and other species), stomach acid, dietary intakes of biofilm degrading compounds and lifestyle choices.
4. Low populations of bifidobacterium are routinely found in chronic disease.
5. The protective microorganisms metabolize acetaldehyde into acetate, degrade biofilms and inhibit pathogenic species.
6. Antibiotics have broadly deleterious effects on microbiome diversity and abundance.
7. Acetaldehyde is well-known in chronic alcoholism for causing T-cell exhaustion, inhibiting glycolysis, decreasing NAD+/elevating NADH, inhibiting methylation, inhibiting collagen synthesis, dysregulating thiamine pyrophosphate metabolism and having a higher affinity for various aldehyde dehydrogenase (ALDH) isoenzymes required for eg. Neuro-transmitter degradation, histamine degradation and many other pathways.
   Gliotoxin, other mycotoxins and endotoxins are also relevant to this cascade.
8. Immune system dysregulation caused by malnutrition, low NK cell counts, medications that alter Interferon signaling bias / cascade regulation, antibiotics, bio-toxins, IFN-alpha promoting antigen dominance (eg. SARS-CoV-2 spike protein / infection, influenza, reactivated herpesviruses, isocitrate lyase expressing microorganisms, lipopolysaccharides, medical interventions which provide antigens for immune imprinting), and chronic stress (as elevated cortisol, dysregulation of cytokines) can each provide a window of opportunity for unimpeded biofilm growth, increased endo/mycotoxin production and net acetaldehyde increase.
9. Low grade inflammation: An inflammatory cascade is going to overcome and to create havoc.
10. Description of the hormone chaos.
    More details on this link from Eduardo (scroll till the bottom)
    https://bornfree.life/2024/

Covid long prevention
Kea ideas

1. Iodine supports the immune system and has immune-modulatory effects.
2. Iodine is well established as a broad-spectrum antimicrobial agent against bacterial, viral, fungal, and protozoan pathogens.
3. Targeting and blocking ACE2 receptors at the surface of the cell prevent SARS-CoV from infecting this cell.
4. There may be a U-shaped effect when taking HD D3 supplement. Note the supposition.
5. Vitamin K as a support for the integrity of membranes and platelet aggregation. Vitamin K status was reduced in patients with COVID-19 and related to poor prognosis.
6. Vitamin E is 100-fold more potent than usual anti-viral pro-drug advised.
7. Targeting minimum 35 ng/ml vitamin D3 as prevention middle.

*) Excerpt 1: Respiratory Infections
Iodine is well established as a broad-spectrum antimicrobial agent against bacterial, viral, fungal, and protozoan pathogens and has been used as an antiseptic for the prevention of wound infections for several decades. A 2021 article in the Ear, Nose & Throat Journal published an in vitro study by Pelletier et al. establishing that nasal and oral povidone-iodine (PVP-1) solutions are effective in inactivating SARS-CoV-2 at various concentrations after a 60-second exposure. They concluded that the tested formulations could help reduce SARS-CoV-2 transmission if used for nasal, oral, or surface decontamination in confirmed or suspected cases of COVID-19 (3). (…)
3. https://www.zrtlab.com/blog/archive/curious-about-iodine-part-3-antioxidant-immune-support-anti-cancer/#B8
To be continued on my forum (in French, translator needed, but with English references). Read it later, to be coherent and to spare energy

*) Excerpt 2: Quitting smoking will be protective.
Exposing the cells to smoke increased ACE2 by 42% by smokers.
From a talk between Chris Masterjohn & Ray Peat. ACE receptors seen by Ray Peat (mail from Chris Masterjohn)
Excerpt, from CM mail:
Since ACE2 is the entryway for SARS-CoV-2, it is the overwhelming determinant of infection, after exposure. As discussed in the new paper, this is supported by several lines of evidence:
• Blocking ACE2 with specific antibodies prevents SARS-CoV from infecting a cell.
• Cells that do not express ACE2 cannot be infected. However, experimentally inserting ACE2 into these cells allows them to be infected.
The amount of ACE2 on the cell surface will determine the number of viruses that can get into cells, and thus the rate at which the infection progresses, especially before the immune system starts to get it under control. Since viral load is a major determinant of the illness, more ACE2 will generally mean a more severe disease.
https://www.biorxiv.org/content/10.1101/2020.03.28.013672v1 (new paper link)

*) Excerpt 3: Losatran blocks the effects of ACE1 at its 'receptor'
ACE1 produces angiotensin, ACE2 inactivates the effects of ACE1 by breaking down angiotensin. The virus binds to the ACE2 and enters the cell through the Angiotensin 1 receptor. When the virus binds to the enzyme, it blocks ACE2's ability to deactivate angiotensin, so that ACE1 runs rampant producing angiotensin, and that matches with the effects we see in hospitalized patients.
Background (citing Chris Masterjohn).
ACE2 is an enzyme whose normal role in our physiology is to lower our blood pressure, and to prevent damage to tissues from fibrosis (laying down of scar tissue) and excess proliferation (cells reproducing at too high a rate, as occurs in tumors, for example).
SARS-CoV-2, the coronavirus that causes COVID-19, hijacks ACE2 on the cell surface in order to gain entry into the cell. All viruses must enter the cells of their host in order to hijack their protein-producing machinery, which they must do in order to replicate. No cell entry, no infection.
https://pubmed.ncbi.nlm.nih.gov/15165741/ (normal role link) (=> 2 x 50 mg Losartan).

Excerpt 4: U-form effect of vitamin D supplement
RealNeat, PhDr, speaking: “Since the SARS-CoV-1 virus has a gateway via ACE-2 (it binds to this ACE-2 receptor), it may be inappropriate in some cases (when already contaminated, note’s editor) to try to substantially increase vitamin D3 intake at all costs. D3 stimulates the production of ACE-2.
However, we know that vitamin D deficiency impairs cellular resistance (microbial peptides). Therefore, there may be a U-shaped effect. Too little vitamin D weakens people (immunity decreases). Excessive supplementation (> 2,000 IU) could have a counterproductive effect”.
End of RealNeat intervention
Chris Masterjohn estimates that a reasonable upper limit, based on what is likely needed to maintain 30 ng/mL (75 nmol/L) for most people, would be 1700 IU per day of vitamin D3.

Excerpt 4: Vitamin K as a support for the integrity of membranes and platelet aggregation
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome, though most of the patients have mild symptoms.
Severe extrahepatic vitamin K insufficiency has been demonstrated in Covid-19 patients by a significant proportion of patients suffering from a poor status in vitamin K. Optimizing vitamin K status is thus potentially a modifiable risk factor in corona disease if we want to maintain / activate matrix Gla protein (MGP) which protects against pulmonary and vascular elastic fiber damage.
Vitamin K metabolism can be seen as the potential missing link between lung damage and thromboembolism in Coronavirus disease 2019.
Sources and References
*) Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19
https://www.preprints.org/manuscript/202004.0457/v1
Vitamin K status was reduced in patients with COVID-19 and related to poor prognosis. Also, low vitamin K status seems to be associated with accelerated elastin degradation.
*) Dramatic Decrease of Vitamin K2 Subtype Menaquinone-7 in COVID-19 Patients
doi: 10.3390/antiox11071235 2022
The COVID-19 patients had significantly lower MK7 levels than non-COVID-19 pneumonia patients and healthy controls.
Conclusions: The present data identified significantly decreased vitamin K1, K2 (MK7), and increased MK4 levels in patients with COVID-19 compared to healthy controls. Vitamin K2 (MK7) was lowest in COVID-19 patients irrespective of potentially fatal courses, indicating consumption of this VK subtype by COVID-19 immanent effects, most probably inflammatory and oxidative stress factors.

To be continued on this link: “English corner: Long Covid Prevention”
https://mirzoune-ciboulette.forumactif.org/t2100-english-corner-covid-long-prevention#30146
*) Can red light therapy improve lung function?
*) Vitamin E is 100-fold more potent than Remdesivir against SARS-CoV-2 / corona viruses.
*) Appropriate Levels of Vitamin D3 Reduce Virus Risk by Half and Optimize Recovery.
Vitamins A and D are needed for:

• Antimicrobial peptides (AMPs). AMPs are small proteins that can disturb/disrupt microbial membranes, interfere with their metabolism, and damage cellular components.
• Lysozymes. Lysozymes are enzymes that damage bacterial cell walls by breaking down sugar bonds (bacterial LPS membranes).
• Iodine, the most effective halide for immune obliteration. When immune cells use phagocytosis against infections, they deplete the iodine contained in thyroid hormone.

*) Interaction between fat-soluble vitamins A D K

@BroJonas
If the liver is engulfed in fat, hé won't manage well. With glcemia problem there is not much to do.
Potassium from vegetable soup could help.
At night he could get low insuline, just to sleep well. But it won't solve anything. Thé problem will get More serious.

If he doesn't eat enough macronutrients (proteins) he'll loose muscles.
1.2 - 1.5 g protein x 75 kg weight.
=> collagen powder for half part.
Need a supplement with Vit B complex, Calcium phosphate 500 mg x 2, Vit K/D3, zinc 15 mg , Magnesium bisglycinate 2 g x 2, Vit C 500 mg x 2, vit E 25 mg, selenium 100 mcg 2x/wk.
iodine if he doesn't eat fish: 200 mcg kelp (tablet Now Foods).
But if he isn't convinced he assimilates rather less well, it will be OK Corral (war).
A shake with orange juice and supplements could do the job.

Edit: I won't force him. Inform him and see how he reacts. He'll need some time to accept the idea.
He'll need coconut oil for alternative fuel for the brain. begin with 2 tsp/d. Till 3 tbsp if he likes it (mix 1 tbsp in green soup).

@BroJonas said in Suggestions to help reverse severe sarcopenia in older type 2 diabetic:

Would love to hear some ideas on what we can do

Hi,
First I'd get informed: Read the book from Jessie Inaupsché to know how to manage food and understand why. But if your father doesn't want to change his habits, it will be useless.
Frighten him by telling him he'll get Alzheimer disease if he doesn't change.

Glucose Revolution Jessie Inaupsché

• Alarming results: In healthy individuals, a simple bowl of cereal propelled their glucose levels into a red zone that only diabetics were supposed to reach.
• Calories are not the determining factor in weight gain, all things considered. Understand that +500 K/cal should not be a problem if...
• Moderating the blood sugar peak leads to less oxidative stress, fewer free radicals, less inflammation.
• Walking 10 to 20 minutes after the evening meal reduces side effects.
• Your breakfast conditions your entire day in an unexpected way. Studies show that after a breakfast that causes a big spike in glucose, hunger returns more quickly and blood sugar remains out of control all day.
• The ideal order of foods: fiber – proteins (with fat) – carbohydrates. The fibers ingested first considerably reduce the glucose peak caused by sugar.
• Learn to understand the blood sugar curve, with examples.
  https://mirzoune-ciboulette.forumactif.org/t1925-glucose-revolution#26942
  (In French, with English links; translator needed)
  Site of Jessie Inaupsché:
  https://www.glucosegoddess.com

@ThinPicking said in “Long COVID” Suggestions:

your presence here is legendary to me.

Thanks for encouragement. Not too often, otherwise I could catch a big neck

As I was re-reading my notes to prepare a doc on useful molecules against covid,
I found this one:
Dramatic Decrease of Vitamin K2 Subtype Menaquinone-7 in COVID-19 Patients
doi: 10.3390/antiox11071235 2022
The COVID-19 patients had significantly lower MK7 levels than non-COVID-19 pneumonia patients and healthy controls.
Conclusions: The present data identified significantly decreased vitamin K1, K2 (MK7), and increased MK4 levels in patients with COVID-19 compared to healthy controls. Vitamin K2 (MK7) was lowest in COVID-19 patients irrespective of potentially fatal courses, indicating consumption of this VK subtype by COVID-19 immanent effects, most probably inflammatory and oxidative stress factors.
NB: I take K2 MK4 every day (1 drop 1 000 mcg) but once a week a high level of a mix, included 1200-1500 mcg K1 (1200 mcg) and KM7 (100 mcg)
Life Extension, Super K, 2600 µg,

And this one:
Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19
https://www.preprints.org/manuscript/202004.0457/v1
Vitamin K status was reduced in patients with COVID-19 and related to poor prognosis. Also, low vitamin K status seems to be associated with accelerated elastin degradation. An intervention trial is now needed to assess whether vitamin K administration improves outcome in patients with COVID-19.

Why?
Coagulopathy and thromboembolism are prevalent in severe COVID-19 and relate to decreased survival. Coagulation is an intricate balance between clot promoting and dissolving processes in which vitamin K plays a well-known role. We hypothesized that vitamin K status is reduced in patients with severe COVID-19.

@Kilgore said in How do I regain my Lactose Tolerance:

Drink 100ml of milk for 2 weeks, then double to 200ml for a week and you will be cured.

Well seen.
Most likely a temporary depletion of capacity, due to an imbalance between the production capacity of the lactase enzyme and the lactose intake from milk.
Logical evolution when we get older though some people can maintain the lactase production. No real explanation (for missing lactase) except when abstinent or defect. Not the case here, I think.

@DG said in How do I regain my Lactose Tolerance:

Bread and Pasta is no problem for my digestive system

Well, if you didn't dilute hydrochloric acid when eating meat (or legumes, rather particular to digest because of anti-protease enzymes), it's a problem of lactase.
No more than 100 - 150 ml liquid when eating proteins. pH problem for digestive enzymes.
And please, don't tell me you were able to do it before to justify it now. The abilities evolve. Context is all.

I cite:
Within the stomach, hydrochloric acid plays a major role in the breakdown of food, particularly proteins, and then in the assimilation of nutrients. It acidifies the food bolus to ensure the effectiveness of digestive enzymes.

@DG

We have a limited amount of lactase enzymes, variable for individuals.
To see whether it's a lactase defect, there is milk without lactose, for intolerant people.
It could be another reaction: Do you digest bread or pasta very well?
If not, you're intolerant to WGA (gluten). 50 % people intolerant to gluten are also intolerant to milk protein (casein). Similitude.
I won't force the body to accept what you aren't able to assimilate. Otherwise you'll get eager problems with the border bross (leaky gut). Then the addition will be much heavier!

@peatyRD said in “Long COVID” Suggestions:

If you subscribe to the idea of “long COVID”, what would your Peaty suggestions be in how to improve and ultimately resolve the condition?

Not specially peaty but here is an interesting talk on long convid.
I've more info on prevention and how to kill usual covid, if wanted. Don't let it come and remain too long.
I've had long covid but rather weak and manage to recup well.

Excerpt:
Nicotine for long covid
S.Holmes says:
Bioenergetic forum > Case studies
https://bioenergetic.forum/topic/3617/nicotine-for-long-covid
This is a very long video, but packed full of good information.
I've had covid 3 times which ultimately became long covid. My 84 year old mother had developed long covid at the same time. We both used the 7 mg nicotine patches for 7 days and our symptoms improved dramatically. Nicotine sounds like a wonder drug. I decided I'm going to stay on 3.5 mg throughout flu season.
https://rumble.com/v4obxnq-episode-04.10.2024-the-other-n-word.html

The_black_jew says:
@S.Holmes
It works but the acetylcholine stim can get overloaded which can cause nausea and a pretty horrific depression.
The human equivalent dose that stimulates nad+ is like 1-2mg over the course of an entire day.

S.Holmes says:
Good to know.
Dr. Ardis uses a 3 mg patch every day, and he said he will for the rest of his life. I wonder how he is able to do that without experiencing depression.
Thoughts?

The_black_jew:
@S.Holmes
3mg over a full day is probably totally fine.
I’m talking more about the 4mg 3x a day some people do.

ThinPicking:
It's conceivable any CNS stimulant would be effective in any fatigue syndrome of any kind.
This is pretty common in urban parts of Britain because life in them is so amusingly miserable.

@DavidPS said in Peat Approved Anti-Inflammatories?:

Caffeine: Found in coffee and chocolate, it has anti-inflammatory and liver-protective effects.

One example to say we should take the context into account.
Caffeine and coffee are fine, at least for 40 % people, as long you drink 3-5 cups (120 ml) a day.
Shortly said: Caffeine leaves metabolites that the liver is going to degrade / demethylate.
However, only 40 % people can manage it well (gene MTFR)

In adults, caffeine is almost completely metabolized in the liver by oxidation, demethylation, and acetylation. However, there are tiny genetic variations in 60% of individuals that can alter the breakdown of xanthines. In about 40% of the population, it is extremely efficient, so that caffeine is destroyed very quickly, before it causes side effects. Each person's sensitivity also depends on the number of caffeine receptors we have in our brain, which, again, depends on our genetics. Moreover, in people who drink coffee all day, the body protects itself by reducing the number of receptors, which reduces sensitivity to caffeine. Similar to a phenomenon of habituation. (1)
Caffeine is a methyl and is metabolized in the liver (CYP1A2 enzyme), then partially degraded. Caffeine is demethylated, then transformed into 3 primary metabolites: Paraxanthine (84%), theobromine (12%), and theophylline (4%). (2)
If you brake the way out of the kidneys by some molecules (e.g. polyphenols as coumarin from grapefruit juice or curcumin as anti-inflammatory, without making staples), it could exacerbate some side-effects you could have well managed if you had moderated the takes.

So, in short, no problem if you listen to your body signs and you manage it well.
I do appreciate coffee (espresso and perco) but I know I have to avoid habituation (4-5 hours between 2 cups), I have to take it easy from time to time when the anxiety level rises or when I suffer from excess histamine.
So finally, adapt and feel free to do it your own way. Moderate if you cumulate with oxalates and phytates. Caffeine could be considered as a friend or a foe, according to the context. (3)

References

1. https://nhco-nutrition.com/journal/pourquoi-la-cafeine-na-pas-le-meme-effet-chez-tout-le-monde/
   Source : Guide des compléments alimentaires pour sportifs, Michael Gundill et Frederic Delavier, Ed Vigot.
2. https://doi.org/10.1016/j.nutres.2020.05.005
   « Effets de la caféine sur le métabolisme systémique, les voies oxydatives-inflammatoires et les performances physiques ».
3. Caféine, ami ou ennemi ? (Friend or foe ?)
   http://mirzoune-ciboulette.forumactif.org/t1523-cafeine-ami-ou-ennemi#17789

@winters2 said in B vitamins are dangerous?:

I’ve been having health issues for quite some time now. So I’ve messed around with various supplements, especially the B vitamins. When taken orally,

You said you've already done this.

I understand what you say (metabolically compromised) but I don't agree with the way you want to proceed.
We don't give beef liver to a weak person (metabolically deficient). Too strong. Just to illustrate the situation. Not the right moment.
So, if you don't agree with my perception, I can admit it since you're better placed than me.
I loose my energy here. So I stop trying to convince you to stay away from supplements for a time, until the balance return in a soft mode, not overburdened.
Your liver can't manage what you bring. And moreover if there are deficiencies in getting rid of toxins, you have first to gain energy back before handling as you want to do it.

@winters2 said in B vitamins are dangerous?:

Could I possibly be deficient in Lipoic Acid?

Lipoic acid synthetase deficiency is a rare condition. It you had a "gene defect", you would have noticed it a long time ago.
So, I don't think you lack ALA. but ALA is useful in Hg chelation.
If you are aged over 50 - 60 and have old lead / mercury fillings, you could be deficient in methyl groups too. Nothing can function well if you eats a lot nuts (phytates) and don't vary your carb sources (sweet potato, potato in shirt) and eat a lot carrot salad ...

Anything with level 3 should be moderated (high level). Once OK, not as usual snack.
Before searching for deficiency, I 'd take first into account what prevents homeostasis to function.
First remove before adding. Too much of a good thing is bad.

@winters2 said in B vitamins are dangerous?:

I can read the link

See this post first ..
https://bioenergetic.forum/post/39136

@winters2 said in B vitamins are dangerous?:

@LucH

What did you mean about the B1? I thought you wanted no supplements

2 situations:

1. someone suffers from excess histamine (histaminose): A high level thiamine (HD B1) is counterproductive. HD B1 is all what is not required.
   Note there are interactions between several members of the group B complex.
2. As we can be sure of the source of the problem, we'd better stop all supplements and let homeostasis takes place.
   After 3-4 days, I'd take one supplement if, and only if, I've recovered from the immune reaction. First, I'd take magnesium. Not other one before 2 days (48H) separation.
   If you suffer from histaminose, you won't get rid of the problem in one week.
   I can give a link if you want to go deeper in the research about histamine.