@BroJonas
If the liver is engulfed in fat, hé won't manage well. With glcemia problem there is not much to do.
Potassium from vegetable soup could help.
At night he could get low insuline, just to sleep well. But it won't solve anything. Thé problem will get More serious.

If he doesn't eat enough macronutrients (proteins) he'll loose muscles.
1.2 - 1.5 g protein x 75 kg weight.
=> collagen powder for half part.
Need a supplement with Vit B complex, Calcium phosphate 500 mg x 2, Vit K/D3, zinc 15 mg , Magnesium bisglycinate 2 g x 2, Vit C 500 mg x 2, vit E 25 mg, selenium 100 mcg 2x/wk.
iodine if he doesn't eat fish: 200 mcg kelp (tablet Now Foods).
But if he isn't convinced he assimilates rather less well, it will be OK Corral (war).
A shake with orange juice and supplements could do the job.

Edit: I won't force him. Inform him and see how he reacts. He'll need some time to accept the idea.
He'll need coconut oil for alternative fuel for the brain. begin with 2 tsp/d. Till 3 tbsp if he likes it (mix 1 tbsp in green soup).

@BroJonas said in Suggestions to help reverse severe sarcopenia in older type 2 diabetic:

Would love to hear some ideas on what we can do

Hi,
First I'd get informed: Read the book from Jessie Inaupsché to know how to manage food and understand why. But if your father doesn't want to change his habits, it will be useless.
Frighten him by telling him he'll get Alzheimer disease if he doesn't change.

Glucose Revolution Jessie Inaupsché

• Alarming results: In healthy individuals, a simple bowl of cereal propelled their glucose levels into a red zone that only diabetics were supposed to reach.
• Calories are not the determining factor in weight gain, all things considered. Understand that +500 K/cal should not be a problem if...
• Moderating the blood sugar peak leads to less oxidative stress, fewer free radicals, less inflammation.
• Walking 10 to 20 minutes after the evening meal reduces side effects.
• Your breakfast conditions your entire day in an unexpected way. Studies show that after a breakfast that causes a big spike in glucose, hunger returns more quickly and blood sugar remains out of control all day.
• The ideal order of foods: fiber – proteins (with fat) – carbohydrates. The fibers ingested first considerably reduce the glucose peak caused by sugar.
• Learn to understand the blood sugar curve, with examples.
  https://mirzoune-ciboulette.forumactif.org/t1925-glucose-revolution#26942
  (In French, with English links; translator needed)
  Site of Jessie Inaupsché:
  https://www.glucosegoddess.com

@ThinPicking said in “Long COVID” Suggestions:

your presence here is legendary to me.

Thanks for encouragement. Not too often, otherwise I could catch a big neck

As I was re-reading my notes to prepare a doc on useful molecules against covid,
I found this one:
Dramatic Decrease of Vitamin K2 Subtype Menaquinone-7 in COVID-19 Patients
doi: 10.3390/antiox11071235 2022
The COVID-19 patients had significantly lower MK7 levels than non-COVID-19 pneumonia patients and healthy controls.
Conclusions: The present data identified significantly decreased vitamin K1, K2 (MK7), and increased MK4 levels in patients with COVID-19 compared to healthy controls. Vitamin K2 (MK7) was lowest in COVID-19 patients irrespective of potentially fatal courses, indicating consumption of this VK subtype by COVID-19 immanent effects, most probably inflammatory and oxidative stress factors.
NB: I take K2 MK4 every day (1 drop 1 000 mcg) but once a week a high level of a mix, included 1200-1500 mcg K1 (1200 mcg) and KM7 (100 mcg)
Life Extension, Super K, 2600 µg,

And this one:
Reduced Vitamin K Status as A Potentially Modifiable Prognostic Risk Factor in COVID-19
https://www.preprints.org/manuscript/202004.0457/v1
Vitamin K status was reduced in patients with COVID-19 and related to poor prognosis. Also, low vitamin K status seems to be associated with accelerated elastin degradation. An intervention trial is now needed to assess whether vitamin K administration improves outcome in patients with COVID-19.

Why?
Coagulopathy and thromboembolism are prevalent in severe COVID-19 and relate to decreased survival. Coagulation is an intricate balance between clot promoting and dissolving processes in which vitamin K plays a well-known role. We hypothesized that vitamin K status is reduced in patients with severe COVID-19.

@Kilgore said in How do I regain my Lactose Tolerance:

Drink 100ml of milk for 2 weeks, then double to 200ml for a week and you will be cured.

Well seen.
Most likely a temporary depletion of capacity, due to an imbalance between the production capacity of the lactase enzyme and the lactose intake from milk.
Logical evolution when we get older though some people can maintain the lactase production. No real explanation (for missing lactase) except when abstinent or defect. Not the case here, I think.

@DG said in How do I regain my Lactose Tolerance:

Bread and Pasta is no problem for my digestive system

Well, if you didn't dilute hydrochloric acid when eating meat (or legumes, rather particular to digest because of anti-protease enzymes), it's a problem of lactase.
No more than 100 - 150 ml liquid when eating proteins. pH problem for digestive enzymes.
And please, don't tell me you were able to do it before to justify it now. The abilities evolve. Context is all.

I cite:
Within the stomach, hydrochloric acid plays a major role in the breakdown of food, particularly proteins, and then in the assimilation of nutrients. It acidifies the food bolus to ensure the effectiveness of digestive enzymes.

@DG

We have a limited amount of lactase enzymes, variable for individuals.
To see whether it's a lactase defect, there is milk without lactose, for intolerant people.
It could be another reaction: Do you digest bread or pasta very well?
If not, you're intolerant to WGA (gluten). 50 % people intolerant to gluten are also intolerant to milk protein (casein). Similitude.
I won't force the body to accept what you aren't able to assimilate. Otherwise you'll get eager problems with the border bross (leaky gut). Then the addition will be much heavier!

@peatyRD said in “Long COVID” Suggestions:

If you subscribe to the idea of “long COVID”, what would your Peaty suggestions be in how to improve and ultimately resolve the condition?

Not specially peaty but here is an interesting talk on long convid.
I've more info on prevention and how to kill usual covid, if wanted. Don't let it come and remain too long.
I've had long covid but rather weak and manage to recup well.

Excerpt:
Nicotine for long covid
S.Holmes says:
Bioenergetic forum > Case studies
https://bioenergetic.forum/topic/3617/nicotine-for-long-covid
This is a very long video, but packed full of good information.
I've had covid 3 times which ultimately became long covid. My 84 year old mother had developed long covid at the same time. We both used the 7 mg nicotine patches for 7 days and our symptoms improved dramatically. Nicotine sounds like a wonder drug. I decided I'm going to stay on 3.5 mg throughout flu season.
https://rumble.com/v4obxnq-episode-04.10.2024-the-other-n-word.html

The_black_jew says:
@S.Holmes
It works but the acetylcholine stim can get overloaded which can cause nausea and a pretty horrific depression.
The human equivalent dose that stimulates nad+ is like 1-2mg over the course of an entire day.

S.Holmes says:
Good to know.
Dr. Ardis uses a 3 mg patch every day, and he said he will for the rest of his life. I wonder how he is able to do that without experiencing depression.
Thoughts?

The_black_jew:
@S.Holmes
3mg over a full day is probably totally fine.
I’m talking more about the 4mg 3x a day some people do.

ThinPicking:
It's conceivable any CNS stimulant would be effective in any fatigue syndrome of any kind.
This is pretty common in urban parts of Britain because life in them is so amusingly miserable.

@DavidPS said in Peat Approved Anti-Inflammatories?:

Caffeine: Found in coffee and chocolate, it has anti-inflammatory and liver-protective effects.

One example to say we should take the context into account.
Caffeine and coffee are fine, at least for 40 % people, as long you drink 3-5 cups (120 ml) a day.
Shortly said: Caffeine leaves metabolites that the liver is going to degrade / demethylate.
However, only 40 % people can manage it well (gene MTFR)

In adults, caffeine is almost completely metabolized in the liver by oxidation, demethylation, and acetylation. However, there are tiny genetic variations in 60% of individuals that can alter the breakdown of xanthines. In about 40% of the population, it is extremely efficient, so that caffeine is destroyed very quickly, before it causes side effects. Each person's sensitivity also depends on the number of caffeine receptors we have in our brain, which, again, depends on our genetics. Moreover, in people who drink coffee all day, the body protects itself by reducing the number of receptors, which reduces sensitivity to caffeine. Similar to a phenomenon of habituation. (1)
Caffeine is a methyl and is metabolized in the liver (CYP1A2 enzyme), then partially degraded. Caffeine is demethylated, then transformed into 3 primary metabolites: Paraxanthine (84%), theobromine (12%), and theophylline (4%). (2)
If you brake the way out of the kidneys by some molecules (e.g. polyphenols as coumarin from grapefruit juice or curcumin as anti-inflammatory, without making staples), it could exacerbate some side-effects you could have well managed if you had moderated the takes.

So, in short, no problem if you listen to your body signs and you manage it well.
I do appreciate coffee (espresso and perco) but I know I have to avoid habituation (4-5 hours between 2 cups), I have to take it easy from time to time when the anxiety level rises or when I suffer from excess histamine.
So finally, adapt and feel free to do it your own way. Moderate if you cumulate with oxalates and phytates. Caffeine could be considered as a friend or a foe, according to the context. (3)

References

1. https://nhco-nutrition.com/journal/pourquoi-la-cafeine-na-pas-le-meme-effet-chez-tout-le-monde/
   Source : Guide des compléments alimentaires pour sportifs, Michael Gundill et Frederic Delavier, Ed Vigot.
2. https://doi.org/10.1016/j.nutres.2020.05.005
   « Effets de la caféine sur le métabolisme systémique, les voies oxydatives-inflammatoires et les performances physiques ».
3. Caféine, ami ou ennemi ? (Friend or foe ?)
   http://mirzoune-ciboulette.forumactif.org/t1523-cafeine-ami-ou-ennemi#17789

@winters2 said in B vitamins are dangerous?:

I’ve been having health issues for quite some time now. So I’ve messed around with various supplements, especially the B vitamins. When taken orally,

You said you've already done this.

I understand what you say (metabolically compromised) but I don't agree with the way you want to proceed.
We don't give beef liver to a weak person (metabolically deficient). Too strong. Just to illustrate the situation. Not the right moment.
So, if you don't agree with my perception, I can admit it since you're better placed than me.
I loose my energy here. So I stop trying to convince you to stay away from supplements for a time, until the balance return in a soft mode, not overburdened.
Your liver can't manage what you bring. And moreover if there are deficiencies in getting rid of toxins, you have first to gain energy back before handling as you want to do it.

@winters2 said in B vitamins are dangerous?:

Could I possibly be deficient in Lipoic Acid?

Lipoic acid synthetase deficiency is a rare condition. It you had a "gene defect", you would have noticed it a long time ago.
So, I don't think you lack ALA. but ALA is useful in Hg chelation.
If you are aged over 50 - 60 and have old lead / mercury fillings, you could be deficient in methyl groups too. Nothing can function well if you eats a lot nuts (phytates) and don't vary your carb sources (sweet potato, potato in shirt) and eat a lot carrot salad ...

Anything with level 3 should be moderated (high level). Once OK, not as usual snack.
Before searching for deficiency, I 'd take first into account what prevents homeostasis to function.
First remove before adding. Too much of a good thing is bad.

@winters2 said in B vitamins are dangerous?:

I can read the link

See this post first ..
https://bioenergetic.forum/post/39136

@winters2 said in B vitamins are dangerous?:

@LucH

What did you mean about the B1? I thought you wanted no supplements

2 situations:

1. someone suffers from excess histamine (histaminose): A high level thiamine (HD B1) is counterproductive. HD B1 is all what is not required.
   Note there are interactions between several members of the group B complex.
2. As we can be sure of the source of the problem, we'd better stop all supplements and let homeostasis takes place.
   After 3-4 days, I'd take one supplement if, and only if, I've recovered from the immune reaction. First, I'd take magnesium. Not other one before 2 days (48H) separation.
   If you suffer from histaminose, you won't get rid of the problem in one week.
   I can give a link if you want to go deeper in the research about histamine.
   

@winters2
Looks like histaminose. Mind HD B1. Not required.
I"d stop all suppléments for one week.
Get informed on DAO enzyme and how to manage histamine.

@winters2 said in B vitamins are dangerous?:

now I have some kind of neuropathy issue and my wrist is a bit uncomfortable because of this.

How much B6 did you take and what kind (PNP or PLP)?

@16charactersitis said in Peat Approved Anti-Inflammatories?:

sugar, aspirin, progesterone, lidocaine and food sources of magnesium and calcium, eg, eggs, dairy, coffee and leafy greens (eg spinach)

OK but it needs to be modulated. Listen to your body!
Sugar as long it comes with fiber, 50/50 glucose / fructose, it doesn't stimulate insulin too high, comes with cofactors to burn well...
Not everybody is able to burn a high level sugar when drinking 200 ml (7 oz) OJ after cereals and 240 ml milk (8.5 oz.). Limit OJ to 100 ml (3.5 oz.) if your BMI is over 25. and don't eat a yaourt as dessert. Take it apart (collation).

Calcium as long you target it well. Too low and it will excite PTH, too high (what we don't need) and it will unbalance Ca/ Mg ratio. Ca only from food or it will prevent us from assimilating Zn Fe Cu (same transport).
10-20 % people suffer from a high level of intolerance to WGA (gluten) and need to recover during the night. Already heard from cross-reaction? 50 % people intolerant to wga also suffer from casein intolerance (80 % milk proteins). Not every body has the capacity to digest a high level of lactose (amount of lactase enzyme limited).

RP is right but it must be contextualized, as long you listen to your body reaction.

And by the way, not everybody can get A2 milk, directly from the farmer. A1 and A2 milk contain different types of beta-casein protein.

Eggs as long you balance leucine with glycine (from beef cuts or bone both e.g.). Leucine stimulates growth. A full spectrum of amino acids is required to avoid cell anarchy (cancer).
2 to 3 times a week to avoid leucocytose. If you overdrive, it will give histaminose, a stress reaction.

Leafy greens as long your vary. Fine, so. Spinach is very high in oxalate (660 mg). I don't take spinach without eating cheese.
4/1 ratio Ca / Ox is fine. 4/3 if not every day and you didn't already get problems with lithiasis.
Or bring potassium citrate (Mg bisglycinate 2.5 g is fine too) to amalgam excess oxalate. Lithiasis prevention (kidney stones). RDA is 50 mg Ox. Do not take more 150-200 mg oxalate (highest level) without "diluting" it, on a repeated way. 1200 mg Ca/d will mostly do the job well, when eating spinach or rhubarb, for most people, if you vary well.

@LetTheRedeemed said in Peat Approved Anti-Inflammatories?:

any anti-inflammatory substances

CO2
useful info on the link
Oral NaHCO3, M2 macrophages, Carbon dioxide and inflammation
https://mirzoune-ciboulette.forumactif.org/t2050-english-corner-oral-nahco3-m2-macrophages-carbon-dioxide-and-inflammation#29755
Target points

• Understanding the action of bicarbonate (NaHCO3) on inflammation and immune system (1)
• Interaction of macrophages with the redox signals, reprogramming the environment in health and disease: Redox Control of Inflammation by Macrophages (sensing mechanisms), induced by NaHCO3 (2-3)
• Protective effects of CO2 on immunosuppressive system, mediated by the splenic nerve (new anti-inflammatory pathway), with the help of the chemical messenger acetylcholine (4)
• Carbon dioxide has antioxidant effects, and many other stabilizing actions. (5)

@LetTheRedeemed said in Peat Approved Anti-Inflammatories?:

definitely need vit K with it!!

Yes, exactyly what I do.
one drop K2 MK4 ( 1 mg / 1 000 mcg) every day at breakfast (it needs a lot of fat (3 levels for optimizing: 14 - 25 - 36 g fat).
And once a week a mix with K1 1200 - 1500 mcg.

@LetTheRedeemed said in Peat Approved Anti-Inflammatories?:

could you share any anti-inflammatory substances Peat has suggested? Thanks!

Aspirin but do not take it on continuous take as it has an impact on platelet aggregation.

@thyroidchor27 said in Iodine as a game changer:

Iodine works well in the winter for boosting thermogenesis but I think in the summer its not really needed.

what about the other parameters?
If you feel / perceive cold hands or feet only in the winter, there are probably other symptoms of low metabolism you're accustomed and therefore think it's normal, or at least you manage with ... Until when !?
And it's not because you don't perceive it yet (under the radar), there aren't any low-grade problems ...

https://www.news-medical.net/news/20240321/Exploring-the-role-of-iodine-in-obesity-diabetes-and-other-metabolic-conditions.aspx
=> The correlation between iodine and metabolism: a review.
Excerpt
Mechanisms underlying the metabolic effects of iodine
Iodine exerts antioxidative, antimicrobial, immunomodulatory, and molecular regulatory effects. Iodine alters the proportion of pathogenic and beneficial bacteria to restore the gut microbiome and reduce insulin resistance, obesity, and metabolic syndrome parameters.
Iodine also reduces inflammation by lowering oxidative and endoplasmic reticulum stress caused by free radicals such as reactive oxygen species (ROS).
Iodine acts on the Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) pathway to enhance the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (Cat), and glutathione peroxidase (GSH-Px).
In addition, iodine alters inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX2) levels, regulating mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) pathways to reduce chronic inflammation and improve metabolic health.
The mineral acts on type 2 deiodinase (D2) receptors that convert T4 to biologically active T3 to improve weight management and adaptive thermogenesis.
Iodine also interacts with peroxisome proliferator-activated receptor-γ (PPARγ) receptors to enhance adipocyte differentiation, fatty acid uptake, and glucose metabolism ...
Source: The correlation between iodine and metabolism: a review.
2024 | https://doi.org/10.3389/fnut.2024.1346452