@Ray-Peat-Fanboy said in What do you guys think about Linus Pauling and Vitamin C?:

Should I buy Thornes Vitamin K? And what brand do you recommend for a vitamin E supplement?

For vit E, 20-25 mg is required, but 100 mg after 40ies. Must be at least 2 tocos.
I take 2x/wk 400 UI. Mind this: too much of a good thing is bad.
Now foods - Advanced gamma E complex 120 caps.

For Vit K:

• once a Wk Life Extension super K (all forms of vit K, high dose)
• 1 drop Thornes Vitamin K2 MK4 (1 000 mcg) every day. Must be taken with high dose fat. 35 g optimal.
  Avoid if under 24 g fat. Postpose.
• At midday, I take 5000 UI vit D (from November till April) (winter time).
  For details about posology , how and why, I can give a link if desired.

@Ray-Peat-Fanboy said in What do you guys think about Linus Pauling and Vitamin C?:

I was thinking about taking high dose vitamin C for anti stress purposes.

Well, looking at the study, the main points are:

• 1 g AA/day.
• Less cortisol secreted.
  No explanation.

We know AA (ascorbic acid) has antioxidant effects and other positive side-effects on inflammation pathways.
Remind that AA must be from guaranteed source (no heavy metals). If you don’t want rubbish one (not effective), N° CAS 50-81-7 and / or optical rotation 20.5-21.5 °.
Split the dose 1 g in 3x (half-life).
So, yes AA plays a role on stress. But you could do the same with L-theanine and collagen (glycine has gaba-like effects). + a technic to lower tension like EFT, deep breath and walking.
And if you really want to protect the heart, it’s rather in the direction of arteries you should look at. Protect membranes vessels with liposoluble vitamins, especially Vit K2.
Useful info (in French, translator needed):
Vitamine E et peroxydation des membranes
https://mirzoune-ciboulette.forumactif.org/t642-vitamine-e-et-peroxydation-des-membranes#5648
Interaction entre les vitamines A D K
Calcium regulation and thyroid inquiry
https://bioenergetic.forum/topic/2275/calcium-regulation-and-thyroid-inquiry

Hi,
I won't say so. Useful explanations as an encyclopedia could be.
Put some point in excerpt if you want to debate (and give a link if possible) ...

@Luke said in Cheap peaty fruit suggestions:

I don't know whether citrate has any benefits over carbonate (other than the increased bioavailability), but if you mix carbonate into orange juice, it should react with the citric acid in the juice to form calcium citrate.

Yes, I confirm:
What happens when citric acid reacts with calcium carbonate?
3CaCO3 + 2H3C6H5O7 -> Ca3(C6H5O7)2 + 3H2O + 3CO2
When calcium carbonate (CaCO3) reacts with citric acid C6H8O7, calcium citrate is formed Ca3(C6H5O7)2 + water (H2O) and Gas (CO2) (carbonic gas). It is an acid-base reaction.
If you put calcium carbonate or calcium citrate in fruit juice, it’s going to become fizzy. The production of carbon dioxide gas typically results in bubbling or fizzing during the reaction.
It can also be called a chelated reaction since an insoluble salt of calcium (calcium carbonate) is converted into a more soluble one (calcium citrate). Calcium citrate is rather a water-soluble salt.

Comment:
How much citrate?
It depends on the ratio acid citric and carbonate. I don't know precisely but the effect is no quite immediate. Lightly delayed. Not a good idea if your eat pasta / bread / flakes 3 times a day since WGA agglutins (from wheat) are opening the tight junctions of the intestinal border brush.
Here I make an analogy with magnesium supplement when suffering from leaky gut. Not the right time to take Mg supplement during a meal with oxalates when tight junctions are not very tight. Too long / difficult too explain why.
However, the organism is repairing itself during the night. Theoretically, if we don't abuse regularly.
NB: other benefit:
Magnesium citrate or potassium citrate capture / solubilize CaOx on a much easier way (100x more easier than calcium citrate salts). Once you've suffered from lithiasis (kidney stone, but not only in kidneys), you'll take it quickly into account.

guy said in Cheap peaty fruit suggestions:

Question: I have a big bag of magnesium carbonate, is it still effective at helping calcium absorption? Should I just switch to mag bisglycinate immediately?

Keep it and alternate. But if sleep and mood are targeted, it is worth changing for bisglycinate.
Carbonate before sleep is useless since it needs food.

@guy said in Cheap peaty fruit suggestions:

maybe I should up the mag as well?

Well, if it Mg bisglycinate, it would be fine. Why?

• impact on brain (gaba-like effects): restful / relaxing. 2.5 g Mg bisglycinate is my dose, often split in 2 takes. Best with meal but OK if alone.
• one of the 2 or 3 best forms. I can give a link if needed.
  keep in mind that there is interaction between P and Mg.
  As already mentioned:
  Optimal ratio for P / Ca according to RP is 1 / 2.2 (like in milk). Never go occasionally above twice more phosphate.

@guy said in Cheap peaty fruit suggestions:

I've been supplementing calcium carbonate the past few days with good results - I find digesting large amounts of milk difficult.

Logical for milk: lack of lactase enzyme. The same for a lot of people. And we're not talking about intolerant ones because of a cross-reaction with WGA (agglutin from wheat).

Comments:
When your Ca carbonate supplement has been consumed, I’d take citrate.
Why?

• No need to take it with foodstuff.
• Especially useful to capture / amalgamate oxalate (lithiasis / kidney stones).
  => Proportion 1/3 Ca citrate: if 600 mg Ox, 200 mg Ca.

NB: Calcium citrate is readily more absorbed than Ca carbonate: 33 % on average in the study below, provided you moderate the amount (150-250 Ca element) (1)

Magnesium keeps calcium dissolved in the blood (100 x less aggregated with Mg or K than with Ca). (2-3)

Sources & References

1. Calcium absorption from all sources was estimated to be about 30 %.
   The average absorption from CaCO3 (carbonate) was approximately 27% (13 to 40%), whereas that from calcium citrate malate was approximately 36% (27 to 53%). The average difference in absorption was approximately 10% between these two sources of calcium.
   Reference: Calcium citrate malate as source for calcium. EFSA – Bioavailability of calcium from the source
   https://efsa.onlinelibrary.wiley.com/doi/pdf/10.2903/j.efsa.2007.612 ((pdf p 9-10)
2. Magnesium keeps calcium dissolved in the blood (100 x less aggregated with Mg or K than with Ca).
   Magnesium prevents vascular calcification
   doi: 10.1038/s41598-018-20241-3 2018. NIH
   Magnesium reduced calcium and phosphate fractions of 68% and 41% extracellular crystals, respectively, without affecting the fraction of magnesium. This study demonstrates that magnesium inhibits hydroxyapatite formation in the extracellular space, thereby preventing calcification of vascular smooth muscle cells.
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5794996/#:~:text=Magnesium reduced calcium and phosphate,of vascular smooth muscle cells.
   NB: The normal pH of urine is 5.8. An acidic pH, around 5, promotes the formation of uric acid, cystine and calcium oxalate stones. Source: urofrance.org
3. “Magnesium is Key to Calcium Uptake” – The British Medical Journal. 2011
   https://www.nutraceuticalsworld.com/contents/view_breaking-news/2011-09-14/magnesium-is-key-to-calcium-uptake/
   Magnesium has a direct effect on the balance of other electrolytes, including sodium, calcium and potassium.
4. Calcium to magnesium ratios <1.7 and >2.8 can be detrimental, and optimal ratios may be ∼2.0.
   BMS = bone mineral density.
   Without the proper balance of magnesium to calcium, about a 2:1 ratio – according to the study I read – calcium ends up depositing in kidneys and can create kidney stones, in coronary arteries where it can lead to clogged arteries, and in joint cartilage, rather than in bones where we need it most. The more calcium taken without the balancing effect of magnesium, the more symptoms of magnesium deficiency and calcium excess you are liable to experience," Dr. Dean says.

• Higher risk can already be found when calciuria exceeds 150–200 mg/24 h [38,39].
  => Comment: Logical. So, don’t take high level of Ca in one take.
  https://www.nutraceuticalsworld.com/contents/view_breaking-news/2011-09-14/magnesium-is-key-to-calcium-uptake/

5. Low serum phosphate concentration was also proposed as a hypothetical cause of calcium nephrolithiasis [63].
   => Optimal ratio for P / Ca according to RP is 1 / 2.2 (like in milk); never go occasionally above twice more phosphate (when eating hard cheese + meat e.g., we need to compensate excess phosphorus). (6)
   Target Ca Short answer
   I target 850 mg Ca, as RP said. Optimal between 800 – 1200 mg. Never under 650 mg.
   For me, keeping Ca/P ratio under 2 should be closely targeted. Nice objective to reach to keep PTH under control.
   I can give a link if desired if you want more details about ratios and absorption.
6. Epidemiological data from observational studies are conflictive.
   => As long you don’t take the right criteria, it won’t match.
   According to my reading & perception:
   Supplementing 500 mg Ca citrate (not carbonate) in 2 takes (2 x 21% = 105 Ca element x 2) is optimal, provided you don’t lack magnesium. If needed, Mg bisglycinate or taurate, with a meal or a snack. (6) The percentage of absorption is dose-dependent. So, small doses, 2x or 3x/d would be optimal, whenever you’re under 850 mg Ca, to reach this level. Adapt the posology.
7. Interaction between liposoluble vitamins A D3 K2
   https://mirzoune-ciboulette.forumactif.org/t127-interaction-entre-les-vitamines-liposolubles#889
   *) Useful link: Optimiser l'assimilation du calcium en supplément
   https://mirzoune-ciboulette.forumactif.org/t1935-optimiser-l-assimilation-du-calcium-en-supplement#27328

Hi,
Yes, indeed. I do take some kinds of polyphenols, but in cure when supplementing.
Why, besides beneficial effects (eye, allergies, microbiome, etc.) you have to take into account the possible effects on the pathway CyP450, a detox pathway through the kidneys. It dampens / slows down the way-out of toxins and accumulation could take place.

Polyphenols inhibit CyP450 detox enzyme
Resveratrol & Quercetin
All studies seem to agree that resveratrol, curcumin, quercetin and bioperine (from pepper) are potent inhibitors of CyP450.
CyP450 is well-known to be involved in drug metabolism (detox enzyme through liver), but also in …
So resveratrol and quercetin inhibit detox, if taken in a repetitive way. OK in cure.
http://www.longecity.org/forum/topic/40417-resveratrol-curcumin-quercetin-bioperine/

Table Drugs & CyP450 interference
http://www.anaesthetist.com/physiol/basics/metabol/cyp/Findex.htm

Link for Google search : potent inhibitors for P450
Resveratrol
http://www.google.com/search?hl=en&q=resveratrol+P450+potent+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 resveratrol P450 potent inhibit
http://www.google.com/search?hl=en&q=Resveratrol+P450+potent+inhibitor&btnG=Search&aq=f&aqi=&aql=&oq=&gs_rfai=
 Resveratrol P450 potent inhibitor

Curcumin
http://www.google.com/search?hl=en&q=Curcumin+P450+potent+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 Curcumin P450 potent inhibit
http://www.google.com/search?hl=en&q=Curcumin+P450+potent+inhibitor&aq=f&aqi=&aql=&oq=&gs_rfai=
 Curcumin P450 potent inhibitor

Quercetin
http://www.google.com/search?hl=en&q=quercetin+P450+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 Quercetin P450 potent inhibit

http://www.google.com/search?hl=en&q=Quercetin+P450+potent+inhibitor&btnG=Search&aq=f&aqi=&aql=&oq=&gs_rfai=
 Quercetin P450 potent inhibitor

Piperine (=> Bioperine)
http://www.google.com/search?hl=en&q=piperine+P450+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 Piperine P450 inhibit
http://www.google.com/search?hl=en&q=bioperine+P450+potent+inhibit&aq=f&aqi=&aql=&oq=&gs_rfai=
 Piperine P450 inhibitor

In your choices, mind fruits when taking high dose with acid (citrus fruits) (energy impact), seeds (grapes, strawberries, raspberries), histamine (citrus, pineapple, banana => H2), fructose (pear, fruit juice).
Not that you can't eat them but it must be compensated elsewhere or taken at some appropriate moment.
Try to find a balance between fructose and glucose. Target 50 g for each.
Need bicarbonate to balance citrus fruit; otherwise you're going to impact the bone skeleton. Rather potassium bicarbonate if you eat cheese and and manufactured food (high in sodium). No more than 1.2 g KHCO3, if on a regular base.
I'd balance with 200-250 mg Ca element when required (if no cheese or HD milk). Rather Ca citrate to avoid lithiasis. 0.6 g Ca citrate in a shake or water.
Note that high level citrate has an impact on platelet aggregation (blood fluidity) when taken on a regular base.

@Milk-Destroyer said in Phytoestrogen:

Do you use raw leaves?

Yes but I vary. I give examples for 2 kinds of use:

• Smoothie: often with 50 g of lamb lettuce (mâche in French). Interesting for the velvety taste + the brassicae family (detox). From time to time, I vary with small raw spinach leaves. 2 big handfuls of leaves
• mashed potato with frozen spinach or small broccoli flowers. Once a week for each (2x portions). I add one onion, lightly fried in coco oil + 1 or 2 tsp butter and 1 egg.

@pondfountain said in Phytoestrogen:

I remember seeing kale and spinach being ingredients but not sure if they are cooked properly.

Kale is only a problem when you eat very much vegetables of the same family. If you get Se and I, your thyroid won't have any problem with the brassicaceae family.
For spinach, oxalate is very high (660 mg per 100 g) we need 330 mg Ca element to neutralize it.
But potassium citrate could be useful to make it easier to get rid of.
I take both.
Mind Spinach in case of leaky gut.

@Ancap said in Summer: Blood sugar normalization:

Taking T4, T3, calcium, mag, potassium, vit d

If you take HD Vit D (> 2000 UI), you need K2.
I won't take HD Ca (> 200-250 mg Ca element). Split if you need / want more. RP said 850 mg Ca is optimal but the level depends on the contribution of basic minerals (Na K Ca Mg) compared to acidifying minerals (P S Cl).

@Ancap said in Summer: Blood sugar normalization:

Potassium levels should be okay because I drink a lot of orange juice, and take potassium citrate.

Ok because of a supplement with potassium citrates. Must be balanced for orange juice, often acidic (although interesting). It would be better to mix orange juice and potassium bicarbonate. I'd take both if your energy level is good. You could also use another kind of juice (apple, grape or pineapple), just to vary, if you get magnesium from another source (magnesium bisglycinate).
Note: 1.2 g KHCO3 is fine. It brings 0.5 g K. I won't take a higher dose of bicarboante since it can impact mTOR pathway (TH1 >< TH2 must be balanced, from one side to the other one).
Citrate for chelating oxalates, bicarbonate for adding a layer in bases. Too much citrates has an impact on platelet aggregation (blood fluidity).
When you take a too high level of T3, the body manage to turn it into rt3 (HL T3 => T4 => rT3 to get rid of excess)
High T3 to reverse T3 ratio has been linked to higher insulin resistance, something a TSH test can not capture / indicate.
If your labs show a high reverse T3 level this means that you are converting most of your T4 into reverse T3.

@Ancap
How is rT3 and potassium levels ?
It could impact glycémia.

@MuleMan said in Instant potato flakes:

you mean that these instant potatoes contain asparagin and oxalates?

Very high probability for acrylamide,
moderate for oxalates in potatoes peeled. Chips and flakes are heated to get the desired form and become crispy.

You lack potassium and a useful substrate for the intestinal flora

1. Potassium:
   The ratio between sodium and potassium will determine fluid and electrolyte dynamics, blood pressure activity, nervous system output and energy production and utilization.
2. Fiber
   25-30 g fiber is required to optimize microbiome. But not now.
   Sulfur odor is the sign the second part of your colon is invaded by phila which have nothing to do there.
3. Consequence:
   Your adrenal glands react to this situation.
   Connection between the brain and the stomach through the vagus nerve.
   PS: I'm not going to develop, and how to deal with. Guess why!?
   NB: Of course, if you suffer from gut irritation, you’re not starting with adding insoluble fibers.

We need first to calm down the overexpression / the overgrowth of some bacteria where they shouldn’t be.

In summary: Weaken – kick and push out.
Coordinated and planned tactic, which results in a structured scheme:
 Weaken (deprivation of resources but not complete abstinence)
 Organize to knock out (limiting the ability to adapt)
 Machin-gun (with increased die-off) + assistance to evacuate LPS endotoxins
 Consolidation (nutrients useful to ensure diversification of commensal bacteria + enhancing peaceful communication through the vagal nerve between the brain and the stomach).
Occupy the place (diversified menus and possible contributions of specific strains depending on the terrain, e.g. if you suffer from allergies / histamine intolerance or not.

Asparagin gives acrylamide when ...
Be careful if you use almond flour/powder, and eat chips, and to a lesser extent almond cake, because almonds and potatoes are foods rich in asparagine. Heated above 120 and especially 130° C, asparagine transforms itself into acrylamide, toxic: It is a carcinogenic glycotoxin (120–130° C = 248–266° F).
Acrylamide is formed when asparagine, a natural amino acid, reacts with sugars, such as fructose or glucose. This reaction, however, only occurs if the cooking temperature reaches a certain degree, which varies depending on the properties of the product and the cooking method. This will not be the case if the potato is cooked in water or steamed (not by pressure), but if it is fried or roasted.
Remember that only the dose and frequency make a product become poison!
NB: When you put lemon juice or cider vinegar in a cake or bread, less acrylamide is formed.

@Njegos said in Very bad circulation:

I can hear my stomach often, sounds

Ok, it seems +/ OK. If your stomach makes noise from time to time, it's not a problem, except you have then difficulties to assimilate what you've eaten.
Take it into account and adapt yourself to the situation. Otherwise you'll irritate your linen tissue and won't assimilate all the nutrients.
Need more info to advise what to do if you want to correct the problem. Note when, after which kind of food, how much, how long it lasts, at midday or at the evening.

@MuleMan
Mind asparagin.
Heat above 120 / 130 dégrée C.
No stagnation ,(transit).
Bring enough citrates or calcium (oxalates).

You have difficulty concentrating, anxiety, cold extremities, cramps, random transit or insufficiency, etc. Not limiting, but there are at least 2 symptoms characteristic of an endocrine and metabolic disorder.
Équilibre électrolytique et fonction surrénalienne (adrenal functions)
https://mirzoune-ciboulette.forumactif.org/t2078-equilibre-electrolytique-et-fonction-surrenalienne-adrenal-functions#29962
Note: In French (translator needed) but with sources and references in English