@LetTheRedeemed said in I need x-rays:
do you hold a smart phone for extended periods of time?
Well seen: it could explain many things.
Pain and arthritis suspected
If general localization (hands, neck, ankles) arthritis inflammation is due to two possible factors, bacteria or a molecule (wga from wheat).
Here it’s not the case. If testimony is asked, see Jacqueline Lagacée who‘s suffered from very painful arthritis in her hands (immune cause).
DavidsPS has made a good suggestion to optimize carburation (appropriate fuel) but I’m going to put in excerpt some citations from ray PEAT, and you’ll make your mind to see you are going to take it into account or left it aside. Note it’s only a part of the problem.
Therapeutic effects of niacinamide
From Ray PEAT
“It’s the stored PUFA, released by stress or hunger, that slow metabolism. Niacinamide helps to lower free fatty acids, and good nutrition will allow the liver to slowly detoxify the PUFA, if it isn’t being flooded with large amounts of them. A small amount of coconut oil with each meal will increase the ability to oxidize fat, by momentarily stopping the anti-thyroid effect of the PUFA. Aspirin is another thing that reduces the stress-related increase of free fatty acids, stimulating metabolism. Taking a thyroid supplement is reasonable until the ratio of saturated fats to PUFA is about 2 to 1.”
“In the same way that topical lactate can cause vasodilatation and disturbed energy metabolism (Rnedle, et al., 2001), topical niacinamide, progesterone, vitamin K, and coenzyme Q10 can improve the metabolism and function of the local tissues.”
“The same better-late-than-never philosophy can be applied to Alzheimer’s disease, Parkinson’s disease, and other degenerative nerve diseases. Aspirin protects against several kinds of toxicity, including excitotoxicity (glutamate), dopamine toxicity, and oxidative free radical toxicity. Since its effects on the mitochondria are similar to those of thyroid (T3), using both of them might improve brain energy production more than just thyroid. (By activating T3, aspirin can sometimes increase the temperature and pulse rate.)
Magnesium, niacinamide, and other nerve protective substances work together.”
“Glucose and niacinamide work very closely with each other, and with thyroid hormone, in the maintenance and repair of cells and tissues. When one of these energy-producing factors is lacking, the changes in cell functions – a sort of pre-inflammatory state – activate corrective processes.”
“Although this is an ecological problem, it is possible to decrease the damage by avoiding the polyunsaturated fats and the many toxins that synergize with them, while increasing glucose, niacinamide, carbon dioxide, and other factors that support high energy metabolism, including adequate exposure to long wavelength light and avoidance of harmful radiation. As long as the protective factors are present, increased amounts of protective factors such as progesterone, thyroid, sugar, niacinamide, and carbon dioxide can be used therapeutically and preventatively.”
“The features of the stress metabolism include increases of stress hormones, lactate, ammonia, free fatty acids, and fat synthesis, and a decrease in carbon dioxide. Factors that lower the stress hormones, increase carbon dioxide, and help to lower the circulating free fatty acids, lactate, and ammonia, include vitamin B1 (to increase CO2 and reduce lactate), niacinamide (to reduce free fatty acids), sugar (to reduce cortisol, adrenaline, and free fatty acids), salt (to lower adrenaline), thyroid hormone (to increase CO2). Vitamins D, K, B6 and biotin are also closely involved with carbon dioxide metabolism. Biotin deficiency can cause aerobic glycolysis with increased fat synthesis (Marshall, et al., 1976).”
“In some of the publications claiming that resveratrol increases lifespan, it was reported that niacinamide had the opposite effect, suppressing Sir2, the longevity gene, and shortening the organism’s lifespan. To put their claims into context, it’s helpful to look at a variety of experiments involving treatment with niacinamide.
It protects nerves, vascular cells, insulin-producing cells in the pancreas, and a variety of other types of cell from cell death produced by lack of oxygen, excitotoxicity, endotoxin, and a variety of stressors and toxins. (Niacinamide acts in many ways as a negation of resveratrol; for example, resveratrol interferes with the ability of the beta cells to secrete insulin [Szkudelski, 2007]).
Niacinamide protects mitochondrial respiration from many of the age-related factors that can damage mitochondria and decrease energy production. Lipopolysaccharide, the bacterial endotoxin, increases the production of the free radical nitric oxide, leading to the secretion of inflammatory mediators and the suppression of energy production by the mitochondria. These effects are blocked by niacinamide (Fukuzawa, et al., 1997). Calorie restriction also protects mitochondrial respiration, in yeasts (Lin, et al., 2002) and rats (Broderick, et al., 2002)
The “replicative lifespan” of human cells in vitro is extended by treatment with niacinamide (Kang, et al., 2006).
In an experiment with human keratinocytes in vitro, resveratrol had the opposite effect, reducing their ability to divide (Blander, et al., 2009). By the definitions of “aging” used by the advocates of the rate-of-living theory, this experiment suggests that resveratrol causes premature aging. Estrogen has a similar effect on keratinocytes. Resveratrol, nitric oxide, and estrogen, unlike niacinamide, suppress mitochondrial respiration. Resveratrol inhibits the formation of progesterone (Chen, et al., 2007), which is synthesized in mitochondria.”
“The amino acid theanine, found in tea, has been reported to decrease the amount of serotonin in the brain, probably by decreasing its synthesis and increasing its degradation. This seems to be the opposite of the processes in hibernation. Progesterone, thyroid, and niacinamide (not nicotinic acid or inositol hexanicotinate) are other safe substances that help to reduce serotonin formation, and/or accelerate its elimination. (Niacinamide seems to increase serotonin uptake.)”
“Niacinamide, by reducing lipolysis, would be another anti-inflammatory agent that could help to interrupt the degenerative processes initiated by exposure to radiation.”
“The “treatment” for intracellular fatigue consists of normalizing thyroid and steroid metabolism, and eating a diet including fruit juice, milk, some eggs, liver, and gelatin, assuring adequate calcium, potassium, sodium, and magnesium, and using supplements of niacinamide (B3), aspirin, and carbon dioxide when necessary.”
“Niacinamide, progesterone, sugar, carbon dioxide, and red light protect against both free fatty acids and prostaglandins.”
“The foods that nourish the patient well enough to support healing while permitting energy reserves to be built up are also the foods that don’t interfere with the hormones, that don’t cause spurious excitation of the tissues. The polyunsaturated fats directly stimulate the stress hormones, activate the excitatory amino acid signals, and directly excite cells, while the saturated fats have opposite effects, and are anti-inflammatory, and also don’t interfere with mitochondrial function. When we eat more carbohydrate than can be oxidized, some of it will be turned into saturated fats and omega-9 fats, and these will support mitochondrial energy production. Carbohydrates in the diet also help to decrease the mobilization of fatty acids from storage; niacinamide and aspirin support that effect.”
“Niacinamide, by lowering free fatty acids and regulating the redox system, supporting sugar oxidation, is useful in the whole spectrum of metabolic degenerative diseases.”
“The inflammatory factors that can promote cell growth can, with just slight variation, deplete cellular energy to the extent that the cells die from the energetic cost of the repair process, or mutate from defective repairs. Niacinamide can have an “anti-inflammatory” function, preventing death from multiple organ failure, by interrupting the reactions to nitric oxide and peroxynitrile (Cuzzocrea, et al., 1999). The cells’ type, environment, and history determine the different outcomes.”
“The same simple metabolic therapies, such as thyroid, progesterone, magnesium, and carbon dioxide, are appropriate for a great range of seemingly different diseases. Other biochemicals, such as adenosine and niacinamide, have more specific protective effects, farther downstream in the “cascade” effects of stress.”
“Thyroid hormone, vitamins A and E, niacinamide (to inhibit systemic lipolysis), magnesium, calcium, progesterone, sugar, saturated fats, and gelatin all contribute in basic ways to prevention of the inflammatory states that eventually lead to the amyloid diseases. The scarcity of degenerative brain disease in high altitude populations is consistent with a protective role for carbon dioxide.”
“Eliminating polyunsaturated fats from the diet is essential if the bystander effect is eventually to be restrained. Aspirin and salicylic acid can block many of the carcinogenic effects of the PUFA. Saturated fats have a variety of anti-inflammatory and anticancer actions. Some of those effects are direct, others are the result of blocking the toxic effects of the PUFA. Keeping the stored unsaturated fats from circulating in the blood is helpful, since it takes years to eliminate them from the tissues after the diet has changed. Niacinamide inhibits lipolysis. Avoiding overproduction of lipolytic adrenaline requires adequate thyroid hormone, and the adjustment of the diet to minimize fluctuations of blood sugar.”
“Niacinamide inhibits the release of free fatty acids from the tissues, and thyroid sustains the oxidation of glucose.”
“Niacinamide, like progesterone, inhibits the production of nitric oxide, and also like progesterone, it improves recovery from brain injury (Hoane, et al., 2008).”
“Since the blood becomes more concentrated, viscous, and clottable during the night (especially during long winter nights), the risk of a heart attack or stroke would probably be reduced by drinking orange juice before getting out of bed (and at bed-time), to dilute the blood and decrease adrenaline and the free fatty acids, which contribute to the increased tendency to form clots in the morning. (Assanelli, et al., discuss the importance of adrenaline in morning/winter sudden death; Antoniades and Westmoreland show that the availability of glucose can override major promoters of clotting and bleeding.)
Things to reduce the stress-related coagulopathies: Sugar and niacin to minimize the liberation of fatty acids, progesterone and thyroid to protect against estrogen and to avoid hypoglycemia (which increases adrenaline and free fatty acids and accelerates clotting), magnesium and gelatin (or glycine), to protect against intracellular calcium overload and hypoxia, and vitamin E and salicylic acid for anti-inflammatory effects, are major nutrients that protect the circulatory system against clotting, bleeding, edema, and tumefaction.”
Dr. Ray Peat Ph.D.
https://www.functionalps.com/blog/2012/03/20/ray-peat-phd-on-therapeutic-effect-of-niacinamide/
Therapeutic effects of niacinamide
Carbon dioxide (CO2), niacinamide (B3) and aspirin are protective towards mitochondrial respiration.
“Niacinamide, used in moderate doses, can safely help to restrain the excessive production of free fatty acids, and also helps to limit the wasteful conversion of glucose into fat. There is evidence that diabetics are chronically deficient in niacin. Excess fatty acids in the blood probably divert tryptophan from niacin synthesis into serotonin synthesis.”
Ray Peat
Editor’s Note: Ray PEAT advices 50 – 70 mg niacinamide, beginning with a low amount.
In another question form readers, RP advices to take 10 mg B3 from time to time to enhance mitochondrial breathing, when things have returned to a more “normal” state.
Comment LucH: I’ll make an association of several points; just niacinamide is not going to solve painful tensions.
Mind niacin (skin flush) if above 20-25 mg. Take niacinamide.
Mind the kind of B6. B6 PLP is fine but some people won’t tolerate more than 20-25 mg (brain sensitive). When taking high dose B6 (100 mg), we should begin with moderate amount. Make staples and pause. I’ve done it so; 5 days per week, for 3 weeks. Pause one week, Again 3 weeks. Stop. 3 or 4 times a year if needed. Excess B6 is going to bring problem with GABA (self-protection due to residual molecules).
