@amizon said in High-dose thiamine troubleshooting:
Any suggestions would be much appreciated, thanks.
Hi, every body (1st post).
Too much thiamine could occasion issues related to histamine and acetylcholine excess that doesn’t make sense immediately. High level thiamine is a burden for the detox system CYP450.
Moreover we need some B2 after a while when taking B1 supplement. Mostlylurking has explained it very well. Thanks, by the way. 
B2 is not required every day.
And by the way, I read a post from redsun on RP forum (where I no longer go to), saying B6 could counteract symptoms brought by disorder from GABA and serotonin.
Mind the kind of B6. No pyridoxine (PNP). PLP must be taken with pause. I can explain how I did, if you want.
LucH