Posts made by LucH

Hi,
I’d try selenium in a nebulizer (not a spray) to reach lung cells.
Se => glutathione.
E.g. Nutricology selenium liquid, 8 oz (236 ml).
½ tsp = 100 mcg Se sélénite
On iherb.com or vitacost.com
Morning and evening (in nebulization, otherwise useless), for 15 days. Pause 10 days. Once more.
Référence: Dr Klinghardt, when trying to cure asthma (inflammation).
Note: I suppose you’ve informed there are histamine liberator and histamine producer (PDF). I you eat food with biogenic amines like banana, you’ll overload the liver.
Mind excess stress too. + Sulfite, glutamate.
To help getting rid of histamine, I’ve been using naturDAO 1 000 000 UI (DAO = enzyme to metabolize excess histamine).

@AndrewPeatMatrix
Make a plan: step by step..
A carrot salad once a day IS fine (or twice if between meals).

@AndrewPeatMatrix
Yes, it's a possibility.
But you'll have to be patient, with staples +/ 10 days (10-15 days) to let the brain adjust the whole thing. With high and down waves in mood / energy.
But before doing that, I'll deal with LPS toxins, relieve liver and bring useful nutrients through a balanced diet. Then, your thyroid will be in better sheets to recover, to avoid "adrenal exhaustion" (overburning).
Note:

1. liver is the central organ to pamper / help.
2. If you only take T3 or T4, believing / seeing how it's going to happen, it's like shooting into your feet.
   T-3-4 are not going to solve the dysbiosis and help to get rid of LPS toxins.

You need to balance the communication between the HPA axis.

After a search on the fuctioning, here is what I've obtained.
Anticholinergic effect of Cyproheptadine
It’s an Acetylcholine blocking agent. Possibility of cumulative effect with other anti-cholinergic molecules.
Acetylcholine is essential to the functioning of the body. It helps you stay vigilant, keep a regular heart rate, breathe, digest food, sweat and empty the bladder. When you take an anticholinergic drug, it acts on many parts of the body at the same time. In older people, the liver and kidneys no longer eliminate drugs on very optimal way (accumulation). They therefore become more sensitive to side effects (dry mouth, urinary problems, constipation, somnolence and confusion)
=>It ’s a question of ground and quantity too. Thus, if you can manage, why not!
Note; I won't use a brake before getting rid of excess when exciting serotonin.
Caffeine should be excreted before taking another dose.
Personally, it's 4 or 5 hours between two cups 125 ml (half-life).

@Ilias-Ant said in HPA Anxiety Liver Blood Sugar:

what is RPF i m not familiar with it...

RP = abbreviation for Ray Peat => old RP forum (RPF).
Don't go there any longer (dictatorial behavior, seems to become insane 'cause the head-administrator must have burned a few fuses...

@Ilias-Ant said in HPA Anxiety Liver Blood Sugar:

So you think Cypro is a no for me?? even in the smallest dosage?

Well, I haven't any advice on cypro. I've never used it, nor gone deep into the functioning of the molecule. I know is an anti-histamine H1. So it could do the job (calm down).
I know several people on RPF have used it with success.
I need to have more info on possible side-effects before giving a personal advice.

Hi, welcome.
I use 3 elements to manage excess stress

• glycine. Mine comes from collagen (hydrolyzed peptides). 2x 2 tsp collagen powder with a shake.
• magnesium bisglycinate would be fine (1 scope 2.5 g). To be used after stress event. No use before an event. 450 to 900 mg per day.
• L-theanine 250 mg. Gaba-like effects.
  Of course if you don't adapt what amplifies the stress, it won't do much.
  => Need for a relax therapy: deep breath (sophrology) or EFT. Both are fine. The last one to get rid of reluctant bad things.

1. I would treat the situation as if you were digestive enzyme deficient to relieve the metabolism of macronutrients. See details below (1)
2. Consider you’re hypothyroid, even if you’re border line with the TSH (between 2.5-5), whenever other symptoms are present. Here, it’s the case: brain fog, fatigue, digestion.
   What about your body temperature? (2)
3. You’ll need to be assisted: a comprehensive therapist who‘d accept to follow your advice when asking to follow one target.
4. Get informed before beginning a treatment. You’ll probably need recovering staples in order to get enough energy. Handle as if you got SIBO / SIFO.
   See my log on my forum: Journal de suivi – Luc. Démangeaison et histamine (histamine intolérance, dysbiose)

• Témoignages SIBO / SIFO
  https://mirzoune-ciboulette.forumactif.org/t2029-demangeaison-et-histamine-journal-de-suivi-2#29583

5. If you kill bacteria (bacterial overgrowth = dysbiosis), you need to assist the liver and to understand how to manage whenever you feel uneasy / ill / upset / worried / … (3)
6. See how other people manage to do without an appropriate therapist.
   Thyroid Log, by GreekDemiGod.
   https://bioenergetic.forum/topic/1659/thyroid-log?_=1720081167607
   PS: You won’t take T3 supplement but will observe how to manage / open an appropriate log with useful info. Make a difference between the facts and what you feel. Not based on short term.
7. If you feel as in a brain-foggy state, you’ll need to be assisted by a therapist to be supervised. I can’t do that.

References

1. Enzyme deficience

• Enzymedica lypogold + betaine HCl (Now Food) once at supper in case of difficulty to digest meat.
• Need to get informed on the way to optimize digestion (fibbers at first), to avoid hypoglycemia (Jessie Inchauspé). If you don’t get insulin spikes, there won’t be any food storage in the adipocytes (fat) unless you stress a lot. No weight lose if you often stress. A relaxation technique is then required: yoga, eft, sophrology or a simple breathing technique.
  Collagen powder (glycine => gaba-like = relax + half of the protein intake, possibly) and L-theanine supplement 250 mg (relaxes brain); it would be a good choice.

2. An endocrinologist is needed. Here, it’s a doctor in internal medicine. But when you’re borderline (TSH < 5), they don’t take it into account. Moreover there is a huge delay (1 year for well-known doctors, 3 months in university hospital).
   Note: Most medicine practicians are going to treat the dysbiosis with antibiotics. OK, but it won’t be sufficient. You must have a plan when you aim for a goal (anticipation).
3. SIBO and BIOFILM
   When SIBO has been installed for some time (+/ 1 year), bacteria have had time to settle. They communicate with each other (Quorung Sensing) and protect themselves from attacks behind a biofilm. You won’t kill all the bacteria. But you need to occupy the place with new ones. Life hates a vacuum. You have to occupy the place to avoid a timely selection of multi-resistant bacteria.
4. You’ll need some thiamine (B1) and PLP (B6) high dose, with a strict protocol (see Dr. Allil Overton) to help the communication between the brain and the stomach, through the HPA axis. The microbiota-gut-brain axis is a bidirectional signaling pathway that operates through neural, endocrine, immune, and metabolic pathways.
   HPA axis: The hypothalamic-pituitary-adrenal (HPA) axis is a crucial communication system that manages the body’s response to stress. It involves three key organs: the hypothalamus, pituitary gland, and adrenal glands.
   Note: B2 will be needed too. Not only. I’d take a vitamin B complex 50 mg twice a week (co-enzyme). See my forum for a selection if you can’t find one without rubbish excipients. => Mirzoune et Ciboulette + Vitamines B Complexes & Dioxyde de titane.
   https://mirzoune-ciboulette.forumactif.org/t845-vitamines-b-complexes-dioxyde-de-titane#14314
   Note: I take Pure Encapsulation B Complex Plus, 2x/wk.
5. Your liver is overburdened like many people …
   When you’ll lose weight, your fatty liver will recover a lot but not enough. Never try to lose more than 2 Kg (4 pounds) a week (with staples: standstill levels will arise). Never go under 80 % of your required calories, otherwise you’ll get problems.
   => A salad carrot once a day to drive LPS toxin away.
   => I would try to get accustomed with green shakes (40% fruits, and 60% veggies). See Valya Boutenko’s video to avoid common errors. Not too much fructose. Drink only once a day, with useful micronutrients (Mg bisglycinate/ K citrate, taurine and phosphocalcium if you can’t get enough Ca (850 mg Ca/ day) from your menus. I follow my daily contributions through a log: cronometer.com. Easier to understand what’s wrong.
   In this shake, I’d add collagen powder (1 Tsp : +/ 5 gr). Begin progressively. Target 10-20 gr/day powder.
   See “How to make a green smoothie” - Valya Boutenko.
   https://youtu.be/552mPSVfFWo
   https://youtu.be/552mPSVfFWo (same source, update)
   Copy the link in a search engine (no click).
   To make a good smoothie you should know the difference between the existing fibers. There are two kinds of fibers: soluble fibers and insoluble fibers. See suggestion on my forum.
   https://mirzoune-ciboulette.forumactif.org/t395-reussir-un-delicieux-smoothie?highlight=smoothie

AndrewPeatMatrix asked:
Could supplementing T3 help?
=> You’ve already an appropriate level of T3. But how does it end up?

• When T3 has been bound to TBG for the transport to the target, bound-T3 must be freed.
  General info
  T3 has 2 forms: bound and free. Bound T3 is attached to a protein and free T3 is not attached to anything. The free T-3 test measures only the amount of free T3. The total T3 test measures both free and bound T3 in your blood.
  Most circulating T3 is produced outside the thyroid in peripheral tissues by monodeiodination of T4. Only one fifth of circulating T3 is secreted directly by the thyroid.
  https://www.msdmanuals.com/professional/endocrine-and-metabolic-disorders/thyroid-disorders/overview-of-thyroid-function#Synthesis-and-Release-of-Thyroid-Hormones_v981233

Type of tests for Triiodothyronine (T3)
https://www.verywellhealth.com/interpret-your-thyroid-test-results-3231840
Triiodothyronine (T3) is the active thyroid hormone converted from T4. As with T4, there is both bound and free T3.
T3 blood tests include:
• Total T3: The total amount of T3 (bound and unbound) in your bloodstream
• Free T3: The amount of unbound T3 available for use in tissues
• Reverse T3: An inactive form of T3 that has no utility but can block free T3 from entering tissues
What causes high TSH and high T3?
Search with: "High TSH and high T3" (with brackets)
=> TRH in addition to increasing TSH causes to rise prolactin level. A test for prolactin and estrogen could give a clue.
TRH = Thyroid releasing hormone.

More info is needed.

Do you have any symptoms of hypo-metabolism (because of High TSH)?
Any inflammation of stomach or liver? Etc.
Thyrotoxic Crisis (Thyroid Storm) ?
I didn’t find a suitable path with the information I had.
We have to proceed by elimination. I Haven't a clear image.

Useful links
*) ## Vitamin D levels reduces cortisol by 40 % (> 45 ng/ml).
https://raypeatforum.com/community/threads/vitamin-d-reduces-cortisol-in-humans-by-40.8977/#post-270013
Haydut said:
No need to introduce the well-known vitamin and its role in pathologies like diabetes and even cancer. The interesting part is that the study was very short (only 14 days) and used not too high of a vitamin D does (2,000 IU daily). A key finding was the reduction in cortisol by over 40%, as well as the reduction in blood pressure. The reduction in blood pressure has also been confirmed in another human study, (see here: viewtopic.php?f=218&t=5087) and given cortisol's role in the pathology the effect of vitamin D is not surprising.
http://www.endocrine-abstracts.org/ea/0038/ea0038p204.htm

*) Which nutrients to optimize the function

• Tyrosine intervenes as a precursor of thyroid hormones. This amino acid is indeed attached to iodine atoms to form thyroid hormones.
• Manganese is essential for the synthesis of thyroxine (T4). (Mind excess Mn!)
• The enzyme that allows the conversion of T4 (pro-hormone) to T3 (active hormone) requires the presence of mineral cofactors:

Copper, iron, selenium and zinc + Mg

• Group B vitamins also contribute to the proper functioning of the thyroid gland. They act in synergy. I’d take a co-enzyme formula, twice a week.
• Other nutrients could also help to improve thyroid function, vitamins A (retinol), C and E, without forgetting magnesium, which prevents the reduction in the thyroid activity.
  *) Mind excess estrogen and regular stress.
  Estrogen Dominance & Thyroid Function

Estrogen dominance (ED) mimics hypothyroidism by interfering with thyroid hormones.

One way that estrogen dominance impacts on thyroid health is by stopping the conversion of T4 into T3 thyroid hormone which leads to low T3 levels. But you’re not concerned.

ED inhibits Thyroid action and lowers the rate of metabolism of the Body.

Estrogen increases Thyroid Binding Globulin (TBG) in blood hindering TH activity. Thyroid

hormones are carried by Thyroid Binding Globulin, a specific protein produced by the liver. An increased number of binding proteins hold onto more of the thyroid hormone. Since protein-bound hormones (“tied-up”) can't bind to their receptor, this reduces the free thyroid hormones in the blood that will be available to cells for maintaining metabolism, even though blood TH levels may test normal or high.
NB: Circulating thyroid hormone is highly bound (>99%) to thyroid binding globulin.
In cases of high TBG, more thyroid hormone will be bound, decreasing free hormone in the blood.

Expressed in another way:
Estrogen increases levels of thyroxine-binding globulin (TBG). This protein binds and transports thyroid hormones. Bound thyroid hormones are inactive; so elevated TBG can contribute to a hypothyroid state. A thyroid panel with added TBG can assess for hypothyroidism due to estrogen dominance.

How to balance
If excess estrogens inhibits thyroid, natural progesterone counterbalances this effect. Treating estrogen dominance and restoring hormone balance automatically reverses hypo-like symptoms. It takes time …
Changing your diet is one element. See carrot salad receipt. Cleansing or protecting your liver is another way to facilitate homeostasis (to get rid of excess estrogen) but you need eating enough proteins to detoxify…
Chronic stress 1:
Stress of any kind decreases progesterone levels to increase production of cortisol…
So, reduce stress & environmental toxins such as fluoride, chloride, pesticides & pollutants (mercury, arsenic in rice), lithium or beta-blockers …
Chronic Stress 2
Pregnenolone is the building block for all sex hormones and cortisol, the body's stress hormone. The pregnenolone steal is the phenomenon that occurs when high stress forces the upregulation of cortisol synthesis from pregnenolone, reducing the availability of pregnenolone to be converted to other hormones. The pregnenolone steal contributes to estrogen dominance by impairing progesterone synthesis and creating an elevated estrogen-to-progesterone ratio.
Source: rupahealth.com – a functional medicine protocol for estrogen dominance

*) Interesting links:
http://raypeat.com/articles/aging/aging-estrogen-progesterone.shtml
http://www.vrp.com/hormone-support/the-hidden-causes-behind-hormonal-imbalances
http://thyroid.answers.com/thyroid-health/what-role-does-estrogen-play-in-thyroid-function-and-health
http://raypeat.com/articles/hormones/h1.shtml

*) interaction between liposoluble vitamins
Synergy effect with vitamin E
“Vitamin C regenerates vitamin E and vitamin E protects β-carotene, helped in this by polyphenols. In the event of β-carotene supplementation, vitamin C regenerates vitamin E and β-carotene, and β-carotene seems to protect vitamin E without really explaining this phenomenon "(1)
Savings effect
Vitamin E is not just a vitamin. Vitamin C makes it possible to recycle oxidized vitamin E and thus prolong its lifespan. The same goes with glutathione which is thus saved for other more useful functions (detox). Glutathion is our antioxidant master. Vitamin E protects against the deleterious effects of polyunsaturated fatty acids when the latter are in excess. And it is quickly done!

1. John Libbey Eurotext - Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions. Auteur : Claude Louis Léger.
   *) La vitamine E est un anti-œstrogénique, plus qu'un simple antioxydant. Elle empêche les AGPI de se comporter en pro-œstrogènes inflammatoires dans l'organisme. 20-25 mg par jour (au moins 2 tocophérols)

Hi,
The answer won't be short, sorry.
AndrewPeatMatrix situation
High TSH (3.82)
High T3 level

TSH thyroid standards
A high concentration of TSH indicates that the thyroid is not sufficiently active: the pituitary gland compensates by developing an excessive amount of TSH in order to stimulate the thyroid to produce T3 and T4.
A light or more serious hypothyroidism affects women more often, in particular.
Standards
According to the American Thyroid Society (American Thyroid Society), the normal TSH must be between 0.4 and 2.5.
http://www.thyroid.org/patients/brochures/hypothyroidism _web_booklet.pdf
In Canada, normal rates are said to be 0.35 to 4.7. However, most scientists consider that the normal rate should not exceed 2 !!
In the United States the maximum standard has been 3 for a long time.
Comment: A low or a high TSH results from a communication between the brain (hypophysis) and the thyroid. So, the link must be optimal.

I see 2 main points:

• How to optimize the communication with the thyroid (useful nutrients to bring and halogens to avoid).
• Relieve liver.
• How to reduce excess estrogen and regular stress.
  Note: High rate PUFA, from 3 g (supplement omega-3), will act as a metabolism inhibitor, which can worsen a situation of hypothyroidism.
• With high T3 (and high TSH), it could be a problem with excess estrogen (estrogen dominance). T3 is ineffective because of a problem with too much thyroxine-binding globulin (TBG). See the explanation below.
  Make a search with: TBG T3 and estrogen dominance if other further info is required.
  See some interesting info on next post.
  Hope it could help.

Thanks for so much contributing. it's a pleasure to change one's mind...
My contribution

The second one has been refused by the system (not enough privilege) for an animated gif!
Except with the French Version.
angry-cat-firing. E.gif

@edouard said in Carrots with or without meals?:

@LucH Ahhh interesting! And how to reeducate MMC?

Info on MMC. See the second part for reeducation of MMC
The migrating motor complex (CMM or MMC in English) is an electrical and contractile activity of digestive motility which takes place in the inter-digestive periods (between two meals), and interrupted by food intake. Each MMC is accompanied by an increase in gastric, pancreatic and duodenal secretions. They are thought to serve to evacuate contents in the small intestine between meals, and also to transport bacteria from the small intestine into the colon. An alteration of this phase notably favors the development of chronic bacterial colonization of the small intestine, a source in particular of bloating, diarrhea, or even steatorrhea, of the majority of food intolerances. When contractile activity is low, we then speak of lazy intestines. Support and rehabilitation is often necessary, with a prokinetic.

I’ve used Resolor 0.5 mg, as prokinetic (1 tablet 1 mg cut into 2 pieces) which is classified as laxative but not used so).
*) Journal de suivi de Luc. Démangeaison et histamine
https://mirzoune-ciboulette.forumactif.org/t1985-demangeaison-histamine-journal-de-suivi
Note: I had first to solve problems with gas and flatulence. Bacterial overgrowth + histamine.
I use enterocoated softgels with essential oil (see my log for more details). + Specific probiotics afterwards.
I use NaturDAO 1 000 000 UI for histamine. (+ Quercétine anhydride for preventing mastcell activation, at the beginning). Bacterial overgrowth is under control (solved). MMC too (Resolor 0.5 mg 2 months).
Still taking 1 caps Naturdao before breakfast for histamine. Under control but must be consolidated.
Histamine degraders (Chandler Marrs):

• Bifidobacterium infantis
• Bifdobacterium longum
• Lactobacillus gasseri
• Lactobacillus rhamnosus
• Lactobacillus salivarius
• Lactobacillus plantarum
  Note: B1 (thiamine) is a histamine liberator and a DAO inhibitor ! No aspirin, curucumin, codeine, gelatin when in crisis.

@edouard said in Carrots with or without meals?:

@LucH What does MMC means?

MMC = Migrating Motor Complex.
When there is slow intestinal transit (only once for stools), starch ferments in the second part of the colon. Mind with potatoes (soluble and insoluble fibers). If repetitive, there is often overproduction of gaz because of bacterial overgrowth.
MMC becomes then weak / lazy or absent. Must be reeducated.

Hi,
Carrot salad is going to amalgam some LPS toxins and possibly other nutrients from the meal.
So, once a day is advised.
According to RP, bamboo shoots or raw carrots, helps to reduce endotoxin and serotonin.
“Some fibers, such as raw carrots, that are effective for lowering endotoxin absorption also contain natural antibiotics, so regular use of carrots should be balanced by occasional supplementation with vitamin K, or by occasionally eating liver or broccoli.”
It could be best to eat it between meals, but I don't. I eat it at the beginning. best raped but not always. Fine with apple vinegar too. I sometimes add an apple with 2 big carrots.
Best option is to add some olive oil to take LPS away (MUFA are advised) fçr optimal convey.
Note (from RP):

• The carrot salad improves the ratio of progesterone to estrogen and cortisol,
• Estrogens which has been excreted in the bile can be reabsorbed from the intestine if there is slow transit time and too little fibber.
  Personal comment: Mind MMC if not going to toilet (feces) 2x/day. Stagnation of intestinal transit makes the bed for overgrowth of bacteria (dysbiosis) and low-grade inflammation.

Hi,
@CO3
I’ve just seen your post.
Good initiative but it would be more practical if we weren’t obliged to click on the link to know the provenance. If someone could edit, it would be nice. THANKS.
For the Mg Bisglycinate from HSN, I tested: I threw it in the trash: I don't like the taste (disgusting) and it is badly diluting. It’s +/ OK with lemon juice. I prefer the one from nutrixeal.com (France) but there is surely cheaper. Quality has a price.
I buy me gelatin (collagen peptides) at nutrimucle.com

Hi,

1. If your temp is not good, you've got a problem of carburation: thyroid is often the culprit, even when TSH is OK. Limit but OK. TSH indicates only your brain didn't perceive a problem. Problem of analyzing the elements. I would act as if there were a problem. need more specific measures, like T3.
   I'd optimize Mg bisglycinate, Se and I.
   *) Useful nutrients
   Micronutrients as iodine, selenium, magnesium, iron, zinc, and vitamins B12, D3, and A.
   DOI: 10.1097/MED.0000000000000831
   Note: Before taking any iodine supplement, selenium has to be brought to, event in the case of Hashimoto suspected.
   *) Watch out for fluorine, chlorine and bromine
   Deiodination is essential to maintain TH homeostasis, and disruption can have detrimental effects. Halogen bonding (XB) to the selenium of the selenocysteine (Sec) residue in the Dio active site has been proposed to contribute to the mechanism for iodine exclusion.
   Xenobiotics could also inhibit Dio activity by competitively binding to the active sites of thyroid.
   Source:
   A Halogen Bonding Perspective on Iodothyronine Deiodinase Activity
   DOI: 10.3390/molecules25061328

A metabolic key (metabolic triad) is the adrenal-thyroid-pancreas triad, or the relationship between stress (cortisol), metabolism (thyroid hormones) and sugar (insulin).

All these three areas must be evaluated and treated simultaneously to improve the energy and vitality of the patient.
Source:
The thyroid madness II (Chapter 1): The Integrative and Functional Medicine Approach to Thyroid Diseases. By James Yang, MD, MPH and Andrew Heyman, MD, MHSA

2. Your suffer from dysbiosis, with a leaky gut.
   If your want it, I can develop.
   Hope it could help.

@GreekDemiGod said in How to restore glucose oxidation/ insulin sensitivity?:

I do know I have low bile output. Pale stools is probably because of that.

I'll take Betaine HCl at the evening meal (if with protein). Eat main meat at midday.
=> in order to optimize protein digestion.
If your stools are not uniform and contain undigested fats , I'll take Enzymedica Lypo Gold (with high fat enzymes). When the stools contain excess fat, they are light, soft, bulky, oily and have an abnormally smelly appearance
Fats between 15 - 30 %. Optimal at 20 % if problem.
Note: Coconut oil is easier to digest than other fats. Progressively, otherwise it will be laxative.

Crohn disease
The main clinical signs are abdominal pain, prolonged diarrhea, the emission of bloody mucus, a possible palpable mass in the right iliac pit, moderate fever, asthenia and weight loss. Biologically, there is an accelerated ESR, increased CRP (reactive Protein-C), light anemia, leukocytosis with polynucleosis and hypo-albuminemia.
Note: Erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are two markers in the blood that measure levels of inflammation.
For JS, Crohn's disease has a mechanism similar to that of colitis. The severity of the Crohn’s would be due to a difference in the waste to be eliminated, perhaps a stronger quantity, often a more complex structure. The activation of several varieties of leukocytes and the secretion of multiple pro-inflammatory cytokines cause the release and activation of matrix metaloproteinases which degrade tissues, which can generate fistulas, cracks, large abscesses and fibrous strenosis (Shanahan 2002).
The proportion of various cells and cytokines in the infiltrate suggests a much more inflammatory than immune response (Mac Dermott et al. 1993), which is corroborated by the absence of association between Crohn and HLA and the ineffectiveness of the Ciclosporin which reduces the immune response in vain (Sandborn 1995). Crohn’s is related to the pathology of elimination and not to autoimmunity. Crohn’s is for Seignalet a giant colitis, a multifactorial pathology (bacteria and food).
In Crohn's disease, certain foods have awakened certain symptoms (diarrhea, pain), even a simple exclusion diet would have put these symptoms under the nod: it is interesting to note that cereals, milk and some cooked products appear frequently challenging for patients. And JS cites case studies carried out on his patients.
The results
The hypotoxic diet has been implemented in 99 cases of Crohn’s, but he will only retain the 72 patients for whom the decline is more than one year. The results are 62 frank success, with complete or almost complete remission, 9 more nuanced results and one single true failure. JS comment
Nutritional change can remove ulcers, micro-abscess and inflammatory granulomas; in short, the inflammatory process characteristic of the Crohn’s. But it can do nothing against certain definitive lesions, such as cracks, fistulas, macro-abscess and fibrous stenosis.

@yeehawyinzer said in Crohn's Disease Drugs:

What are some alternatives to consider from a Bioenergetic lense?

Crohn's disease or irritable colon (IBS): how to soothe and get out of it?

Crohn’s is related to the pathology of elimination and not to autoimmunity. Crohn's disease has a mechanism similar to that of colitis, with high levels of inflammatory cytokines, but not correlated with HLA failure (genetic reaction).
Jean Seignalet (deceased in 2002, immunologist) has treated several Crohn’s: The results are 62 frank success, with complete or almost complete remission, 9 more nuanced results and one single true failure.
In this article, we’ll see that exclusion diets were effective to improve leaky gut (intestinal permeability), what kinds of food are beneficial and which substances to optimize homeostasis.
See original post (in French):
https://mirzoune-ciboulette.forumactif.org/t2023-maladie-de-crohn-ou-colon-irritable-ibs-comment-apaiser-et-sen-sortir#29501
Irritable colon syndrome is a functional gastrointestinal system disease. Thus, unlike Crohn's disease, no change in the structural level is present, it is rather the function of the digestive system that is altered.
Jean Seignalet (immunologist) talked about colitis, also called spasmodic colopathy, irritable colon (IBS) or functional colopathy. With an IBS we often meet an abdominal bloating, transit disorders: constipation, diarrhea or alternation of both. The colopath is often tired, sometimes even anxious or depressed, prey to various discomforts (…).
In this type of colopathy Nanda and Coll. (1989) found that exclusion diets were effective in 47 % of patients, and that many subjects were able to identify dangerous foods. With a decline of one year, the benefit is maintained. I quote Jean Seignalet, in L’Alimentation ou la 3ème Médecine – &28 : Pathologie d’élimination – - 5th edition book:
“Certainly foods have a major responsibility in colitis, but not by an allergy or intolerance mechanism. The disease is not due to the assault of the colic mucosa by a poorly tolerated food. Raws and fruits are only triggers of crises. They are only dangerous because the colic wall is the seat of permanent inflammation. It is therefore we must find the root cause of the inflammation in order to treat it. Only an etiological treatment can be able to cure a colitis.”

Inflammation of the colon wall (inner lining)
Some patients have often been offered a treatment oriented towards psychopathy – it happens in the head at first time – by modulating the diet with a few common sense prescriptions (eating homemade, Mediterranean style), as soon as the inflammation of the intestinal walls will allow it ...
Inflammation – not an autoimmune reaction – is due to the assault of the mucosa by one or more poorly tolerated food, not by an allergy or intolerance mechanism. The disease is not of psychic origin, either. The fatigue and signs of anxiety are only the consequence of a mined ground. The motility is altered and the sensitivity of the colon is exacerbated. Otherwise expressed, these are symptoms of the colitis we have there.
For Jean Seignalet, this is the most likely observation, confirmed by the following analyzes: this inflammation is demonstrated by the excessive presence in the colic wall of various varieties of leukocytes, in particular mastocytes, macrophages and T lymphocytes (Fioramonti et al. 2001) (Barbara et al. 2002).
Similarity with Crohn: intestines hypermeability (leaky gut)
The attack on the mucosa of the intestines through modern diet and certain dangerous bacteria it promotes, the leaky gut with passage of bacterial and food macromolecules, this causes a permanent blood infiltrate. Drugs should not be given to slow down digestive transit, but on the contrary let this flow expurgate the body of its waste.
It is therefore logical to propose an original type diet, by promoting raw products and not cooked products, unlike certain conventional medical practices, as soon as a lull of inflammation of the intestinal walls will allow it. The patient will have to adapt in a 1st step and select what is most easily passed. It is a question here of adopting a coordinated approach: to calm the exacerbated sensitivity, then orient the type of food at the 1st stage of the remission to then gradually increase the tolerance of the intestinal walls.
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Intestinal permeability (leaky gut)
In Crohn's disease there is a mechanism similar to that of colitis, but more complex. The Crohn’s evolves frequently by successive thrusts, separated by sometimes complete, often incomplete remissions.
Before speaking in more details of Crohn's disease, I need to highlight a common point between Crohn and IBS: leaky gut.
Zonulin, a marker of intestinal permeability
Zonulin is a protein that regulates the permeability of the intestinal wall by acting on the tight junctions between the cells. (1) Its role is to allow the passage of certain molecules necessary for the body, but to block undesirable substances such as bacteria or toxins. However, zonulin can be disturbed by genetic, environmental or food factors, which leads to an increase in intestinal permeability and stimulation of the immune system.

Among the foods that can increase zonulin production and therefore promote intestinal hyperpermeability, we find in particular (2):

• Casein (milk protein)
• Gliadin (gluten)
• Potatoes, especially young potatoes, or potatoes in shirts.
• Peppers
• Tomatoes
• Lectins (proteins present in legumes, cereals, shell fruits, etc.)
It is therefore advisable to avoid or limit these foods if one suffers from excessive intestinal permeability. There are also zeolite-based food supplements that can help restore the balance of the intestinal wall and eliminate harmful substances.
Beneficial foods and substances

• The butyrate
  The butyrate, a short chain fatty acid, has beneficial effects on the health of the colon, strengthening the intestinal barrier, modulating the immune system and preventing inflammation. The indicated dosage of butyric acid is on average 300 to 600 mg / day in a 3-month cure. Butyrate is found in appropriate quantities (> 3 mg / 100 gr) in the butter / ghee. See julienvenesson.fr later to deepen "sensitivity" to gluten, endocrine disruptors and associated pathologies, such as neurodegenerative diseases (MS, depression, autism, hyperactivity, etc.). + an overview of nutraceutics.
  Practical question
  In the event of inflamed intestinal walls (IBD), apart from the curcumin and lemon balm (Melissa officinalis), what could calm the irritation of the intestinal walls to make it possible to ingest mixed sweet fibers (shaker) with cooked foods? And not a classic NSAID, which will not extend the taking, if necessary.
• Zeolite
  Zeolite is a natural mineral that has detoxifying and anti-inflammatory properties. It can help strengthen the intestinal wall and reduce intestinal hyperpermeability, which is linked to many chronic diseases (3).
• Homeopathy
  There are several homeopathic remedies that can relieve abdominal pain, diarrhea, bloody stools or spasms related to MICI. Note that we are not trying to stop the transit but to modulate it because it is necessary to let out the circulating toxins. For example, in case of cramps with spasms, Colocynthis 4 hp (if the pain improves by being folded in half or with a hot water bottle) or Dioscorea villosa 5 hp (if the pain is improving while hiding back, improved pain in extension and walking, or leaning back).
  Sources et Références

1. Zonuline – définition & rôle
   fr.wikipedia.org
2. Aliments favorisant la production de zonuline
   santedigestion.com
   labo-barla.eu
   carolinenaturopathe.ca
3. La zéolithe
   https://www.biogena.com/fr-FR/savoir/zeolithe.html

To be continued on next page