ENDOMETRIOSIS
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@FTMarinetti Progest-E is undoubtedly the best way to go. Was she on birth control? There's a genuine epidemic of it nowadays.
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@FTMarinetti I would 2nd progest-E or take a vitamin E supplement and progestene.
Vitamin E supplement is under-rated. -
@CO3 She wasn't on birth control before diagnosis, now the doctors put her on it.
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@FTMarinetti Incredible.
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@CO3 It truly is. Problem is she really trusts her doctors, so I wouldn't even know how to approach the subject
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@CO3 I know this thread is old but I hope you see this. I was skimming this textbook "Yen & Jaffe's Reproductive Endocrinology Physiology, -- Jerome F Strauss, Robert L_ Barbieri, Anuja Dokras, Carmen" and I found this talking about endometriosis:
"Endometriosis is resistant to the effects of progesterone because of a deficiency of progesterone receptor (PR) in this tissue. In fact, endometriotic tissue produces large amounts of progesterone locally, which is consistent with PR deficiency or progesterone resistance."
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@FTMarinetti I can't find that book online, but there's the idea that progestins "act on target progesterone receptors" and therefore progestins have the same mechanism as progesterone. This is absolutely not the case -- there is an enormous difference between progestin and progesterone. When progestins don't work, they just say that there's no receptors there or you're "resistant" to a hormone; it couldn't possibly be that progestin (synthetic progesterone) simply doesn't work like natural progesterone, or that the idea of receptors is faulty. I wouldn't be surprised if that textbook is following that exact logic.
Ray said that with endometriosis there's a loop of inflammation between estrogen, prostaglandins, and aromatase. No PUFA, aspirin, vitamin B3, thyroid and progest-e all would stop prostaglandins, inflammation, FFA release and support progesterone production to oppose estrogen. Things like OJ and milk eggs should be in the diet.
I remember reading someone's gf swearing by a vitamin E gelatin capsule vaginally before bed really helping too, which makes sense since it's anti-estrogenic. I'd try progest-e topically at the very least.
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@izkrov Here is the book if you want, https://annas-archive.org/md5/a4c9184b1227cf01164abfe5b720f446. It0s quite heavy so it takes a while to download.
If I got your point correctly, you're saying that even if the area is resistant to progesterone, stopping estrogen imbalancein the whole body would help?
BTW, here's the full paragraph where the excerpt was from, I think it distinguishes between progestins and progesterone.
Thank you for the response
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@FTMarinetti I don't think an area can be resistant to progesterone, especially when one of the main mechanisms of progesterone is to oppose estrogen. I was looking somewhere to see if Gilbert Ling made any mention of the difference in muscle contraction disallowing progesterone, but it doesn't make sense to me. All I found was the usual difference in exchanging sodium/potassium ions.
It may be concluded, then, that whatever the assumed proportional weight of the endometrium may be, the estrogen endometrium always contains more Na and less K than the progesterone endometrium.
It may be concluded, then, that progesterone muscles have a higher intracellular Na concentration and a lower intracellular K concentration than estrogen muscle.
There's seemingly less contractions in endometriosis as well, probably a cause of the estrogen. I imagine there's a greater generality about the resting, high energy state maintaining sodium which allows for more contractions that hasn't clicked in my head yet.
I've seen some women say progest-e wasn't enough. I think they should just take a megadose or do consistent topical application, but even then yeah just glucose metabolism over burning fat/ taking thyroid and eating well/aspirin truly ought to fix it.
And I think the concept of receptors is what a computer programmer would come up with in regards to how a breathing organism works. Just a convenient explanation attempting to describe something and it "just works" most of the time. But yeah breaking the cascade of effects that estrogen has (prostaglandins, inflammation, then aromatase making more estrogen) is crucial, on a systemic level.
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I had a work friend several years ago who had endometriosis so bad the doctor said she'd never give birth. She left for a different job but surprised me at work later on that she had conceived! She was using 100mg Prometrium, which is sort of amazing because it has tons of junk like peanut oil and titanium oxide but the progesterone itself was still that powerful. She implied she used it vaginally but I was caught off guard about the whole thing and didn't ask for certain.