Calcium regulation and Thyroid inquiry

[Kat]

Hi! I am curious if anyone has experience with looking at hyperthyroidism and osteoporosis? I have been looking into calcium metabolism and thyroid function to try and identify where a healing opportunity may be in an individual to get balance back to thyroid and thus calcium levels. It seems to me that supporting Ca regulation with K2 M4 would be beneficial, taking molecular hydrogen or MB to help with oxidative stress that may be occurring from TPO activation, and taking progesterone and DHEA to help with possible hormonal imbalances to counteract estrogen and cortisol which I would assume to be elevated in such a condition. This would have to come along with a diet that supports bioenergetic metabolism of course first and foremost. Does anyone have any thoughts on this? Is there a mechanism I should be aware of or relationship that could be involved here that would also be clear to address (I know PTH would also cause Ca levels to become high but addressing the cortisol and estrogen would likely help to support proper PTH balance?). Thanks for anyone who has thoughts on this!

[LucH]

Hi,
What about your vitamin D intake, there is interaction between the liposoluble vitamins.
And PTH in influenced by ca absorption. 850 mg Ca is optimal (depending on the acido-basic balance).
Here is some info to optimize assimilation.
*) Vitamins A, D, E & K – How much lipids do we need to absorb vitamins A D E?
http://suppversity.blogspot.be/2014/05/vitamin-d-e-k-how-much-and-what-type-of.html
Vitamin A (retinol) + beta-carotene : 3 to 5 g.
Source: A Fat D-Ficiency
http://suppversity.blogspot.be/2011/12/fat-d-ficiency-do-you-really-need-more.html
Vitamin E: 3 g but a PUFA-diet exhausts toco- and trienols (latent inflammation).
Vitamin K (K1 and K2): 35 g
The quantity of phylloquinone (K1) which enters your blood circulation will be reduced by around 70% if you eat your spinach without a supply of fat (Gijsbers, 1996). The absorption of K2 is 3 times larger with 35 g of lipids in the meal than with 20 g. 6 x less with 8.8 g of FA. (Uematsu et al. 1996). However 18-20g and 12-15g of PUFA are consumed daily by the American man and woman (Kris-Eheton, 2000).
Vitamin D : It is the type of fat that will determine the degree of assimilation. Oil-rich in PUFA inhibit the absorption of 25oHD vitamin. (Niramitmahapanya et al. 2011). An oil with an AGMI ratio: AGPI > 1, like sunflower or soybeans, is deleterious.
Caution: If you have a high supply of PUFA (omega-3 supplementation or oilseed consumption, with the exception of macadamia nuts which are very rich in MUFA), the blood rate of Vit D and E will often be very low because these 2 vitamins also have an anti-inflammatory action and will therefore be hijacked / diverted from their use as hormones. Details on my forum (in French, but with links in in English):
http://mirzoune-ciboulette.forumactif.org/t1357-vitamines-liposolubles-et-matiere-grasse-ratio#15157
*) Synergy effect with vitamin E
“Vitamin C regenerates vitamin E and vitamin E protects β-carotene, helped in this by polyphenols. In the event of β-carotene supplementation, vitamin C regenerates vitamin E and β-carotene, and β-carotene seems to protect vitamin E without really explaining this phenomenon "(1)
Savings effect
Vitamin E is not just a vitamin. Vitamin C makes it possible to recycle oxidized vitamin E and thus prolong its lifespan. The same goes with glutathione which is thus saved for other more useful functions (detox). Glutathion is our antioxidant master. Vitamin E protects against the deleterious effects of polyunsaturated fatty acids when the latter are in excess. And it is quickly done!

1. John Libbey Eurotext - Anti-oxydants d’origine alimentaire : diversité, modes d’action anti-oxydante, interactions. Auteur : Claude Louis Léger.
2. Daniel Raederstorff et al. Br J Nutr. 2015. doi: 10.1017/S000711451500272X
   => 20 mg Vit E for 10 gr PUFA.

Factors that facilitate or counter the absorption of vitamin D3
http://mirzoune-ciboulette.forumactif.org/t1664-absorption-de-la-vitamine-d-insuffisante#20619

• A Magnesium intake neither too high nor too low (RDA Mg: 360 and 420 mg depending on the sex f / m) is favorable. An excess of Mg will thwart the absorption of vitamin D3.
• Mono-unsaturated fatty acids facilitate the absorption of vitamin D (olive, avocado, macadamia, for example). Saturated fatty acids (SFA) are probably neutral, at this level. But since these SFA’s contribute to the stability of the membranes, we should take care to have a 50/50 ratio between SFA and MUFA. And as few PUFA as what is necessary for metabolism (1 % = 22 gr. It is already calculated widely. 4 % is the level not to be over. 6 % is deleterious). (Perfect health diet. Jaminet).

[Emilia]

@LucH thank you for the interesting read. In my interactions with numerous cancer patients, a prevalent choice among them for oils is EVOO. It is imperative to be cautious when using EVOO for cooking due to its low smoke point. This caution emphasises the potential adverse effects of using it on its own. Despite the undisclosed specifics concerning their daily diets and environmental conditions, it remains intriguing that a significant number of these individuals opt solely for EVOO.