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Low androsterone, androstenedione, estradiol, DHT, cortisol, DHEA. How do I fix these?

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  • D
    doifus
    last edited by Jun 24, 2024, 3:28 PM

    Hi all,

    I recently got a tissue analysis of my steroid levels and am quite shocked to see the results.

    Many of my androgens (androsterone, DHT, epitestosterone) are below detection limits, while my androstenedione, DHEA, cortisol, and estradiol are quite low.

    I supplement progesterone (5-10mg) every so often, so my progesterone levels were quite high. It seems my tissues are holding on to as much as they can.

    Despite my testosterone being normal and estradiol being low, the ratios of androgens to estrogens are low enough to suggest estrogen dominance. Moreover, the ratio of androstenedione to DHEA (low) suggests 3-beta HSD inactivity.

    I cannot find anything on the internet on how to correct these issues. Where would you start?

    C 1 Reply Last reply Jun 25, 2024, 7:36 AM Reply Quote 0
    • C
      cs3000 @doifus
      last edited by cs3000 Jun 25, 2024, 8:13 AM Jun 25, 2024, 7:36 AM

      @doifus hi i would fix thyroid function assuming its low & eat some vitamin A as this is the beginning of the process for generating them, thyroid signals steroidogenesis. you could stop the progesterone as its skewed & replace with pregnenolone as this is the next step. u could add some dhea which converts to androgens

      D C 2 Replies Last reply Jun 25, 2024, 2:33 PM Reply Quote 0
      • D
        doifus @cs3000
        last edited by Jun 25, 2024, 2:33 PM

        @cs3000 Thanks. I think DHEA and pregnenolone make sense. I will definitely get my thyroid checked in the near future. I currently supplement Estroban (containing ADEK) and B vitamins.
        I have also stopped the progesterone. I think it may be combatting the androgens. The problem is I like it so much – almost instantly relives tension headaches and helps me relax. I guess that's a sign that I need to address the underlying issues.

        C 1 Reply Last reply Jun 26, 2024, 8:16 AM Reply Quote 0
        • C
          cs3000 @cs3000
          last edited by cs3000 Jun 26, 2024, 8:15 AM Jun 26, 2024, 8:15 AM

          This post is deleted!
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          • C
            cs3000 @doifus
            last edited by Jun 26, 2024, 8:16 AM

            @doifus i was gonna ask if you get migraines actually (high incidence of low pregenolone in ppl who get migraines, and either testosterone or progesterone can be helpful, or pregnenolone id imagine which some of can go to progesterone). but yeh thyroid is 1 foundation

            D 1 Reply Last reply Jun 26, 2024, 3:27 PM Reply Quote 0
            • D
              doifus @cs3000
              last edited by Jun 26, 2024, 3:27 PM

              @cs3000 What's weird is that I don't notice any symptoms. Maybe the progesterone is saving me from symptoms that I otherwise couldn't help but notice.
              Thanks for your reply.

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