Lidocaine
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If someone has a 5% bottle of lidocaine, how would you figure out the amount to give your rat if you wanted to try 50-100 mg?
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Where do you source the Lidocaine if it's USP?
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Interestingly they also sell procaine, which is what I think Ray liked more than even lidocaine. Might be something worth trying next time. But Iv'e only ever taken lidocaine like 3 times, so I don't really have much to gauge the procaine by. Lidocaine kinda felt like cyproheptadine to me, definitely has a anti-histamine like quality to it.
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@Mulloch94 said in Lidocaine:
Interestingly they also sell procaine, which is what I think Ray liked more than even lidocaine. Might be something worth trying next time. But Iv'e only ever taken lidocaine like 3 times, so I don't really have much to gauge the procaine by. Lidocaine kinda felt like cyproheptadine to me, definitely has a anti-histamine like quality to it.
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Thank you! I'll definitely look into it
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Beware that both lidocaine and procaine exert agonism at (peripheral) CRH receptors.
Also, they both significantly inhibit osteoblasts. Procaine does that right away and this is very relevant already after a week of use. I.e. teeth can suddenly become wobbly in the weeks afterwards. Lidocaine at first promotes them (50-70mg max?) but then also drastically inhibits beyond low doses.
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@CrumblingCookie Were you taking it for anti aging or pain?
I was interesting in the reversal of dna methylation. I wouldn't want to risk tooth loss for any experiment.
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@CrumblingCookie said in Lidocaine:
Beware that both lidocaine and procaine exert agonism at (peripheral) CRH receptors.
Also, they both significantly inhibit osteoblasts. Procaine does that right away and this is very relevant already after a week of use. I.e. teeth can suddenly become wobbly in the weeks afterwards. Lidocaine at first promotes them (50-70mg max?) but then also drastically inhibits beyond low doses.
I think 70mg is way too high. I don't know what Peat said was ideal but I feel a very potent effect on just 20mg. Probably also not something worth using in a long-term stack either, only sporadically when needed. Just my opinion. But it's a lot like naltrexone, except maybe worse, because naltrexone has conflicting reports about it's liver toxic effects. Lidocaine doesn't, and reports seem to agree pretty definitively it can be hepatotoxic when used in high dosages or over long periods.
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@Insomniac said in Lidocaine:
Were you taking it for anti aging or pain?
Against pain, for which it was mildly effective and good for sleep, too, but only initially. The mind-numbing effect it initially had was also a little scary at first and felt somewhat similar to that drag into an empty black hole of a propofol injection. However, I later didn't feel that anymore.
The positive effects waned or shifted to higher doses by about every other day. I had started at 20mg lidocaine p.o. and whilst I took up to 200mg eventually, I felt no more benefit above 60mg or 80mg. Beyond that it turned to enhanced pains and also immune suppression by both lidocaine or procaine. The procaine I didn't like even at lower doses.To take (ox)carbazepine along with these substances would prevent their action on CRH receptors but it's possible that the latter is essential to their overall effects. Such a combination would perhaps render them mainly useless.
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@CrumblingCookie This is the first detailed account of a lidocaine experience I've ever seen. It's very much appreciated. I've wondered about it for years.
It's also the first I've heard about crh possibly being involved in it's mechanism. Thanks for the education.
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@Mulloch94 said in Lidocaine:
@CrumblingCookie said in Lidocaine:
I think 70mg is way too high. I don't know what Peat said was ideal but I feel a very potent effect on just 20mg. Probably also not something worth using in a long-term stack either, only sporadically when needed. Just my opinion. But it's a lot like naltrexone, except maybe worse, because naltrexone has conflicting reports about it's liver toxic effects. Lidocaine doesn't, and reports seem to agree pretty definitively it can be hepatotoxic when used in high dosages or over long periods.
I don't know about long term lidocaine but people have taken Procaine/ Gerovital H3 long term for anti-aging.