Which antibiotics for gut issues and chronic fatigue?
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@skywxlker Bump. Similar problem here. I've used many different antibiotics, varying dosages, never actually helped thus far, but the show must go on.
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If the antibiotics don't help:
-Big doses of pregnenolone (300mg+) can really help with intestinal problems. Here's a story from the 'other' forum:
"Been 2 years and I’m on low dose TRT since but still never felt right. Low body temps like 96.5 . Pain everywhere. My youth hormones plummeted also , but I didn’t know to check them until Ray. I played around w all 3 in average doses and nothing changed really. The past week I’ve supplemented 300mg pregnenolone daily and good lord.**
Every single blood marker improved dramatically. I’m now pooping 3 times a day. No more bloat. My TMJ and head pressure disappeared. Colors are brighter. Multiple ppl have commented on my skin. Temps are now at 98.6+ Even in morning. extreme blood sugar issues have stopped."
-topical vitamin D in a big dose can really relax a painful gut. Try it orally as well.
-the Lisuride+cyproheptadine combination
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@skywxlker I would suggest looking into probiotics as an alternative. Antibiotics are likely to kill good bacteria along with the bad, inevitably leading similar ratios to regrow and cause the same problems all over again. Some independent researchers have studied gut biome transplants that introduce samples of healthy gut culture into a diseased gut, with promising results.
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Interesting. I’ve just started to incorporate large doses of preg and progest. I’ve taken 100mg of preg for a few weeks but it didn’t help much, but I’m looking at taking .5-1g. My issues are quite severe.
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Yeah dude it sucks. Have you tried hormones like preg or probiotics? Did you gradually worsen or was it a sudden onset?
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@skywxlker I've tried lots of progesterone, other drugs acting on hormones/neurotransmitters. Thinking of playing with some more androgens, but I don't think it's going to help the digestive problem. Only used a little bit of pregnenolone because I'm skeptical of the quality of what's available on the market. I've tried some probiotics but I've never really went too deep into that. But nothing thus far has ever changed how my GI feels whatsoever.
I don't know if it was sudden or a gradual onset. I've had this problem for many, many years. It had to have started when I was a child, because I don't remember feeling any decline or sudden deterioration of my digestive function. It must have started going downhill further back than the scope of my memory. I can't remember a time where I wasn't plagued by this.
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Health Natura’s Pregnenolone has given me zero bad side effects as compared to this other cheap brand. If that’s worth anything.
My issues have also been plaguing me for a while. But seem to be exacerbated by covid infections and tweaking my diet too much.
Kefir has helped me. I stopped for a year and my gut health got worse. So I recently added it back in and it’s been going better.
BPC-157 oral tablets have also helped me.
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@skywxlker intestinal microbiota transplantation can help you. I cured Crohn's disease with peating and a liquid diet.
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@Fructose said in Which antibiotics for gut issues and chronic fatigue?:
a liquid diet.
Yep, Ray's metabolic emergency diet of OJ and milk is a good option for people with gut disorders.
It's pretty drastic but people might need a multi pronged approach for stubborn gut stuff- diet as well as supplements.
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Doxycycline is excellent, if it still doesn't work then gum turpentine to initiate the final solution
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Have you tried well cooked white button mushrooms with olive oil?
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@skywxlker I lived with IBS, leaky gut, SIBO and also CFS for many years. All of these problems resolved for me via taking high dose thiamine. I uses thiamine hcl rather than TTFD because I couldn't tolerate the TTFD because my glutathione level was low because of high oxidative stress, which has also resolved via the high dose thiamine hcl.
suggested reading:
https://www.hormonesmatter.com/tag/sibo/
https://www.hormonesmatter.com/thiamine-fibromyalgia-cfs-me-chronic-lyme-sibo/ -
interesting. I have high dosed TTFD and benfotiamine but never thiamine HCL. I will have to give it a try
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never together but seperately yes. honestly that sounds quite horrid lol. maybe it's my gut taking though...
I have always disliked mushrooms. olive oil is good though.
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@skywxlker Read through Dr. Costantini's information about the amount of oral thiamine hcl that is needed to equal one 100mg thiamine hcl injection. Because thiamine hcl's intestinal absorption rate is so low when taken orally, a much higher dose is needed than if taking TTFD or benfotiamine. I spent 4 months working up to my "optimum" dose (from 300-350 mg divided into 2 doses daily to 1 gram thiamine hcl 2Xday).
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I too have been dealing with chronic gastrointestinal issues, and our symptoms are exactly the same. I'm currently on sabbatical and desperately need some symptom relief before returning to my professional work.
To achieve that, I'm preparing to self-treat with a two-week round of doxycycline at 50-100mg/day, administered concurrently with nystatin at 500,000 units/day; dosage and duration are subject to change based on my reaction to the drugs. I'll update this thread or another with my experience.
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@mostlylurking thanks. will do.
I didn't know TTFD would tank glutathione. I did get benefits at first and I believe some of these benfits were even from the sulphur. But then things became stagnant. and increasing the dose didn't seem to do anything more but to raise my heart rate.
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@cornwallis God speed brother.
How long have you had these issues and do you know if anything potentially triggered the onset?
Mine got worse after Peating for a year. I cut out kefir and starches, ate tons of simpler carbs. Then I caught covid 4 months ago and my issues became 10 out of 10 problematic.
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@skywxlker said in Which antibiotics for gut issues and chronic fatigue?:
I didn't know TTFD would tank glutathione. I did get benefits at first and I believe some of these benfits were even from the sulphur. But then things became stagnant. and increasing the dose didn't seem to do anything more but to raise my heart rate.
I learned about the glutathione issue from Elliot Overton.
Elliot also mentions the glutathione issue in a video on youtube. In the video he suggests that if your glutathione level is low you can take thiamine hcl for a while to normalize your glutathione level. So I used thiamine hcl and within a few months, my glutathione level achieved normal levels for the first time in many years. I chose to stick with thiamine hcl as I do so well on it. My glutathione level had tanked many years ago because of my high oxidative stress caused by my mercury toxicity.
In addition to taking high dose thiamine hcl, I also take magnesium glycinate (3100mg, divided into 2 doses each day), niacinamide (100mg, 4Xday), and 100mg of riboflavin (100mg, 4Xday). Elliot Overton et.al. have said that magnesium is needed to work with thiamine. Elliot has also said that niacinamide and riboflavin also fill important rolls in the process.
Ray Peat on magnesium, written work
Ray Peat on magnesium, interviews
Ray Peat on niacinamide, written work
Ray Peat on niacinamide, interviews
Ray Peat on riboflavin, written work
Ray Peat on riboflavin, interviewsI was unable to tolerate higher doses (greater than 250mg) of magnesium glycinate until I was high dosing the thiamine hcl. Thiamine improves your tolerance for magnesium.
Here's more information about magnesium.
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@mostlylurking thank you. this is very helpful.
I have been under lots of stress, I'm sure my glutathione is in poor status.
I also felt better using B2, and B3 along with thiamine. and I do feel that the thiamine threw off my Magnesium metabolism. I often don't know if I should take more or less.
