@Appa Well said. Very much lines up with my experience and I couldn't help but notice the similarities with SSRI's on mood, behavior, sleep, appetite.

It turns you into a zombie. Cypro made me sleep, hungry, and foggy. Never liked it.

Now I have these unwanted side effects long term... that I'm thinking of correcting with a serotonin agonist.

Any recommendations for an agonist?

someone help me out. why is antagonizing receptors a good thing if it ends up increasing serotonin overtime?

E.g. cypro blocks serotonin which causes it to increase in the brain.

SSRI's do the same thing. blocking its uptake by the receptor.

also it appears the Peaty substance "Emodin" is a natural serotonin AGONIST. As we all know this stuff is great for the gut, overall wellbeing, and according to this effective against alzheimers, TnF, inflamation in the brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450432/

what gives Peaters?

to antagonize or agonize serotonin?

@Orindere ground beef, eggs, milk, oj, apple juice, sometimes liver and shrimp, sardines, collagen, kefir, chicken sometimes, honey, and sometimes potatoes

I have tried a host of mineral supplements, its hard to tell if they help.

Trazadone, cypro, and 10 meo harmalan all make me insatiably hungry. I'm not enjoying this at all.

Its been 5 months since I took them and I'm still so damn hungry.

I have some metabolic issues and maybe it's my body's attempt to become anabolic but its not working well. I'm gaining weight too fast and I'm having trouble getting in enough food. I feel sick if I don't eat.

I have mecfs and long covid so maybe I'm really malnourished? I have yet to find nutritional supplements that reduce the hunger. ie b vitamins or minerals. It kind of works but I think whatever I did to my brain was too much. I think I want a serotonin agonist to control the appetite. And get back to my baseline. Could my serotonin just have gone haywire?

Also don't serotonin antagonists increase serotonin and make it last longer in the brain? I thought that wasn't peaty. So would I need something that breaksdown serotonin? or a serotonin agonist?

What should I do?

thanks

@mostlylurking I'll do my best to do this.

@mostlylurking

I'm taking mag glycinate. 800-1200mg across the day.

I think I will switch back to hcl version. I just took two grams. The week I took it did solve my most pertininant issues. I shouldn't have stopped it so soon.

do you foresee any issues with mineral deficiencies? Also why not b7? is that just a personal thing? and do you think that the thiamine megadose will fill in that gap?

I spoke to ER and they said they couldn't do anything except that it does appear I have metabolic syndrome. Likely deficiencies, malabsorption, glycogen storage disease, etc.

They are going to get the hospital to talk to my doctor asap.

@izkrov yeah probably except I've tried thyroid and it seems to backfire. Also excessively hungry. My thyroid markers were within normal. TSH like 1.4.

It just made me feel wired. Even small doses

@mostlylurking thank you.

thoughts on TTFD? it does seem to work for me...

My magnesium is 400mg elemental weight. So that means I'm taking like 1200mg because I would take three per day.

thoughts on upping B3 to 2-3 grams?

I'm going to up TTFD to possibly 1000/day. I'm like 500mg per day. I do feel slight effects.

When I was taking thiamine HCL, I took 10 grams actually to relieve my symptoms. But after 3 days of that I found that 2,3 grams was doing the trick. You are probably right, I think I stopped prematurely.

@izkrov No I dont take aspirin. I was for a long time but I dont feel much from it. should I reintroduce?
I take magnesium glycinate.

I think I am wasting. All my nutrients going down the drain. mecfs people are serious hypothyroid and severe folks succumb to malnutrtion/wasting.

@skywxlker dang it guys. I do think I'm wasting. Eating so much to stop the pain and adrenaline. If I dont eat something bad will happen.
I'm still very overweight though... what does that mean? Its like I'm starving from within.

Going to up the niacinamide. and everything else too a bit.