Posts made by skywxlker

@Appa Well said. Very much lines up with my experience and I couldn't help but notice the similarities with SSRI's on mood, behavior, sleep, appetite.

It turns you into a zombie. Cypro made me sleep, hungry, and foggy. Never liked it.

Now I have these unwanted side effects long term... that I'm thinking of correcting with a serotonin agonist.

Any recommendations for an agonist?

someone help me out. why is antagonizing receptors a good thing if it ends up increasing serotonin overtime?

E.g. cypro blocks serotonin which causes it to increase in the brain.

SSRI's do the same thing. blocking its uptake by the receptor.

also it appears the Peaty substance "Emodin" is a natural serotonin AGONIST. As we all know this stuff is great for the gut, overall wellbeing, and according to this effective against alzheimers, TnF, inflamation in the brain.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8450432/

what gives Peaters?

to antagonize or agonize serotonin?

@Orindere ground beef, eggs, milk, oj, apple juice, sometimes liver and shrimp, sardines, collagen, kefir, chicken sometimes, honey, and sometimes potatoes

I have tried a host of mineral supplements, its hard to tell if they help.

Trazadone, cypro, and 10 meo harmalan all make me insatiably hungry. I'm not enjoying this at all.

Its been 5 months since I took them and I'm still so damn hungry.

I have some metabolic issues and maybe it's my body's attempt to become anabolic but its not working well. I'm gaining weight too fast and I'm having trouble getting in enough food. I feel sick if I don't eat.

I have mecfs and long covid so maybe I'm really malnourished? I have yet to find nutritional supplements that reduce the hunger. ie b vitamins or minerals. It kind of works but I think whatever I did to my brain was too much. I think I want a serotonin agonist to control the appetite. And get back to my baseline. Could my serotonin just have gone haywire?

Also don't serotonin antagonists increase serotonin and make it last longer in the brain? I thought that wasn't peaty. So would I need something that breaksdown serotonin? or a serotonin agonist?

What should I do?

thanks

@mostlylurking I'll do my best to do this.

@mostlylurking

I'm taking mag glycinate. 800-1200mg across the day.

I think I will switch back to hcl version. I just took two grams. The week I took it did solve my most pertininant issues. I shouldn't have stopped it so soon.

do you foresee any issues with mineral deficiencies? Also why not b7? is that just a personal thing? and do you think that the thiamine megadose will fill in that gap?

I spoke to ER and they said they couldn't do anything except that it does appear I have metabolic syndrome. Likely deficiencies, malabsorption, glycogen storage disease, etc.

They are going to get the hospital to talk to my doctor asap.

@izkrov yeah probably except I've tried thyroid and it seems to backfire. Also excessively hungry. My thyroid markers were within normal. TSH like 1.4.

It just made me feel wired. Even small doses

@mostlylurking thank you.

thoughts on TTFD? it does seem to work for me...

My magnesium is 400mg elemental weight. So that means I'm taking like 1200mg because I would take three per day.

thoughts on upping B3 to 2-3 grams?

I'm going to up TTFD to possibly 1000/day. I'm like 500mg per day. I do feel slight effects.

When I was taking thiamine HCL, I took 10 grams actually to relieve my symptoms. But after 3 days of that I found that 2,3 grams was doing the trick. You are probably right, I think I stopped prematurely.

@izkrov No I dont take aspirin. I was for a long time but I dont feel much from it. should I reintroduce?
I take magnesium glycinate.

I think I am wasting. All my nutrients going down the drain. mecfs people are serious hypothyroid and severe folks succumb to malnutrtion/wasting.

@skywxlker dang it guys. I do think I'm wasting. Eating so much to stop the pain and adrenaline. If I dont eat something bad will happen.
I'm still very overweight though... what does that mean? Its like I'm starving from within.

Going to up the niacinamide. and everything else too a bit.

@skywxlker I was doing a low salt diet to manage my bp. salt would skyrocket my bp but I have been introducing it again because it doesnt seem to go that high. I'm taking magnesium like 400mg per day. I recall higher doses gave me diarrhea. eating like 5000 calories per day. I do feel a noticable shift, when I take b vitamins but tend to swing too much. and I absolutely cannot miss a meal.

I think I'm starving from withing. utilizing aminos for fuel.

I read that b vitamins can prevent wasting syndrome. so again, I might double up on B3, B7 and more B2.

idk wtf is wrong. my health is a disaster. doctors don't know shit.

background: I have had mecfs 2.5 years then Long Covid for 5 months starting in October. I have been trying various things to get better regarding Ray Peat based principles. Anyway I am showing some refeeding syndrome-like issues.

I feel incredibly hungry these days! I'm eating tons of protein and carbs every two to three hours to keep severe pain away. Overall like 200g of protein and 800g of carbs despite being sedentary.

So long story short I had mecfs two years. I was very severe for like 4 months until trazadone gave me a boost and I became moderate severe. Except it made me sooo hungry. Eating everything in sight every 2 or three hours. eventually I gained like 80lbs in a few months until finally the hunger subsided and the weight fell off. So now I have so have moderate CFS and I am mostly couchbound and housebound.

fast forward a year and a half. I get covid. (for that two years I was trying a bunch of supplements making some decent progress but not much.)

After some rough covid, I get super hungry again!! eating and eating. if I don't I eat I get severe crash like symptoms. I also now have tachcardia, high blood pressure, chest tightness. non stop eating and gaining weight like crazy. activity levels are very poor now. With mecfs, we have serious metabolic issues, possibly malnutrition.

In desperation I started taking b vitamins and they helped! along with high doses of progesterone. like 100mg topical. and it heals my heart problems, tachy, bp, and helps with hunger and lactate. and I was stable for two months or so.

but I run into problems when I start benfotiamine. It gives me high blood pressure and tachycardia. plus the hunger comes back like crazy. I get off of it but then those issues come back. so again being in so much pain and malaise if I dont eat. I megadose thiamine hcl and it helps me a ton. I took like 5 grams a day for a week and it helps out everything again. I

I slowly reduce the thiamine in the span of a week and introduce other b vitamins.

still have my symptoms under control. feel massively better with

100mg TTFD
10mg B2. (dont react well to it)
200mg niacinamide
100mg B5
50mg B6
40mg Biotin

(4-5/day after a meal)

and sometimes B9, B2, B12. I noticed I felt worse on these....
started these last week after having issues with benfo, and megadosing thiamine hcl in early February.

whole time I'm too sick to see my doctor. and my appointments keep getting rescheduled

now I'm doing good for a few days but I'm sooo hungry!!! but at least symptoms are gone! and I dont feel like I'm dying (people with very severe mecfs know what I'm talking about).
Imo mecfs is severe malnutrtion akin to starvation. We begin to use protein as fuel instead of glucose or even fatty acids.

Now last night some major issues. I accidentally doze off and forget to eat protein. I'm jolted awake and adrenaline surges through my body. I'm so hungry. I chug some juice, honey and start eating beef.

But I feel awful symptoms the whole time. severe panic, hunger, shaking. I even have loose stools from it. after stuffing my face. and still not feeling so good, I take my b vitamins and progesterone and finally after a few hours it calms down. this was 5 hours ago and I'm starting to feel kind of bad again. so I need to eat!

I'm monitoring my glucose every hour.

Idk what to do, what I've done to myself.... I was damned if I do, damned if I dont kind of thing. because that endless hunger post covid wouldnt stop and those heart issues were so bad. I was going to crash or end up weighing 300 lbs as I gained like 70lbs in two months.

Its my body starving from within.
I'm afraid of what is happening. I'm trying to reach my doctor.

I dont know if hospitals will help. I feel like I know how much food to eat and what kind and when. they obviously dont understand much about MEcfs.

I was doing good til I missed a meal! whats strange is that I'm really good for like a few hours then the hunger hits but my symptoms are gone. if I eat, I'm kind of good again. this time feels worse than I crash bevause of all the adrenaline. I'm afraid its refeeding like syndrome.

only thing I can add is that I was taking cyproheptadine during covid which works a lot like trazadone!

I also took progesterone during covid and I think it saved my life. and it continues today. I have taken b vitamins without it and it doesnt work. I have tried progesterone only and it doesnt work.

while on these b vitamins and progesterone, I have had moments where I feel amazing. even since before I got covid with moderate mecfs. All my symptoms gone. I felt clear, and without fatigue for the first time ever. I have never felt so relaxed and yet so energized. it comes in moments.

but its been a rollercoaster when I dont eat enough or mess up.

what do I do?

my options:

1. hit the gas on b vitamins and eat a fuck ton. like 200g of protein and 1000g of carbs just to not crash. never ever dare skip a meal. lots of hunger, less lactate.

2. stop everything, and keep stuffing my face except I'm burning protein and getting super fat. but at least not risking refeeding syndrome. but also possibly risk a crash that will permanently disable me with mecfs. or worse. lots of hunger, high lactate.

my theory is that number one is risky because I could have malnutrtion and these swings do so much damage. Plus showing some partial refeeding syndrome.

thinking of taking even more b vits. I have taken up to 700mg TTFD thiamine, 1500mg B3, 100mg B5, 50mg B6, 40mg B7.

Going to add B2 now also and a bit of folinic acid.

I'm seriously messed up you guys. I was almost permanently disabled with mecfs. after you become permanent, it's difficult to reintroduce nutrition.

So I'm treading water here. Both of my options are risky. My body is having difficulty find homeostasis.
I'm quite afraid of the situation I'm in.

All I know is that b vitamins have given me glimpses of good health.. Along with progesterone megadosing.

Kind of think I'm in too deep and should just double down on b vitamins. thing is, I risk mineral and nutrient imbalances. or am I?

I currently take like 500mg TTFD, 600mg niacinamide, 400mg B5, 50mg B6, 40mg B7.

Thinking of adding more B3 and B2.

also why am I so damn hungry? my theory is that serotonin antagonists do something crazy to my brain. I eat and eat and still feel hungry. Add some malnutrition or malabsorption.... so I think I have some partial, refeeding syndrome. some nutrient I'm still lacking.

I eat a ton of beef, milk. apple juice, OJ, collagen and honey. for now but sometimes eggs and potatoes.

Doctors and hospitals dont know anything do they? they will think I'm crazy.

thanks for your help.

@Ecstatic_Hamster > I lost 50lbs too in about 7 months eating mostly potatoes and milk for carbs. maybe a quarter of my carbs from honey and juice.

I initially gained like 70 lbs from taking Trazadone, a serotonin antagonist that was helping me sleep but making me ravenous. This was before I found Ray Peat.

Then finally the hunger wore off and then weight came off with minimal exertion. Just light exercise, sunlight, and potatoes.

Goes to show how complicated this is. I feel for anyone struggling with their health.

Now I'm getting fat again from Peating lol

@mostlylurking I sincerely appreciate your thorough responses and for leading me in the right direction. I will make sure to check out those resources!

anyway, yes. I am now only taking 300mg of thiamine HCl as it has become too strong. It drops my blood sugar too fast and reintroduces excess unwantrd hunger. Since I am still quite satiated from the meal before. Two weeks ago I took 5-7 grams for about 3 days and over that time span I have reduced the amount of thiamine gradually due to the large drops in blood glucose. I now take about 50mg spread throughout the day.

I might try a different form of magnesium. When my metabolism is better, I have noticed this issue with magnesium. I believe I am retaining it.

Also, last night I reduced the B5 significantly and increased niacinamide and biotin quite significantly to 1g and 45mg respectively. The results were astounding. I felt the best I have ever felt with chronic fatigue syndrome and long covid. I felt normal for the first time in years. By no means near healthy but it was an incredible feeling.

I have tried this combo of b3 and b7 not long ago. alongside thiamine ttfd. however I believe the intial megadoses of B1 helped me breakthrough bottlenecks. I also feel that B3 and B7 together are working synergystically. Because I have tried one or the other recently, without the same effects.

I also slept 7 hours straight for the first time. I always always pee at night a few times.

You were right about B5 I believe. It did make me feel worse. I'm also taking 3mg of folinic acid and 40mg B6 spread throughout the day. And a few minerals in very small doses. like selenium, manganese, molydenum, zinc, coppper. I believe these two are having positive effects. Although I am I need of testing to assess mineral status.

I am taking meticulous notes about everything I consume and feel.

Food for thought in case this anecdote would be of interest to you.

@mostlylurking thanks for the thought out reply.

I took 5g of thiamine a day for like 3 days. And slowly over the last two weeks I have become more sensitive to it. It has resolved my tachycardia, blood pressure, lactate, and stomach sensitivity to a large degree.
I was also taking small doses of the other B vitamins.
Now I am only taking 300mgs. Having gradually reduced the dose since megadosing. I took 5g spread out over the day because thats the only thing that helped! truly saved my butt.

I do take magnesium. However yesterday, just 60mg gave me diarrhea. Not sure why. It could have been something else. But this isnt the first time I had this issue with mag.

I'm so hungry for animal meat and milk. And more so when I increased B3 and B5. So I'm trying to understand if I am need of a certain nutrient or if I'm going through a refeeding like stage

I have heard that this may be some sort of refeeding thing. but I'm not sure.

I do spread my supps over the course of the day.

I think youre right about the liver and glycogen stores. I'm taking taurine now to see if that helps.

Did you take that B5 in one dose?

I start incredibly small when introducing supplements. I started with just 50mgs of B5.

I plan to do some testing to assess my health.

thanks for your help

@mostlylurking hey I have another question

So I've been megadosing B1 for the last two weeks. Everything was going well at first but now it seems that even 50mg of B1 seems to drop my blood sugar way too fast and often times makes me hungrier.

Any ideas? B1 was effective for many things. I feel much of symptoms reduced. I was also taking a b complex just to balance things out and occasionaly some minerals.

I believe I'm highly saturated at this point. I'm urged to up the niacinamide from 500mg to 1500mg. B7 from 16mg to 40mg. B5 from 250mg to 500mg.

I know it's complicated. any thoughts appreciated

@rayjeet dude keep us posted

@mostlylurking
thanks for sharing.

what was your dose?

did the cravings go away when you stopped? or slow down over time?

any idea why beef specifically?

@LinDaiyu interesting. i thought it was the potatoes. this is new data for me to work with then.

how was your experience with thiamine hcl? any other changes you noticed for better or worse?

@mostlylurking thought I replied.

but I just buy it off amazon. made by the brand "Thorne"