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    GABA administration ameliorates Sjogrens Syndrome in two different mouse models

    Bioenergetics Discussion
    sjogrens syndrome gaba
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    • cs3000C
      cs3000
      last edited by cs3000

      Sjogrens = autoimmune damage to glands that causes extreme dry mouth & eyes

      GABA helps a lot preventatively and after the damage too in this model https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8773584/

      56104138-7346-4452-912c-812fc9a5265f-image.png

      When assessed weeks later, GABA-treated mice had greater saliva and tear production, as well as quicker times to salvia flow, in both SS mouse models. {used preventatively or after symptoms}
      Given that GABA-treatment preserved saliva and tear production which are the most salient symptoms of SS and is safe for consumption, it may provide a new approach to help ameliorate SS.

      20mg / ml water female mice,
      if they drank around 5ml water,
      100mg per mouse per day , so ~4g per kg, so very high dose human equivalent 20g+ (probably not a great dose as lower can cause blood pressure changes dizziness). but here its spaced out in water

      If someone has this considering the great outcomes might be worth trying a lower dose for a few weeks to see if its helpful. 500mg is active in the body going by other study areas & a couple grams has been used for lowering seizures in humans

      Btw theres some fuckery going on with some popular supplements (idk if it was swanson or if it was the place i got it from), but one i got didnt dissolve in water (not gaba)

      "world," as a source of new perceptions
      more https://substack.com/@cs3001

      "Self-organizing systems decay only if they have assimilated inertia and — with a little support of the right kind— the centers of degeneration can become centers of regeneration"

      InsomniacI 1 Reply Last reply Reply Quote 0
      • InsomniacI
        Insomniac @cs3000
        last edited by Insomniac

        Btw theres some fuckery going on with some popular supplements, one i got didnt dissolve in water (not gaba)

        Things like this keep me up at night. How many kilos of powders from china have I eaten over the years? I don't even want to think about it. Horrifying

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