glutamine? good or bad?
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some say it heals the gut, others say it is dangerous
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@wester130 I mean it's fine but imo there isn't much use supplementing it
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@wester130 said in glutamine? good or bad?:
some say it heals the gut, others say it is dangerous
We need L-glutamine when the mucus thickness of the stomach is weak (acid painful). Not to do when suffering from dysbiosis because it feeds candida albicans.
But there is a contraindication (second case)- To rebuild the border brush
In the event of inflammation of the stomach and/or intestines, it is almost certain that L-glutamine is diverted from its objective (muscle synthesis or neuronal impact) in order to consolidate the damaged walls. It is therefore necessary to multiply the catches in the latter case. Begin slowly because it could be laxative. - Excitotoxity
A downside, however: glutamine, as part of GABA (see link below), will be transformed into glutamic acid in order to pass the blood barrier, which will make it excitatory unlike its basic form. It is therefore appropriate to add a few grams of taurine in order to moderate the excito-toxicity of glutamate and, thus, we can easily multiply the doses and increase the dosages.
GABA (2)
GABA is a brain neurotransmitter, synthesized from glutamic acid (glutamate).
In the central nervous system, there is a close collaboration and interaction between glutamine, glutamate and GABA. The stimulating action of glutamic acid (glutamate) is compensated by the calming activity of GABA. Glutamine, as an energy source in the brain, acts as a regulator of the interaction between glutamate and GABA. A balance between these 3 amino acids ensures balanced brain metabolism. GABA is the most important calming substance in our brain. GABA is the main neuromodulator or inhibitory neurotransmitter of the CNS in adults. GABA reduces the excitability of the central nervous system (CNS) and therefore has sedative, anxiolytic and muscle relaxant properties. GABA improves sleep quality (promotes deep sleep) and relaxes both the mind and body.
Taurine as a neuroprotector and moderator of excitotoxicity (3)
Taurine exerts its neuroprotective functions against glutamate-induced excitotoxicity by reducing the glutamate-induced increase of calcium levels in tissues.
Taurine also serves to maintain the structural integrity of the membrane [6], to regulate calcium binding and transport [7, 8], as an osmolyte [9, 10], neuro-modulator [11], neuro-transmitter [12–18] and neuro-protective against neurotoxicity induced by L-glutamate (L-Glu) [19, 20]. Apologies for so much!
In practice:
For 1 shake of 500 ml of spring water. Double the proportions once OK.
• Mg bisglycinate with B6, 1 dose of 2.5 gr per shake.
• Taurine 2 gr & glutamine Kyowa (1 tsp, 5 gr)
NB: Taurine must be combined with glutamine to moderate the excitatory effect. B6 is optimal to keep magnesium inside the cell.
• 10 gr collagen (2 tsp)
NB: I’d take some ghee later for butyrate (or rancid butter), 1 tsp. If problem with the stomach (leaky gut).
• Pinch of L-ascorbic acid (CAS certificate required) (0.2 gr)
How would I manage?
Prepare an infusion of the desired taste for one liter of spring water. For 2 shakes of 500 ml. For example 2 sachets with red fruits and blackcurrant.
Add a variation of 50 to 100 ml of lemon juice to limit the risk of intolerance, from time to time, to taste. Or 2 tsp of pure stevia or with erythritol. Do not overuse polyols (impact on the microbiota).
Note: I can give the reference if desired.
- To rebuild the border brush
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@LucH could lysine reduce glutamate toxicity?
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@wester130 said in glutamine? good or bad?:
could lysine reduce glutamate toxicity?
No, I won't do that.
Only useful when there is brain edema: nitric oxide is seek but it's counterproductive for wealthy persons.
Excito-toxicity is balanced with taurine and glycine. -
@LucH why is gelatin so high in glutamine?
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@wester130 said in glutamine? good or bad?:
why is gelatin so high in glutamine?
We don't use gelatin for glutamine but for collagen. Collagen is rich in glycine and proline.
Glycine is going to moderate the possible excito-toxicity of glutamate (change of glutamine into glutamate (glutamic acid) in the process of assimilation, partially).Collagène composition: Protéine 86 – 92 %
- Glycine: +/ 30 % (+5 / -9)
- Proline: +/ 18 % (-6)
- Hydroxyproline: +/ 14% (-2 / +2)
- Alanine: 11 % (-2 / +1)
- Lysine: 5 % (-1)
NB: Pour le collagène selon Ray PEAt, myprotein .com, Great lakes.
Si prise de glycine : 2 x 5 g, assimilation 20 % selon un post de Haidut.