Negative ions and health
-
What do you think about this?
Isn't "oxidative stress" in the bioenergetic world the same as not enough oxidation, not too much?
-
not really. not enough oxidation is reductive stress
-
@revenant said in Negative ions and health:
What do you think about this?
Incredible video. I had know idea they were studied for cancer.
-
@revenant said in Negative ions and health:
Isn't "oxidative stress" in the bioenergetic world the same as not enough oxidation, not too much?
Stress is useful under under well-regulated conditions. If stress induces stimulation, it is positive, if it is followed by a period of rest. It is repetitive stress, inducing a change in protein configuration/integrity and a lost in energy (hypothyroid), which is the problem. This will result in inflammation, dysfunction and then programmed cellular death.
Excerpt:
Water: swelling, tension, pain, fatigue, aging
Ray PEAT 2009
https://raypeat2.com/articles/articles/water.shtmlCells aren't osmometers, in the sense the textbooks say. They do control their water content, but no "membrane pumps" are needed. It's more accurate to think of the water of cells as being "dissolved in cells," somewhat the way water is contained in jello or boiled eggs. The cell controls its hydration by the processes that control its structure, its metabolism, and movements, because water is part of its deepest structures and essential functions. The cell's adjustments to changes of hydration and volume appear to be regulated by contractile proteins and energy metabolism (Minkoff and Damadian, 1976).
Any stress or energy deficit that disturbs cellular structure or function disturbs the interactions among water, proteins, and other components of the cell. Excitation causes a cell to take up extra water, not by osmosis resulting from an increase in the concentration of solutes in the cell, or because the membrane has become porous, but because the structural proteins of the cell have momentarily increased their affinity for water.
This increased affinity is similar to the process that causes a gel to swell in the presence of alkalinity, and it is related to the process called electro-osmosis, in which water moves toward a higher negative charge. Intense excitation or stress increases the cell's electrically negative charges, and causes it to become more alkaline and to swell. Swelling and alkalinity cause the cell to begin the synthesis of DNA, in preparation for cell division. Mitogens and carcinogens, including estrogen, cause cells to become alkaline and to swell, and substances that block the cell's alkalinization (such as the diuretics acetazolamide and amiloride) inhibit cell division. Prolonged alkaline stress alone can cause malignant transformation of kidney cells (Oberleithner, et al., 1991).
The general idea of "stress" is useful, because it includes processes such as fatigue, osmotic pressure changes, disturbed pH, and the enzyme changes that follow, producing substances such as lactic acid, nitric oxide, polyamines, estrogen, serotonin, and many more specific mediators. But paying attention to the physical factors involved in a stress reaction is important, if we are to see the organism integrally, rather than as a collection of "specific biological mechanisms," involving things like the pixie-powered "membrane pumps."
When a cell shrinks under hyperosmolar conditions, its metabolism becomes catabolic, breaking down proteins and glycogen, and sometimes producing lactic acid, which results in an alkaline shift, increasing the cell's affinity for water, and causing it to return to normal size. A slight degree of hyperosmolarity increases the cell's metabolic rate.
Swelling in hypo-osmolar conditions, i.e,, with an excess of water, is anabolic, leading to cellular proliferation, and inhibiting the breakdown of protein and glycogen. -
From RP:
When cells are stimulated, they adapt, with substance flowing into complexification until an approximate, appropriate equilibrium is reached. Stimulation is a need, and an opportunity, for adaptation and differentiation. If there is a need for adaptation, without the necessary substance and energy, the cell or organism will either deteriorate or withdraw.
Energy, structure, and carbon dioxide: A realistic view of the organism
Ray Peat
Discussion in 'Articles & Newsletters' started by mas, Mar 8, 2014.
https://raypeatforum.com/community/threads/energy-structure-and-carbon-dioxide-a-realistic-view-of-t.3344/#post-39530
