Blocking cortisol extends lifespan more than rapamycin, by improving mitochondrial function
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@haidut Now that you mention it, there are some pretty wild changes in Elon's appearance. At one point he seemed to be aging rapidly with very marked wrinkles, grey hair, and a very unhealthy looking hue. Few weeks later he looks like a vibrant 30 year old. Has he himself ever commented on what he's taking?
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@haidut
Even though I agree with everything you said, unfortunately we have no evidence of it from this study. As you may guess from my name, I know some things about fruitflies and their hormones. Basically, flies do not have a cortisol analogue, so in this case mifepristone acts as a progesterone antagonist. Flies change a lot their guts with reproduction to maximise egg production at the cost of their fitness/lifespan decrease. Basically, mifepristone blocks flies' progesterone (called juvenile hormone) and this prevents the remodelling of their intestine (which involves a reduction in mitochondrial efficiency). So blocking flies' progesterone or mTor has no additive effect as they both go towards the same direction reducing gut growth and turning flies into sterile.
Anyway, I hope this kind of studies will come soon in mice even though we know already the outcome ;). I hope that within a couple of years I will be able to start my own research group and I will get in touch with you! I'd love to think together new ways to test Peat 's principles or your compounds with my fruitflies! -
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@fruitfly Good reply. Thanks for sharing.
I was thinking I want to see this replicated with a series of mammals and then we'll see. As opposed to RU486 we actually have this data on rapamycin and it does increase lifespan significantly in all of those species.And calling rapamycin very dangerous is a stretch. The immune suppression is more towards excessive inflammatory cytokines.
Dare to think.
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@Mauritio what is the difference between the immunosuppressive effect of cortisol and that of rapamycin?
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@Epik this guy gives a great answer at 51:22
Rapamycin dampens excessive sterile inflammation that is often present unnecessarily in old age.
While cortisol has a strong short term anti-inflammatory effect as well, it is disastrous for the body in the long run.
Dare to think.
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This makes the case stronger that a carnivorous diet makes us age more, doesn't it?
Temporal thinking is the faculty that’s
engaged by an enriched environment, but it’s
wrong to call it “thinking,” because it’s simply
the way organisms exist... - Ray Peat Nov 2017 Newsletter -
@yerrag definitely. I think it has benefits because of endotoxin reduction and reduction of toxic chemicals.
But the mTOR activation and high amounts of methionine and cysteine are definitely an issue.
Large amounts of gelatin might protect to some degree. But the studies on rapamycin and methionine restriction are so obvious and many that I don't think theres a way around this.
It always leads back to a high carb diet.Dare to think.
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@Mauritio And not only that, but cortisol destroys the thymus gland and the thymus gland is where t-lymphocytes mature, and this has the effect of lowering immunity.
Temporal thinking is the faculty that’s
engaged by an enriched environment, but it’s
wrong to call it “thinking,” because it’s simply
the way organisms exist... - Ray Peat Nov 2017 Newsletter -
@yerrag
Yes, although this study shows rapamycin has thymus weight lowering effect in mice. Although there was clearly a dose dependant effect and the HEDs were like 15-60mg per day which is really high, so I'm not sure if there would be any such effect if you were to take just 1-5mg / week .
So the weekly dose of this study was about 30-100 times higher than what most humans take.
