Peaty uncoupler vs. Ozempic who wins ? New study.
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Very interesting study, that compares a bunch of weight loss drugs in terms in diabetic mice.
Why this is so relevant is because they included a relatively new uncoupler, called BAM15, which is basically a safe version of DNP.
BAM15 has been used in other studies with remarkable results.
So now they compared it against calorie restriction (60%) and Ozempic a.k.a. semaglutide.Findings:
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BAM15 (highest dose) decreased body weight by 30% , just as much as restricting calories by 60%. BAM didn't cause a reduction in food intake.
Let that sink in. You don't need to starve yourselves and get ozempic face.
Ozempic only caused a 12% body weight reduction.
Body weight:
Mice fed BAM15 had the highest percentage of muscle of all treatment groups.
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Glucose tolerance:
Again: highest BAM15 dose was at least equally as effective as semaglutide in restoring glucose tolerance. Even though semaglutide is marketed as a diabetes treatment. -
When it comes to liver health Bam was more effective than semaglutide . It lowered liver triglycerides way more then semaglutide and it also lowered overall liver weight more.
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BAM15 increases oxygen uptake by about 20% weight increasing movement, indicating Uncoupling.
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The calorie restriction group actually didn't loose much more muscle than the other treatment groups, which is surprising.
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They also looked at niclosamide (NEN), which was pretty useless. Niclosamide doesn't seem to work well in diabetic individuals, but otherwise it's a great drug. Talked about it here: https://bioenergetic.forum/topic/3563/niclosamide-reduces-serotonin-and-glutamate?_=1745666192303
STUDY:
https://pmc.ncbi.nlm.nih.gov/articles/PMC10908303/#S13 -
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BAM15 is only available at this website AFAIK
https://swisschems.is/product/bam-15-15mg-capsule-60-capsules/Unfortunately they dont ship to Germany, so I can't try it. But if someone from the US would be willing to split theirs with me, I'd be very happy:)
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio It's available at much cheaper prices and much higher quantities via reputable peptide vendors.
Seems interesting. Would love to try some if I see some lab tested product available.
However the doses were UNREASOABLE AND DANGEROUS
The diet was composed of 0.1% and 0.2% BAM 15. For example; The average food daily intake of the 0.1% group was roughly 10 grams a day on average
Therefore, they were intaking 0.01g of BAM 15 a day.
The body weight of this group before the treatment was around 30 grams and after the treatment it was around 40 grams. We do not have access to average bodyweight - so we do not have the same units as average food intake.
Let’s assume their average body weight was half way between the starting and end bodyweight; 35 grams.
35 grams is 0.035kg
This means they were consuming 2.857 grams of Bam 15 per kg of bodyweight. (0.01/0.035)
In milligrams this is 2857 milligrams per kg of body weighh
The HED dose would be only 228.57mg / kg a day.
For a 80kg man, this is 18,285 milligrams a day or 18.25grams a day
Luckily the semaglutide dosage was much more simple to calculate. It was a dose of 0.3mg per kg twice per week. The HED is 0.024mg per kg twice per week.
This means that for a 80kg man this is 1.92mg of semaglutide twice per week. This is nearly double the maximum dose approved by the FDA which is 2.25mg a week.
So you are comparing 3.84mg of Ozempic a week to 18 grams of BAM 15 a day lol. Not a fair comparison but it’s the fault of the authors
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@alfredoolivas My main concern is that BAM 15 has a potentially toxic structure:
It contains 2 fluoride atoms, and this often causes issues with drugs. @haidut does not reccomend BAM 15 for these reasons.
Toxicity was not seen in animal studies... but they may be consuming much lower doses spread out throughout the day compared to doses seen in supplements.
Also lets stop with the dogmatic "Ozempic bad" opinion
The semaglutide had similar / slightly higher fat free mass % than the BAM 15 groups
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10 grams of BAM 15 costs 300 dollars from one of the main chinese peptide suppliers at the moment (Sigma Audley)
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She combined them and this happened (reportedly she has no regrets) lol
