Peaty uncoupler vs. Ozempic who wins ? New study.
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BAM down regulated SCD1 by almost 900-fold ! SCD1 concerts saturated fats into unsaturated fats and is implicated in many chronic diseases.
"...severe downregulation of sterol regulatory element‐binding transcription factor 1 (Srebf1 ; 490‐fold downregulated), carbohydrate‐responsive element‐binding protein (Mlxlpl ; 99‐fold downregulated), fatty acid synthase (Fasn ; 89‐fold downregulated), stearoyl‐CoA desaturase (Scd1 ; 898‐fold downregulated), adipose triglyceride lipase (Pnpla2 ; undetected in BAM15), and peroxisome proliferator‐activated receptor gamma (Pparg ; undetected in BAM15)”
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Could be worse.
"In this study, the aged mice increased their muscle mass by an average of 8 percent, their strength by 40 percent, while they lost more than 20 percent of their fat.”
https://www.sciencedaily.com/releases/2022/04/220407101053.htmBAM15 increases interesting enzymes for mitochondrial functioning.
ATP Synthase for example. Which leads to more ATP beeing produced.
Citrate synthase was increased about 3-fold.
Wikipedia:
“Citrate synthase is commonly used as a quantitative enzyme marker for the presence of intact mitochondria. Maximal activity of citrate synthase indicates the mitochondrial content of skeletal muscle.[6] The maximal activity can be increased by endurance training or high-intensity interval training,[6] but maximal activity is further increased with high-intensity interval training.[7]”
→ exercise mimetic?Therefore muscle mitochondria content was more than doubled in BAM15 treated mice!
The amount of fast twitch fibers doubled!
Could be helpful for weightlifters, sprinters, etc.
"We observed a significant increase in the fast-twitch muscle myosin heavy chain type 2 (MyHCII) but not the slow-twitch type I (MyHCI) protein expression with BAM15 compared with CTRL (Figure 2F). "Big increase in PINK1 . Important for parkinsons prevention
https://onlinelibrary.wiley.com/doi/10.1002/jcsm.12982 -
BAM15 for cancer
“In vivo investigations revealed that BAM15 effectively suppressed AML progression and prolonged the survival time of mice.”
https://www.sciencedirect.com/science/article/abs/pii/S0006295222000429
BAM for breast cancer:
"Collectively, these data indicate that mitochondrial uncoupling may be an effective strategy to limit proliferation of aggressive forms of breast cancer. "breast cancer:
https://cancerandmetabolism.biomedcentral.com/articles/10.1186/s40170-021-00274-5
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The question wrt BAM15's 11.1% fluorine content isn't "has the compound been found safe" but does the fluorine ever dissociate in-vivo from the BAM15 molecule. If it does that's a no-no already at 10mg daily and even if "found safe". I reckon since the fluorine is incorporated in BAM15'S aromatic ring it probably is very resistant and unlikely to dissociate.
So what are the commonly applied and reported human doses of BAM15?
@Mauritio said in Peaty uncoupler vs. Ozempic who wins ? New study.:
Pparg ; undetected in BAM15
Meaning totally enabled fatty acid oxidation and lipolysis and inhibited lipogenesis by PPARg.
Does DNP exhibit a similar focus on fat burning? What's the comparative advantage to and issue with DNP as long as its dose is safely kept reasonable? -
Ah, the BAM15 is more selective than DNP and therefore safer with regard to off-target side effects:
- "Recently, we reported the identification of a novel mitochondrial uncoupler, BAM15 (5), which selectively depolarizes the inner mitochondrial membrane but not the plasma membrane.68"
- "[...] the toxicity issues associated with DNP are due to a narrow therapeutic window, which may result from unwanted depolarization of non-mitochondrial membranes such as the plasma membrane.53–56"
https://pmc.ncbi.nlm.nih.gov/articles/PMC8224984/
That's a comparative merit.
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@Mauritio said in Peaty uncoupler vs. Ozempic who wins ? New study.:
The dosages are very high. But that proves their safety. I you critique the potential side effects based on it's structure, you should acknowledge this study as proof of safety, because of the high dosage.
@Mauritio How do you know a 0.1% and a 0.2% BAM 15 diet was safe for mice?
They only checked metabolic markers such as glucose & insulin, cholesterol, triglycerides, fat mass and muscle mass.
You cannot assess toxicities from these markers. Did they check hepactic enzymes, kidney function & did they do an autopsy? These are examples of tests they can do to check the toxicity of a drug, amongst many others.
So you cannot say it was safe from this study alone.
Via your defintion of toxicity. DNP is also safe. DNP given at mice at a dose of 89mg per kg (HED 7.12mg/kg, 569.6mg a day for a 80kg man), lowered triglycerides, lowered liver weight, lowered ALT... so it's not toxic according to your criteria, when in reality it is.
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He is cutting calories and doing low carb
"I will say that during this I am also dieting very hard, high protein a decent amount of fats, and very low carb. I am also doing about an hour or so of cardio per day. As I mentioned above this is going to be a very intense cut so I do not recommend doing this. Not much else to report on but so far so good."
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@CrumblingCookie I think those two things come down to the same conclusion.
Because if the fluoride atoms disassociated , should not that show up relatively quickly via systemic side effects, as in liver and kidney damage ? If not, how else do you suppose the damage would show up.In these 2 studies they looked at liver and kidney markers and found no significant difference.
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@Mauritio said:
I think those two things come down to the same conclusion.
Because if the fluoride atoms disassociated , should not that show up relatively quickly via systemic side effects, as in liver and kidney damage ?Not necessarily as I think of fluorine/fluoride harboring quite some insidious effects on endrocrine and exocrine glands. If there was huge fluorine unloading we could expect kidney damage. E.g. if all 22mg fluorine of 200mg BAM15 dissociated.
But if it's only 5% or 10% dissociation and therefore 1.1 or 2.2mg fluorine/fluoride per day it won't be obvious but very obfuscated in a range of unspecificity. Would then require larger daily amounts of iodide and support of renal excretion to counteract.
For comparison, amiodarone also has its two halogens (iodine, 37% w/w) attached to its aromatic ring so just as with BAM15 we would expect little dissocation. It's been shown however to yield c. 10% dissociation of iodine and any dose above the very-low-dose 100mg/d is therefore an established possible cause for blood--testis barrier disruption and inflammatory degradation of the interstitial testicular tissue in humans.
Well if anyone's worried about F in BAM15 then 2-3mg of daily KI wouldn't be the worst to stack with it or in general. -
If anybody from Europe is interested in a group buy of BAM15 from sigma audley, hit me up.
We're gonna buy 10g for 300$ and divide through 3 people.
(1 spot left)
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio how do you get an account on sigma Aldrich? Thanks
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@Mauritio it’s a good vendor, they ship to a warehouse in Germany which gets reshipped to your address in Europe - so when the package goes through customs, it hasn’t got your name on it and there is virtually 0 risk of consequences of your package being detained. Also it’s very rare for these shipments to get seized from these vendors.
Best of luck with your experiment
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@BeamsOfEnergy no it's sigma AUDLEY . A Chinese steroid selling company.
Look at @alfredoolivas response above .
They have a decent reputation, but of course its not Amazon customer service, so stuff goes wrong.
Here's a 400+ pages long thread on them. With countless successful orders , but also some delays, stuff missing etc.
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@alfredoolivas thanks. Yes and don't they also have a warehouse in Germany directly ?
Not sure if they store BAM 15 there though .They seem as legit as it gets ,at least for company doing what they do lol.
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio no warehouse in the EU as of now, only USA.
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@Mauritio
I'm interested. I live in the US but all my family is in The Netherlands. You could send it there and they can send it to me. -
@happyhanneke nice. Just send me message and we'll set it up.
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"This study indicates that BAM15 inhibits atherosclerosis through a multi-molecular mechanism, and we propose it as a novel anti-atherosclerotic drug."
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Science is slowly getting more peaty.
Combination of a thyroid receptor b agonist with BAM15 for fatty liver, showed superior results than each on their own. -
@Mauritio post ur before and after too
