Vitamin E Forms in Alzheimer’s Disease: A Review of Controversial and Clinical Experiences
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Vitamin E Forms in Alzheimer’s Disease: A Review of Controversial and Clinical Experiences
This study examined the alpha-tocopherol supplement instead of gamma–tocopherol. Gamma-tocopherol has been found to be more effective in scavenging free radicals and nitrogen oxygen species that cause inflammation; both of these are components of neurodegenerative disorders. Secondly, the use of alpha-tocopherol supplements significantly reduces serum gamma-tocopherol, and this may have important biological effects. Therefore, any potential health benefits of alpha–tocopherol supplements may be offset by deleterious changes in the bioavailability of other forms of tocopherols and tocotrienols. This might account for the null effects of alpha tocopherol supplementation in Mild Cognitive Impairment and Alzheimer's Disease.
Mixed tocopherols are best?
You can catch more flies with honey than vinegar. 👀
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If this were true, then the FDA has single-handedly made made it easier for people to develop Alzheimer's by making it impossible, in the 1930s, for Kodak's subsidiary, Eastman Chemical, to market a mixed tocopherol product that it had made from soya oil. Instead, the FDA made alpha-tocopherol acetate its gold standard. For which now many supplement makers would offer the acetate form as their Vitamin E offering.
This is consistent with the hidden health-robbing and chronic disease-favoring mandate of the FDA, in encouraging the use of second rate and more expensive non-solutions but band-aids to the systematic wrecking of the capability of the human organism to heal itself. Cancer, heart disease, diabetes, are the direct results of a century+ effort to keep humans from developing to its metabolically optimal capability. Together with impoverishing human society with the use of mickey mouse money, thru the Federal Reserve, and in conjunction with pitting humans against each other, using the CIA and M16 and the Mossad, the FDA carries out the parasitic mandate effectively.
Banning carbogen, pushing PUFAs, diluting the healing and health promoting properties of Vitamin E, promoting vaccines and the use of persorptive toxins to introduce insults internally to create continual virtual battlegrounds within the body - to name a few - point to a continuing effort to cripple humanity into slavish dependencies on a ruling master class.
Every little cut adds up till humanity dies or falls by a thousand cuts.
Temporal thinking is the faculty that’s
engaged by an enriched environment, but it’s
wrong to call it “thinking,” because it’s simply
the way organisms exist... - Ray Peat Nov 2017 Newsletter -
@DavidPS said in Vitamin E Forms in Alzheimer’s Disease: A Review of Controversial and Clinical Experiences:
Mixed tocopherols are best?
Peatbot: Yes, mixed tocopherols are generally considered better than just d-alpha tocopherol alone. Research has shown that mixed tocopherol preparations, which include alpha, gamma, and delta tocopherols, provide superior protection and efficacy compared to alpha-tocopherol alone. For example, a study by Chen et al. (2002) found that a mixed tocopherol preparation was much superior to alpha-tocopherol in terms of myocyte protection against hypoxia-reoxygenation injury. Additionally, the absence of gamma- and delta-tocopherols in commercial tocopherol preparations may contribute to their lack of efficacy in clinical trials. Therefore, a mixed tocopherol supplement is recommended for better overall benefits.
All you need is love. But a little chocolate now and then doesn't hurt.
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@yerrag said in Vitamin E Forms in Alzheimer’s Disease: A Review of Controversial and Clinical Experiences:
Banning carbogen, pushing PUFAs, diluting the healing and health promoting properties of Vitamin E, promoting vaccines and the use of persorptive toxins to introduce insults internally to create continual virtual battlegrounds within. the body - to name a few - point to a continuing effort to cripple humanity into slavish dependencies on a ruling master class.
Every little cut adds up till humanity dies or falls by a thousand cuts.
Lingchi (aka death by a thousand cuts) was an especially painful form of torture. During the covid debacle, the following quote made sense to me.
The gap between healthspan and lifespan seems to be widening. I am wondering if the word 'healthspan' had to be invented to describe the consequences of our misdirected lifestyles. 'Turbo cancer' is yet another label that needed to be created to normalize the sudden consequences of our misdirected government recommendations.
You can catch more flies with honey than vinegar. 👀
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@otto - Thanks. Dr. Peat was very insightful.
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#notatocovitadvertisement
#letsseewhattravissays
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I have a hard time understanding what it means to be nucelophilic and how it differs from electrophilic, and why and how it matters.
Alpha-tocopherol is nucleophilic and gamma-tocopherol is electrophilic.
Do you have an explanation that isn't like one of those things that can never be understood, like 'parasympathetic and "sympathetic?'
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@yerrag - Unfortunately, I do not have a strong chemistry background and I would be of little help.
https://psiberg.com/electrophiles-vs-nucleophiles/ -
@yerrag said in Vitamin E Forms in Alzheimer’s Disease: A Review of Controversial and Clinical Experiences:
If this were true, then the FDA has single-handedly made made it easier for people to develop Alzheimer's by making it impossible, in the 1930s, for Kodak's subsidiary, Eastman Chemical, to market a mixed tocopherol product that it had made from soya oil. Instead, the FDA made alpha-tocopherol acetate its gold standard. For which now many supplement makers would offer the acetate form as their Vitamin E offering.
This is consistent with the hidden health-robbing and chronic disease-favoring mandate of the FDA, in encouraging the use of second rate and more expensive non-solutions but band-aids to the systematic wrecking of the capability of the human organism to heal itself. Cancer, heart disease, diabetes, are the direct results of a century+ effort to keep humans from developing to its metabolically optimal capability. Together with impoverishing human society with the use of mickey mouse money, thru the Federal Reserve, and in conjunction with pitting humans against each other, using the CIA and M16 and the Mossad, the FDA carries out the parasitic mandate effectively.
Banning carbogen, pushing PUFAs, diluting the healing and health promoting properties of Vitamin E, promoting vaccines and the use of persorptive toxins to introduce insults internally to create continual virtual battlegrounds within the body - to name a few - point to a continuing effort to cripple humanity into slavish dependencies on a ruling master class.
Every little cut adds up till humanity dies or falls by a thousand cuts.
Preach it, Brother! Right on!!
You might find this Tucker Carlson show of great interest. Tucker is red pilling the entire population! This video is less than a week old.
Even though the MD (who quit her job as surgeon) is suffering under some delusions, like omega 3's GOOD, she is ethical and has stepped up to the plate, along with her brother. I'm amazed that Youtube is allowing this video to be shown. I pray for her safety.
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Has anyone looked into Dr Barrie Tan's work on tocotrienols? He claims, in a very summarised way, that they are better than a-tocopherol.
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I've looked into him. He is a fraud. He is another pharma plant to draw us away from real vitamin E. For those who don't know rhe real story though, he appears legit. I couldn't convince a cousin to stay away from his bull.
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@yerrag wow! Thank you, I’m so glad I asked. Do you have any sources about this by any chance or any other info about him please?
I always wondered how Ray could’ve supposedly missed this type of “info” that only Barry Tan was able to have “discovered” etc. -
Please do a search on this on RPF. In there, I exposed his website which is said to contain his references and there was no article nor study supporting his claim.
Interestingly, his product is sold in Amazon Canada while brands such as Unique-E, which contain mixed natural tocopherols, are not available. The rest of the vitamin E offerings at best are made unhealthful by the vitamin E being mixed in a base of soya oil or some PUFA. This is because Canadian customs loves Canadians less and love the filthy medical establishment more.
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@yerrag will do, thank you
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I think I got an answer after thinking and sleeping and thinking about this for a long, long time. I could not put the difference between the alpha isomer and the gamma isomer in a context that is practical. Saying alpha is nucleophilic and gamma is electrophilic does not make me know which really to take. So I end up taking one over the other or both of them, just so I am safely protected whatever that means. But that just means I'm stumbling in the dark and no expert can ever give me an explanation I can really use.
Then it hit me. And I had to check with my Delphi Ray Peats AI to see if my 'more practical' explanation makes more sense. And he agreed with me.
So here it is. Boiled down and extracted of its essence, alpha-tocopherol based tocopherols are more useful when taken when you are eating out and you know you will be eating an unavoidable amount of PUFAs which always accompanied foods served, especially in popular restos where taste is paramount and chefs are paid for flavor and not for health (but of course as who goes to healthful restos but vegans and is veganism even that healthful but we can agree the flavor is zero). So, the bottom line is use it when you eat where you know you'll be eating a lot of PUFAs. Hopefully that won't be the case often, and doesn't give you an excuse to eat out too often and thinking the alpha tocopherol-heavy vitamin E is an amulet to ward off the lipid peroxidation devil.
In short, it is taken to keep the lipid peroxidation from getting atarted.
OTOH, gamma-tocopherol is meant to be taken for keeping the oxidized cholesterol in the plaque lining our blood vessels from undergoing further oxidation. Oxidized cholesterol, as Ray Peat clarified with me, is not all fully oxidized. It continues to oxidize as plaque. I think it should be called continually oxidizing cholesterol to be more accurate and to be less misleading. Gamma to opherol then is useful for those of us who have a past history of taking PUFAs and which have come to be part of our plaque as continually oxidizing cholesterol.
I've stopped taking PUFAs at home for 9 years already, but I have a PUFA past, so I would be big on taking gamma-tocopherol-heavy mixed tocopherols for my vitamin E supplementation.
I suspect the lipid peroxidation it carries out requires my body to use albumin (as well as other antioxidants such as uric acid) as an antioxidant to counter the oxidative stress caused by lipid peroxidation. As albumin gets oxidized and gets excreted thru urine (characterized by urine foam or froth), it depletes my serum albumin and this lowers the blood volume (as albumin attracts sodium and sodium attracts more water) and this is a main cause of my high blood pressure.
Anyway, to keep this topic from devolving, suffice it to remember gamma-tocopherol is needed for lipid peroxidation already begun and continuing in the plaque of our blood vessels.
But when I eat out, or when I am on food trips on travels, I'll bring a d-alpha tocopherol-heavy vitamin E with me.
