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    Random, interesting studies

    Literature Review
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    • MauritioM
      Mauritio
      last edited by Mauritio

      Coca leaves

      • traditionally been used for altitude sickness (MoA= increase in CO2?),
        Increasing stamina and reducing hunger and fatigue

      • Cocaine is just one of the many bioactive molecules. It contains 14 alkaloids in total .
        They probably have synergistic effects.

      The biological activity of the following alkaloids has been reported in the literature: cocaine, cinnamoylcocaine, benzoylecgonine, methylecgonine, pseudotropine, benzoyltropine, tropacocaine, alpha- and beta-truxilline, hygrine, cuscohygrine and nicotine.

      https://pubmed.ncbi.nlm.nih.gov/6379304/

      • Ray said that the issue with cocaine is that increases your metabolism so much that you quickly develope vitamin deficiencies. This study found that chewing coca leaves increases the metabolisms of subjects by up 66%. There was one guy in the study for who it reduced it metabolism by about 20% and it was also the guy with the lowest body temp. Coca leaves actually decreased his temp from 36.3 to 36°C. So it seems like it made him hypoglycemic,maybe he didn't eat beforehand ?
        For another guy it increased his temps to 37.6 .

      Interesting read:
      http://www.scielo.org.pe/scielo.php?pid=S1726-46341944000400003&script=sci_arttext&tlng=en


      Man cured his arthritis and impotence with coca.
      1000023865.jpg

      https://pubmed.ncbi.nlm.nih.gov/6113306/

      Dare to think.

      My X:
      x.com/Metabolicmonstr

      1 Reply Last reply Reply Quote 2
      • MauritioM
        Mauritio
        last edited by Mauritio

        Aronia berry

        A small amount of the extract increased the body temperature of women by over a degree.
        https://pmc.ncbi.nlm.nih.gov/articles/PMC3843504/#Sec2

        Anthocyanins from Aronia (cyanidin
        291 3-arabinoside, cyanidin 3-galactoside, cyanidin 3-xyloside and cyanidin 3-glucoside) increased the effects of the anti aging protein klotho.
        It increased several health markers of the brain.
        They also increased antioxidants and monoanines of which dopamine was increased the strongest in the brain.
        They also drastically down regulated COX-2 and inflammatory cytokines.
        https://pubmed.ncbi.nlm.nih.gov/28657734/

        Aronia polyphenols drastically increased PGC1a in Brown adipose tissue (new mitochondria) and slightly increased UCP1.
        https://pmc.ncbi.nlm.nih.gov/articles/PMC7339576

        Here we got an anti-inflammatory effect of aronia. But what's more interesting is that they used histamine and serotonin to induce the inflammation, including the (paw) edema. Notably, the concentration needed to induce inflammation was 50 times lower for serotonin than for histmine. And histamine is a known inflammation induced, yet you rarely hear the same thing about serotonin, although it seems to be a lot more harmful in that regard.

        "Inflammation of rat hind paw was induced either by 0.5% solution of histamine or by 0.01% solution of serotonin."
        https://pubmed.ncbi.nlm.nih.gov/7892768/

        Dare to think.

        My X:
        x.com/Metabolicmonstr

        sunsunsunS 1 Reply Last reply Reply Quote 0
        • MauritioM
          Mauritio
          last edited by

          Dopamine and noradrenaline drastically reduced in part of the brain. Serotonin not.

          In PD, the levels of dopamine and noradrenaline were greatly reduced by 93 and 81%, respectively.
          https://pubmed.ncbi.nlm.nih.gov/27741357/

          Dare to think.

          My X:
          x.com/Metabolicmonstr

          1 Reply Last reply Reply Quote 0
          • MauritioM
            Mauritio
            last edited by

            Cacao polyphenols have anti-viral effects
            https://www.sciencedirect.com/science/article/pii/S2405844023030670
            https://pmc.ncbi.nlm.nih.gov/articles/PMC8141698/

            Dare to think.

            My X:
            x.com/Metabolicmonstr

            1 Reply Last reply Reply Quote 0
            • sunsunsunS
              sunsunsun @Mauritio
              last edited by

              @Mauritio Aronia products are being pushed by marketers so much lol

              1 Reply Last reply Reply Quote 0
              • MauritioM
                Mauritio
                last edited by Mauritio

                2.0 g of meldonium daily for 90 days improved sperm health increased testosterone by about 70% in boars.

                https://www.wellesu.com/10.1016/j.anireprosci.2012.11.007

                "Meldonium treatment in both models restored mitochondrial bioenergetics. The results show that meldonium treatment prevents the development of RV and LV systolic dysfunction by enhancing mitochondrial function in experimental models of ventricular dysfunction that resembles cardiovascular complications in COVID-19 patients."
                https://pmc.ncbi.nlm.nih.gov/articles/PMC8744985/

                Reducing FAO Enhances Antiviral Signals
                https://pubmed.ncbi.nlm.nih.gov/39142373/

                Dare to think.

                My X:
                x.com/Metabolicmonstr

                H 1 Reply Last reply Reply Quote 1
                • H
                  heyman @Mauritio
                  last edited by

                  @Mauritio Wow nice, Ive been taking mildronate for close to 3 months now. Love it so far, great energy and a sort of calmness. Been loosing weight too.

                  these soviet medicines I sure do like

                  MauritioM 1 Reply Last reply Reply Quote 0
                  • H
                    heyman @Mauritio
                    last edited by

                    @Mauritio What bible do you consume? My suggestion is to read the original text and not some sorry ass translation.

                    The soul is the metabolism, the spirit is the mind.

                    1 Reply Last reply Reply Quote 0
                    • MauritioM
                      Mauritio @heyman
                      last edited by

                      @heyman how much are you taking?

                      Dare to think.

                      My X:
                      x.com/Metabolicmonstr

                      H 1 Reply Last reply Reply Quote 0
                      • H
                        heyman @Mauritio
                        last edited by

                        @Mauritio 0,5g to 1g a day

                        really like it, I get this calm, nice energy from it.

                        MauritioM 1 Reply Last reply Reply Quote 0
                        • MauritioM
                          Mauritio @heyman
                          last edited by

                          @heyman interesting. I've been taking it for two days . First became really hypoglycemic .

                          Dare to think.

                          My X:
                          x.com/Metabolicmonstr

                          H 1 Reply Last reply Reply Quote 0
                          • H
                            heyman @Mauritio
                            last edited by

                            @Mauritio yeah carbs is important

                            I try to have some coca cola, sprite on hand

                            burp

                            1 Reply Last reply Reply Quote 0
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