The Impact of Alpha-Ketoglutarate (AKG) on Skeletal Muscle Health and Exercise Performance
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Impact of Alpha-Ketoglutarate on Skeletal Muscle Health and Exercise Performance: A Narrative Review (2024)
Alpha-ketoglutarate (AKG) is a pivotal metabolic intermediate within the Krebs cycle and it plays a vital role in cellular energy production and nitrogen metabolism. Table 1 is summary of AKG's various roles.
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@DavidPS said in The Impact of Alpha-Ketoglutarate (AKG) on Skeletal Muscle Health and Exercise Performance:
Alpha-ketoglutarate
Did you happen to see if L-Arginine a-Ketoglutarate is just as beneficial?
I should rephrase, in other words do studies delineate on the amino acid conjugated? -
@bio3nergetic - Arginine α-ketoglutarate (AAKG) containing supplements have been associated with adverse effects requiring hospital admission.
Adverse effects associated with arginine
α-ketoglutarate containing supplements (2009)Risk assessment of "other substances"
– L-arginine and arginine alpha-ketoglutarate (2016)Most the recent work has been performed using calcium α-ketoglutarate (Ca-AKG) which is more expensive but not life-threatening.
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Thanks @DavidPS I am some how not surprised! Arginine anything is a major risk.
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Interesting. There's some good studies on AKG longevity and metabolism .
I think it's worth a try, have you tried it ? @davidpsDare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio - Yes I have tried AKG as a supplement and I still use it. I have not noticed any specfic muscle and exercise performance benefits. I am trying to stay healthy. AKG is formed in gut and I am not willing to assume that my gut microbiome is not the weakest link in my health.
Alpha-Ketoglutarate, the Bacteriome, Protein Metabolism, and Longevity (2026)AKG is part of the Krebs cycle.
Wiki states that the body has a way to handle excess. See:
https://en.wikipedia.org/wiki/Α-Ketoglutaric_acidHere is another general reference from 2016.
Alpha-Ketoglutarate: Physiological Functions and Applications
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@DavidPS Thanks
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α-Ketoglutarate Is a Circulatory Exercise Factor That Promotes Learning and Memory Recall and Has Antidepressant Properties
- Increase in PGC-1a and BDNF
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α-Ketoglutarate promotes amino acid depletion and suppresses B-cell lymphoma growth and development
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio - Thanks for the link. I started taking AKG in 2020 after I read that it restores hair color in some people. It did not work for me but it is still on my short list of supplements.
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@DavidPS how much are you taking everyday ?
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio - I take a gram which I split into 2 doses.
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@DavidPS Ok thanks. Have you ever posted your daily supplement stack ? Would be interesting to read.
Dare to think.
My X:
x.com/Metabolicmonstr -
@Mauritio - I am a whole foods type of person. I encourage others to get their nutrients from food.
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